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Phosphorodithioic acid, S,S' - methylene O,O,O',O' - tetraethyl ester

RTECS #: TE4550000

CAS #: 563-12-2


UPDATE: May 2009 MW: 384.49 MF: C9H22O4P2S4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Bis (S - (diethoxyphosphinothioyl) mercapto) methane
  2. Diethion
  3. ENT 24,105
  4. Embathion
  5. Ethanox
  6. Ethiol 100
  7. Ethion
  8. Ethion (ACGIH)
  9. Ethodan
  10. Ethopaz
  11. Ethyl methylene phosphorodithioate
  12. FMC - 1240
  13. Fosfatox E
  14. Fosfono 50
  15. Hylemox
  16. KWIT
  17. Methyleen - S,S' - bis (O,O - diethyl - dithiofosfaat) (Dutch)
  1. Methylene - S,S' - bis (O,O - diaethyl - dithiophosphat) (German)
  2. NIA 1240
  3. Niagara 1240
  4. Nialate
  5. O,O,O',O' - Tetraaethyl - bis (dithiophosphat) (German)
  6. O,O,O',O' - Tetraethyl S,S' - methylene di (phosphorodithioate)
  7. O,O,O',O' - Tetraethyl S,S' - methylenebisphosphordithioate
  8. O,O,O',O' - Tetraethyl - S,S' - methylenebisphosphorodithioate
  9. Phosphorodithioic acid, O,O - diethyl ester, S,S - diester with methanedithiol
  10. Phosphotox E
  11. RP 8167
  12. Rhodocide
  13. Rodocid
  14. S,S' - Methylen - bis (O,O - diaethyl - dithiophosphat) (German)
  15. S,S' - Methylene O,O,O',O' - tetraethyl phosphorodithioate
  16. Tetraethyl S,S' - methylene bis (phosphorothiolothionate)
  17. Vegfru fosmite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 864 mg/m3 N/R FMCHA2 -,C128,1991
intraperitoneal
mouse
lethal dose (50 percent kill): 35 mg/kg N/R PSEBAA 129,699,1968
intraperitoneal
rat
lethal dose (50 percent kill): 26 mg/kg N/R PSEBAA 129,699,1968
oral
wild bird
lethal dose (50 percent kill): 45 mg/kg N/R TXAPA9 21,315,1972
oral
guinea pig
lethal dose (50 percent kill): 40 mg/kg N/R 85DPAN -,-,1971/1976
oral
human
lowest published toxic dose: 100 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 22,286,1972
oral
infant
lowest published toxic dose: 15,700 g/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature increase
TXMDAX 63,71,1967
oral
mouse
lethal dose (50 percent kill): 40 mg/kg N/R 85DPAN -,-,1971/1976
oral
rat
lethal dose (50 percent kill): 13 mg/kg N/R PHJOAV 185,361,1960
skin
guinea pig
lethal dose (50 percent kill): 915 mg/kg N/R 85DPAN -,-,1971/1976
skin
rat
lethal dose (50 percent kill): 62 mg/kg N/R TXAPA9 14,515,1969
unreported route
rat
lethal dose (50 percent kill): 55 mg/kg N/R 30ZDA9 -,367,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 675 mg/kg/90 day- continuous Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 8,173,1988
oral
dog
lowest published toxic dose: 182 mg/kg/1 year- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
TOXID9 8,173,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (inhalable, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,117,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.4 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg/m3 (vapor, aerosol), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.4 mg/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 0.4 mg/m3, Skin, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 0.4 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.4 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.4 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.4 mg/m3, skin, JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 0.4 mg/m3, Skin, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHION-air 10 hour time-weighted average 0.4 mg/m3 (Sk) NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84542;
Number of Industries 1;
Total Number of Facilities 12;
Number of Occupations 1;
Total Number of Employees Exposed 72


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108024)
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
Used as an insecticide and acaricide
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London, SE1 7JN, UK) V.131- 1933-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXMDAX Texas Medicine. (Texas Medical Assoc., 1801 N. Lamar Blvd., Austin, TX 78701) V.60- 1964-

Used as an insecticide and acaricide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data

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