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2 - Pentanone, 4 - hydroxy - 4 - methyl -

RTECS #: SA9100000

CAS #: 123-42-2


UPDATE: May 2009 MW: 116.18 MF: C6H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - 2 - pentanol - 4 - one
  2. 4 - Hydroxy - 2 - keto - 4 - methylpentane
  3. 4 - Hydroxy - 4 - methyl pentan - 2 - one
  4. 4 - Hydroxy - 4 - methyl - 2 - pentanone
  5. 4 - Hydroxy - 4 - methyl - 2 - pentanone (OSHA)
  6. 4 - Hydroxy - 4 - methyl - pentan - 2 - on (German, Dutch)
  7. 4 - Hydroxy - 4 - methylpentanone - 2
  8. 4 - Idrossi - 4 - metil - pentan - 2 - one (Italian)
  9. Diacetonalcohol (Dutch)
  1. Diacetonalcool (Italian)
  2. Diacetonalkohol (German)
  3. Diacetone
  4. Diacetone alcohol
  5. Diacetone alcohol (ACGIH:OSHA)
  6. Diacetone - alcool (French)
  7. Diketone alcohol
  8. Pyranton
  9. Tyranton


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
100 ppm/15 minute N/R JIHTAB 28,262,1946
eye
rabbit
20 mg severe AJOPAA 29,1363,1946
eye
rabbit
100 ÁL/24 hour severe NTIS** OTS0557741
skin
rabbit
10 mg/24 hour open irritation test severe JIHTAB 30,63,1948
skin
rabbit
500 mg open irritation test mild UCDS** 6/29/1959


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 100,000 mg/m3/20 minute Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)
VCVGK* -,445,1994
inhalation
human
lowest published toxic concentration: 100 ppm Eye: Other eye effects

Behavioral: Headache

Gastrointestinal: Nausea or vomiting
NPIRI* 1,21,1974
inhalation
human
lowest published toxic concentration: 400 ppm Lung, Thorax, or Respiration: Other changes NPIRI* 1,21,1974
inhalation
human
lowest published toxic concentration: 475 mg/m3 Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,445,1994
inhalation
human
lowest published toxic concentration: 1,900 mg/m3 Lung, Thorax, or Respiration: Respiratory depression VCVGK* -,445,1994
inhalation
mouse
lowest published toxic concentration: 23,000 mg/m3 Brain and Coverings: Other degenerative changes VCVGK* -,445,1994
inhalation
mouse
lowest published toxic concentration: 100,000 mg/m3/20 minute Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)
VCVGK* -,445,1994
inhalation
rat
lowest published lethal concentration: 1,000 ppm/4 hour N/R NTIS** OTS0557741
inhalation
rat
lowest published toxic concentration: 100,000 mg/m3/20 minute Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)
VCVGK* -,445,1994
inhalation
rabbit
lowest published toxic concentration: 100,000 mg/m3/20 minute Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity)
VCVGK* -,445,1994
intramuscular
rabbit
lowest published lethal dose: 2,792 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JPETAB 33,175,1928
intraperitoneal
mouse
lethal dose (50 percent kill): 933 mg/kg N/R SCCUR* -,3,1961
intravenous
rat
lowest published lethal dose: 3,024 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma
JPETAB 33,175,1928
intravenous
rabbit
lowest published lethal dose: 2,792 mg/kg Lung, Thorax, or Respiration: Respiratory depression JPETAB 33,175,1928
oral
mouse
lethal dose (50 percent kill): 3,950 mg/kg N/R JAPMA8 45,669,1956
oral
mouse
lethal dose (50 percent kill): 3,000 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,445,1994
oral
rat
lethal dose (50 percent kill): 2,520 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Liver: Other changes
NTIS** OTS0557732
oral
rat
lethal dose (50 percent kill): 4,000 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,445,1994
oral
rabbit
lowest published lethal dose: 4,653 mg/kg Lung, Thorax, or Respiration: Respiratory depression JPETAB 33,175,1928
skin
rabbit
lethal dose (50 percent kill): 13,500 mg/kg N/R NPIRI* 1,21,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 250 mg/m3/244 day- intermittent Brain and Coverings: Changes in surface EEG

Cardiac: EKG changes not diagnostic of above
VCVGK* -,445,1994
inhalation
rat
lowest published toxic concentration: 4,494 mg/m3/6 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0536235
inhalation
rat
lowest published toxic concentration: 1,000 mg/m3/60 day- intermittent Cardiac: Arrythmias (indlucing changes in conduction) VCVGK* -,445,1994
inhalation
rat
lowest published toxic concentration: 1,000 mg/m3/122 day- intermittent Brain and Coverings: Other degenerative changes VCVGK* -,445,1994
inhalation
rat
lowest published toxic concentration: 1,000 mg/m3/244 day- intermittent Cardiac: Cardiomyopathy including infarction

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins
VCVGK* -,445,1994
oral
rat
lowest published toxic dose: 1,200 mg/kg/30 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) NTIS** OTS0557741
oral
rabbit
lowest published toxic dose: 12 mL/kg/12 day- intermittent Behavioral: General anesthetic

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,445,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (240 mg/m3) DTLVS* 3,70,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (240 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (240 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (240 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (240 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (238 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (241 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (240 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (240 mg/m3), short term exposure limit 75 ppm (360 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (240 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 96 mg/m3 (20 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 50 ppm (240 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 50 ppm (240 mg/m3);
short term exposure limit 75 ppm (360 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 120 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 50 ppm (238 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (120 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (120 mg/m3);
short term exposure limit 50 ppm (240 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (96 mg/m3),KZG- week 40 ppm (192 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (241 mg/m3);
short term exposure limit 75 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIACETONE ALCOHOL-air 10 hour time-weighted average 50 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4016;
Number of Industries 191;
Total Number of Facilities 20,435;
Number of Occupations 95;
Total Number of Employees Exposed 167,915
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4016;
Number of Industries 194;
Total Number of Facilities 20,857;
Number of Occupations 116;
Total Number of Employees Exposed 264,662;
Total Number of Female Employees Exposed 67,291


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402


REFERENCES:

CODEN
REFERENCE

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Human Data
   Primary Irritant

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