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Oxygen difluoride

RTECS #: RS2100000

CAS #: 7783-41-7


UPDATE: May 2009 MW: 54.00 MF: F2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. REFERENCES:

SYNONYMS:

  1. Fluorine monoxide
  2. Fluorine oxide
  1. Oxygen difluoride (ACGIH:OSHA)
  2. Oxygen fluoride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 5 mg/m3 (multigenerations) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) VCVN5* -,359,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 71 mg/m3/2 hour Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Acute pulmonary edema
STGNBT -,232,1999
inhalation
dog
lethal concentration (50 percent kill): 26 ppm/1 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
AMRL** TR-70-77,1970
inhalation
human
lowest published toxic concentration: 500 ppb Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion 34ZIAG -,444,1969
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 480 mg/m3/5 minute N/R VCVN5* -,359,1989
inhalation
monkey
lethal concentration (50 percent kill): 26 ppm/1 hour Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Nausea or vomiting
AMRL** TR-70-77,1970
inhalation
mouse
lethal concentration (50 percent kill): 1,500 ppb/1 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
AMRL** TR-70-77,1970
inhalation
rat
lethal concentration (50 percent kill): 2,600 ppb/1 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
AMRL** TR-70-77,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.05 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 ppm (0.1 mg/m3) DTLVS* 3,193,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.05 ppm (0.1 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.05 ppm (0.1 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.05 ppm (0.1 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.05 ppm (0.1 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.05 ppm (0.1 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA ceiling concentration 0.05 ppm (0.11 mg/m3), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit - BELGIUM short term exposure limit 0.05 ppm (0.11 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 0.05 ppm (0.1 mg/m3), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(F)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 2.5 mg(F)/m3, FEB 2006
Occupational Exposure Limit - FINLAND short term exposure limit 0.05 ppm (0.1 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 1 mg(F)/m3 (inhalable), 2005
Occupational Exposure Limit - KOREA ceiling concentration 0.05 ppm (0.1 mg/m3), 2006
Occupational Exposure Limit - MEXICO peak 0.05 ppm (0.1 mg/m3), 2004
Occupational Exposure Limit - MEXICO time-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 0.1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 0.05 ppm (0.11 mg/m3), JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.05 ppm (0.1 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.05 ppm (0.1 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.1 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg(F)/m3, 2005
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.05 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO OXYGEN DIFLUORIDE-air ceiling concentration 0.05 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

N/R


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as an oxidizer for rocker propellants

RTECS Compound Description:
   Reproductive Effector
   Human Data

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