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5 - Norbornene - 2,3 - dimethanol, 1,4,5,6,7,7 - hexachloro - , cyclic sulfite

RTECS #: RB9275000

CAS #: 115-29-7

UPDATE: May 2009 MW: 406.91 MF: C9H6Cl6O3S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,2,3,4,7,7 - Hexachlorobicyclo (2.2.1) hepten - 5,6 - bioxymethylenesulfite
  2. 1,4,5,6,7,7 - Hexachloro - 5 - norbornene - 2,3 - dimethanol cyclic sulfite
  3. 6,7,8,9,10,10 - Hexachloro - 1,5,5a,6,9,9a - hexahydro - 6,9 - methano - 2,4,3 - benzodioxathiepin - 3 - oxide
  4. 6,9 - Methano - 2,4,3 - benzodioxathiepin, 6,7,8,9,10,10 - hexahydro -
  5. BIO 5,462
  6. Benzoepin
  7. Beosit
  8. Chlorthiepin
  9. Crisulfan
  10. Devisulphan
  11. ENT 23,979
  12. Endocel
  13. Endosulfan
  14. Endosulfan (ACGIH:OSHA)
  15. Endosulphan
  16. Endotaf
  17. FMC 5462
  18. Goldenleaf tobacco spray
  19. HOE 2,671
  20. Hexachlorohexahydromethano 2,4,3 - benzodioxathiepin - 3 - oxide
  21. Hildan
  22. Insectophene
  23. Kop - thiodan
  1. Malix
  2. NCI - C00566
  3. NIA 5462
  4. Niagara 5,462
  5. OMS 570
  6. RCRA waste number P050
  7. Rasayansulfan
  8. SD - 4314
  9. Sulfurous acid, cyclic ester with 1,4,5,6,7,7 - hexachloro - 5 - norbornene - 2,3 - dimethanol
  10. Thifor
  11. Thimul
  12. Thiodan
  13. Thiodan 35
  14. Thiofor
  15. Thiomul
  16. Thionate
  17. Thionex
  18. Thiosulfan
  19. Thiosulfan tionel
  20. Thiotox
  21. Thiotox (insecticide)
  22. Tiovel
  23. alpha,beta - 1,2,3,4,7,7 - Hexachlorobicyclo (2.2.1) - 2 - heptene - 5,6 - bisoxymethylene sulfite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
hamster 		8 mg/kg ARTODN 58,152,1986
cytogenetic analysis unreported route
mouse 		1 mg/kg TGANAK 16(1),45,1982
cytogenetic analysis oral
mouse 		32 mg/kg IMSCE2 14,1125,1986
dominant lethal test intraperitoneal
mouse 		83 mg/kg/5 day- continuous MUREAV 242,1,1990
DNA damage hamster ovary 1 µmol/L/3 hour EMMUEG 47,682,2006
DNA damage human lymphocyte 0.5 µmol/L/3 hour EMMUEG 47,682,2006
mutation in microorganisms Salmonella typhimurium 1 µg/plate/30 minute EMMUEG 47,682,2006
mutation in microorganisms Saccharomyes cerevisiae 100 mg/L (-enzymatic activation step) TGANAK 18,455,1984
micronucleus test multiple
frog 		5 µg/L/48 hour- continuous MUREAV 587,67,2005
mutation in mammalian somatic cells mouse lymphocyte 18,600 µg/L EMMUEG 12,85,1988
sister chromatid exchange human lymphocyte 1 µmol/L ARTODN 52,221,1983
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		200 ppm/48 hour MUREAV 136,115,1984
sperm morphology intraperitoneal
mouse 		83 mg/kg/5 day- continuous MUREAV 242,1,1990
sperm morphology oral
rat 		75 mg/kg/10 day- intermittent MUREAV 585,50,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 45 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		APTOA6 42,150,1978
oral
rat 		lowest published toxic dose: 600 mg/kg (60 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male 		TOLED5 18(Suppl 1),139,1983
oral
rat 		lowest published toxic dose: 125 mg/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		BECTA6 58,79,1997
oral
rat 		lowest published toxic dose: 175 mg/kg (10 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		VHTODE 37,547,1995
oral
rat 		lowest published toxic dose: 42 mg/kg (15-21 day pregnant/1-21 day after birth) Reproductive: Effects on newborn: Physical HETOEA 18,583,1999
oral
rat 		lowest published toxic dose: 10 mg/kg (12-22 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Germ cell effects (in offspring)

Reproductive: Effects on newborn: Delayed effects 		ETOPFR 10,29,2001
oral
rat 		lowest published toxic dose: 150 mg/kg (30 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) BECTA6 70,285,2003
oral
rat 		lowest published toxic dose: 450 mg/kg (30 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		BECTA6 70,285,2003
oral
rat 		lowest published toxic dose: 6.2 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other neonatal measures or effects 		FEREAC 69,10443,2004
oral
rat 		lowest published toxic dose: 32 mg/kg (21 day prior to copulation-21 day after birth) Reproductive: Paternal effects: Testes, epididymis, sperm duct HETOEA 22,171,2003
oral
rat 		lowest published toxic dose: 257 mg/kg (1 day pregnant-21 day after birth) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) TOLED5 176,58,2008
oral
rat 		lowest published toxic dose: 25.6 mg/kg (1 day pregnant-21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOLED5 176,58,2008
oral
rat 		lowest published toxic dose: 220.3 mg/kg (1 day pregnant-15 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOLED5 176,58,2008
oral
rat 		lowest published toxic dose: 22 mg/kg (1 day pregnant-15 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOLED5 176,58,2008
oral
rat 		lowest published toxic dose: 15 mg/kg (6-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system 		JAPTO* 27,143,2007


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 330 mg/kg/78 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** PB223-159
subcutaneous
mouse 		lowest published toxic dose: 2 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration (50 percent kill): 90 mg/m3/4 hour N/R 85GMAT -,72,1982
inhalation
rat 		lethal concentration (50 percent kill): 80 mg/m3/4 hour N/R JOCMA7 9,35,1967
inhalation
rat 		lethal concentration (50 percent kill): 0.16 gm/m3/4 hour N/R FEREAC 69,10443,2004
intraperitoneal
hamster 		lethal dose (50 percent kill): 80 mg/kg N/R ARTODN 58,152,1986
intraperitoneal
mouse 		lethal dose (50 percent kill): 7 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Respiratory stimulation 		BECTA6 15,708,1976
intraperitoneal
rat 		lethal dose (50 percent kill): 8 mg/kg Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Contraction (isolated tissue) 		RREVAH 22,1,1968
intravenous
woman 		lowest published toxic dose: 6 µL/kg Behavioral: Muscle weakness

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		JTCTDW 34,447,1996
oral
wild bird 		lethal dose (50 percent kill): 35 mg/kg N/R TXAPA9 21,315,1972
oral
cat 		lethal dose (50 percent kill): 2 mg/kg N/R 85DPAN -,-,1971/1976
oral
duck 		lethal dose (50 percent kill): 33 mg/kg N/R DOEAAH 35,25,1979
oral
dog 		lethal dose (50 percent kill): 76,700 µg/kg N/R PEMNDP 9,332,1991
oral
domestic animal 		lethal dose (50 percent kill): 26 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		VETNAL 59(12),64,1983
oral
hamster 		lethal dose (50 percent kill): 118 mg/kg N/R EJTXAZ 7,159,1974
oral
man 		lowest published lethal dose: 429 µL/kg Eye: Miosis (pupilliary constriction)

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Urine volume decreased or anuria 		YAKUD5 34,1232,1992
oral
man 		lowest published lethal dose: 260 mg/kg Brain and Coverings: Changes in surface EEG

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) 		JTCTDW 36,345,1998
oral
man 		lowest published toxic dose: 86 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Cyanosis 		JTCTDW 26,265,1988
oral
man 		lowest published lethal dose: 418 µL/kg Olfaction: Other olfaction effects

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Pulse rate decreased with fall in BP 		AJEMEN 6,510,1988
oral
man 		lowest published lethal dose: 2,571 mg/kg Behavioral: Convulsions or effect on seizure threshold

Liver: Fatty liver degeneration

Blood: Changes in bone marrow not included in above 		JTCTDW 42,927,2004
oral
mouse 		lethal dose (50 percent kill): 7,360 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor 		TOLED5 7,221,1981
oral
rat 		lethal dose (50 percent kill): 18 mg/kg N/R ARSIM* 20,9,1966
oral
rat 		lowest published toxic dose: 3 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		FEREAC 69,10443,2004
oral
rabbit 		lethal dose (50 percent kill): 28 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		VETNAL 59(12),64,1983
oral
woman 		lowest published toxic dose: 246 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Arrythmias (indlucing changes in conduction)

Lung, Thorax, or Respiration: Acute pulmonary edema 		JTCTDW 42,927,2004
subcutaneous
rabbit 		lethal dose (50 percent kill): 360 mg/kg Behavioral: Change in motor activity (specific assay)

Gastrointestinal: Nausea or vomiting

Gastrointestinal: Contraction (isolated tissue) 		RREVAH 22,1,1968
skin
mammal (species unspecified) 		lethal dose (50 percent kill): 147 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity 		VETNAL 59(12),64,1983
skin
rat 		lethal dose (50 percent kill): 34 mg/kg N/R 85GMAT -,72,1982
skin
rabbit 		lethal dose (50 percent kill): 90 mg/kg Eye: Other eye effects

Skin: After systemic exposure: Dermatitis, irritative 		JOCMA7 9,35,1967
unreported route
mouse 		lethal dose (50 percent kill): 32 mg/kg N/R TGANAK 16(1),45,1982
unreported route
rat 		lethal dose (50 percent kill): 40 mg/kg N/R 30ZDA9 -,267,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 8.4 mg/kg/6 hour/21 day- intermittent Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 69,10443,2004
inhalation
rat 		lowest published toxic concentration: 8.4 mg/kg/6 hour/21 day- intermittent Kidney, Ureter, and Bladder: Renal function tests depressed

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		FEREAC 69,10443,2004
intraperitoneal
mouse 		lowest published toxic dose: 21.7 mg/kg/14 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum NRTXDN 28,727,2007
intraperitoneal
rabbit 		lowest published toxic dose: 650 mg/kg/65 week- intermittent Eye: Retinal changes pigmentary deposition, retinitis, other)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Conditioned vitamin deficiency 		JTOTDO 6,161,1987
intratracheal
rat 		lowest published toxic dose: 30 mg/kg/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		BECTA6 34,63,1985
oral
chicken 		lowest published toxic dose: 315 mg/kg/60 day- continuous Blood: Changes in spleen

Immunological Including Allergic: Decreased immune response 		TXAPA9 197,278,2004
oral
chicken 		lowest published toxic dose: 19.6 mg/kg/8 week- continuous Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		TOPADD 32,364,2004
oral
dog 		lowest published toxic dose: 2,745 mg/kg/0.5 year- intermittent Gastrointestinal: Other changes FEREAC 69,10443,2004
oral
dog 		lowest published toxic dose: 638.75 mg/kg/1 year- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 69,10443,2004
oral
mouse 		lowest published toxic dose: 105 mg/kg/7 day- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 148,158,1998
oral
mouse 		lowest published toxic dose: 120 mg/kg/30 day- intermittent Liver: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Other proteins 		BECTA6 71,458,2003
oral
mouse 		lowest published toxic dose: 664.3 mg/kg/13 week- intermittent Related to Chronic Data: Changes in uterine weight FEREAC 69,10443,2004
oral
mouse 		lowest published toxic dose: 1,934.5 mg/kg/2 year- intermittent Related to Chronic Data: Changes in uterine weight FEREAC 69,10443,2004
oral
rat 		lowest published toxic dose: 150 mg/kg/15 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight 		BECTA6 18,378,1977
oral
rat 		lowest published toxic dose: 450 mg/kg/60 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOLED5 21,29,1984
oral
rat 		lowest published toxic dose: 840 mg/kg/7 week- intermittent Endocrine: Hyperglycemia

Blood: Other changes

Nutritional and Gross Metabolic: Changes in: Ca 		TOLED5 5,119,1980
oral
rat 		lowest published toxic dose: 185 mg/kg/22 week- continuous Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		ARTODN 59,279,1986
oral
rat 		lowest published toxic dose: 45 mg/kg/30 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		INHEAO 22,295,1984
oral
rat 		lowest published toxic dose: 126 mg/kg/6 week- continuous Liver: Changes in liver weight

Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response 		BECTA6 38,435,1987
oral
rat 		lowest published toxic dose: 136.5 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in spleen weight 		FEREAC 69,10443,2004
oral
rat 		lowest published toxic dose: 2,482 mg/kg/2 year- intermittent Vascular: Structural changes in vessels

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FEREAC 69,10443,2004
oral
rat 		lowest published toxic dose: 28 mg/kg/2 week- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas TXCYAC 200,205,2004
oral
rat 		lowest published toxic dose: 42 mg/kg/3 week- intermittent Gastrointestinal: Changes in structure or function of exocrine pancreas

Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TXCYAC 200,205,2004
oral
rat 		lowest published toxic dose: 84 mg/kg/6 week- intermittent Cardiac: Cardiomyopathy including infarction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXCYAC 202,227,2004
oral
rat 		lowest published toxic dose: 75 mg/kg/10 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		MUREAV 585,50,2005
oral
rat 		lowest published toxic dose: 75 mg/kg/10 day- intermittent Endocrine: Androgenic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		MUREAV 585,50,2005
oral
rat 		lowest published toxic dose: 15 mg/kg/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 27,143,2007
subcutaneous
rat 		lowest published toxic dose: 250 mg/kg/10 day- intermittent Behavioral: Excitement NETEEC 24,797,2002
skin
rat 		lowest published toxic dose: 567 mg/kg/21 day- intermittent Related to Chronic Data: Changes in uterine weight FEREAC 69,10443,2004
unreported route
rat 		lowest published toxic dose: 50 mg/kg/4 day- intermittent Endocrine: Hyperglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		HBPTO* 1,879,2001
unreported route
rat 		lowest published toxic dose: 50 mg/kg/4 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Effect on Na-K pump 		HBPTO* 1,879,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 557,109,2004
TOXICOLOGY REVIEW
RREVAH 56,107,1975
TOXICOLOGY REVIEW
TXCYAC 13,115,1979
TOXICOLOGY REVIEW
ETOPFR 7,156,2002
TOXICOLOGY REVIEW
GISAAA -,18,1993
TOXICOLOGY REVIEW
TOLED5 127,29,2002
TOXICOLOGY REVIEW
MUREAV 562,77,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
BPCEM* 16,105,2002
TOXICOLOGY REVIEW
ENTOX* -,174,2005
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
FEREAC 71,24615,2006
TOXICOLOGY REVIEW
REPTED 26,1,2008
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
SIMEJ* 47,1030,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,117,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 (skin) DTLVS* 3,97,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1910.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, FEB2006
Occupational Exposure Limit - INDIA time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 mg/m3;
short term exposure limit 0.3 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3;
short term exposure limit 0.3 mg/m3 (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ENDOSULFAN-air 10 hour time-weighted average 0.1 mg/m3 (Sk) NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 28880;
Number of Industries 1;
Total Number of Facilities 43;
Number of Occupations 8;
Total Number of Employees Exposed 605
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 28880;
Number of Industries 1;
Total Number of Facilities 291;
Number of Occupations 1;
Total Number of Employees Exposed 3,205


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108023)
Used as an insecticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-62,1977


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705)
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BPCEM* Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IMSCE2 IRCS Medical Science. (Lancaster, UK) V.12-14, 1984-86. For publisher information, see MSCREJ.
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9, 1957-67. For publisher information, see:JJOMDZ
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SIMEJ*
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as an insecticide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 6994-04-3
ALT CAS #: 8003-45-0
 Click Here for Additional Information about RTECS

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