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1,2 - Propanediol, dinitrate

RTECS #: TY6300000

CAS #: 6423-43-4


UPDATE: May 2009 MW: 166.11 MF: C3H6N2O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2 - Propylene glycol dinitrate
  2. PGDN
  3. Propylene dinitrate
  1. Propylene glycol 1,2 - dinitrate
  2. Propylene glycol dinitrate
  3. Propylene glycol dinitrate (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg mild TXAPA9 22,128,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 200 ppb/6 hour Behavioral: Headache TXAPA9 30,377,1974
inhalation
human
lowest published toxic concentration: 1,500 ppb/5 minute Eye: Conjunctiva irritation TXAPA9 30,377,1974
intraperitoneal
guinea pig
lethal dose (50 percent kill): 402 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 34,526,1973
intraperitoneal
mouse
lethal dose (50 percent kill): 1,047 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia

Vascular: BP lowering not characterized in autonomic section
AIHAAP 34,526,1973
intraperitoneal
rat
lethal dose (50 percent kill): 479 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia

Vascular: BP lowering not characterized in autonomic section
AIHAAP 34,526,1973
intravenous
monkey
lowest published lethal dose: 410 mg/kg Eye: Ptosis

Behavioral: Ataxia

Gastrointestinal: Nausea or vomiting
TXAPA9 22,128,1972
oral
mouse
lethal dose (50 percent kill): 1,525 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: EKG changes not diagnostic of above

Blood: Methemoglobinemia- Carboxhemoglobinemia
STGNBT -,94,1999
oral
rat
lethal dose (50 percent kill): 250 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia

Vascular: BP lowering not characterized in autonomic section
AIHAAP 34,526,1973
subcutaneous
cat
lowest published lethal dose: 200 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia
TXAPA9 15,175,1969
subcutaneous
mouse
lethal dose (50 percent kill): 1,208 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia
TXAPA9 15,175,1969
subcutaneous
rat
lethal dose (50 percent kill): 463 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia
TXAPA9 15,175,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 236 mg/m3/24 hour/90 day- continuous Blood: Pigmented or nucleated red blood cells

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TXAPA9 22,128,1972
inhalation
guinea pig
lowest published toxic concentration: 236 mg/m3/24 hour/90 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases TXAPA9 22,128,1972
inhalation
monkey
lowest published toxic concentration: 236 mg/m3/24 hour/90 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 22,128,1972
inhalation
rat
lowest published toxic concentration: 236 mg/m3/24 hour/90 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TXAPA9 22,128,1972
skin
rabbit
lowest published toxic dose: 73 gm/kg/3 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIHAAP 34,526,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 ppm (0.34 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.34 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 0.02 ppm (0.2 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.02 ppm (0.2 mg/m3), short term exposure limit 0.06 ppm, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 ppm (0.3 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.34 mg/m3 (0.05 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 0.05 ppm (0.3 mg/m3), skin, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.3 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 ppm (0.34 mg/m3), skin, JAN2002
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 ppm (0.7 mg/m3);
short term exposure limit 0.3 ppm (2 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.35 mg/m3),KZG- week 0.05 ppm (0.35 mg/m3), Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYLENE GLYCOL DINITRATE-air 10 hour time-weighted average 0.05 ppm (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Human Data
   Primary Irritant

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