2-Naphthylamine

RTECS #

QM2100000

CAS #

91-59-8
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

143.20

Molecular Formula

C₁₀H₉N

Synonyms

2-Aminonaftalen (Czech)
2-Aminonaphthalene
2-AN
2-Naftylamin (Czech)
2-Naftylamine (Dutch)
2-Naphthalamine
2-Naphthalenamine
2-Naphthylamin (German)
2-Naphthylamine mustard
6-Naphthylamine
beta-Naftalamin (Czech)
beta-Naftilamina (Italian)
beta-Naftylamin (Czech)
beta-Naftyloamina (Polish)
beta-Naphthylamin (German)
beta-Naphthylamine
beta-Naphthylamine (ACGIH:OSHA)
C.I. 37270
Fast Scarlet Base B
RCRA waste number U168
USAF CB-22

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
body fluid assay	Salmonella typhimurium/rat	250 µmol/kg	TXCYAC 16,113,1980
Cytogenetic Analysis	intraperitoneal/rat	6 mg/kg/72H	NULSAK 23,36,1980
Cytogenetic Analysis	liver/rat	50 mg/L	PMRSDJ 1,570,1981
Cytogenetic Analysis	multiple/non-mammalian species	2500 µg/L	MUREAV 319,223,1993
Cytogenetic Analysis	ovary/hamster	3330 µg/L	PMRSDJ 1,551,1981
DNA adduct	Ascites tumor/mouse	30 µmol/L	MUREAV 89,95,1981
DNA adduct	oral/Dog	60 µmol/kg	EVHPAZ 49,125,1983
DNA adduct	oral/Dog	8 mg/kg	CRNGDP 2,467,1981
DNA adduct	/Escherichia coli	30 µmol/L	MUREAV 89,95,1981
DNA Damage	/Bacillus subtilis	2 mg/disc	PMRSDJ 1,175,1981
DNA Damage	/Other microorganisms	1 mmol/L	MUREAV 368,235,1996
DNA Damage	fibroblast/human	50 µmol/L	MUREAV 127,107,1984
DNA Damage	intraperitoneal/rat	1390 µmol/kg	CRNGDP 2,1317,1981
DNA Damage	liver/rat	300 µmol/L	MUREAV 113,357,1983
DNA Damage	lymphocyte/mammal (species unspecified)	1 mmol/L	MUREAV 368,235,1996
DNA Damage	other cell types/rat	0.25 mmol/L/20H	TXCYAC 179,115,2002
DNA Damage	other cell types/human	0.5 mmol/L/20H	TXCYAC 179,115,2002
DNA Damage	oral/mouse	400 mg/kg	MUREAV 440,1,1999
DNA inhibition	intraperitoneal/mouse	20 gm/kg	ARGEAR 51,605,1981
DNA inhibition	HeLa cell/human	200 µmol/L	MUREAV 92,427,1982
DNA inhibition	HeLa cell/human	20 mmol/L	MUREAV 93,447,1982
DNA inhibition	liver/rat	10 µmol/L	CNREA8 45,337,1985
DNA repair	/Saccharomyes cerevisiae	50 mg/L	PMRSDJ 1,502,1981
DNA repair	/Bacillus subtilis	5 gm/L	MUREAV 42,19,1977
DNA repair	/Escherichia coli	25 mg/L	JJIND8 62,873,1979
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	50 ppm	PMRSDJ 1,481,1981
host-mediated assay	Escherichia coli/mouse	200 mg/kg	MUREAV 272,161,1992
micronucleus test	other cell types/mouse	229.16 mg/L/4H (+enzymatic activation step)	MUTAEX 14,403,1999
micronucleus test	multiple/non-mammalian species	2500 µg/L	MUREAV 283,157,1992
micronucleus test	intraperitoneal/mouse	100 mg/kg	PMRSDJ 1,698,1981
micronucleus test	oral/mouse	300 mg/kg/3D-continuous	MUREAV 234,161,1990
morphological transform	embryo/mouse	1 mg/L	JNCIAM 52,1167,1974
morphological transform	mammary gland/mouse	1 µg/L	CNREA8 39,1784,1979
morphological transform	oral/rat	400 mg/kg	CNREA8 40,1157,1980
morphological transform	embryo/rat	5 mg/L	JNCIAM 51,799,1973
morphological transform	other cell types/human	68 mg/L	ITCSAF 17,719,1981
morphological transform	embryo/mouse	5 mg/L/72H	MUREAV 702,100,2010
morphological transform	fibroblast/mouse	3 mg/L/10D	MUREAV 702,100,2010
morphological transform	embryo/hamster	45 mg/L/7D	MUREAV 755,108,2013
morphological transform	embryo/hamster	1600 µg/L	CRNGDP 1,323,1980
morphological transform	kidney/hamster	25 mg/L	PMRSDJ 1,638,1981
mutation in mammalian somatic cells	lymphocyte/mouse	225 mg/L	PMRSDJ 1,580,1981
mutation in mammalian somatic cells	ovary/hamster	50 mg/L	MUREAV 94,449,1982
mutation in microorganisms	/Salmonella typhimurium	640 mg/L/65H (+enzymatic activation step)	EMMUEG 57,687,2016
mutation in microorganisms	/Salmonella typhimurium	20 µg/plate/20M (+enzymatic activation step)	MUREAV 498,19,2001
mutation in microorganisms	/Salmonella typhimurium	1 nmol/plate/20M	EMMUEG 38,268,2001
mutation in microorganisms	/Salmonella typhimurium	4 mg/L/72H (+enzymatic activation step)	MUREAV 558,181,2004
mutation in microorganisms	/Neurospora crassa	200 µmol/L (-enzymatic activation step)	CNREA8 32,1890,1972
mutation in microorganisms	/Saccharomyes cerevisiae	698 µmol/L (-enzymatic activation step)	MGGEAE 174,39,1979
mutation in microorganisms	/Saccharomyes cerevisiae	89 mg/L (+enzymatic activation step)	PMRSDJ 1,414,1981
mutation in microorganisms	/Escherichia coli	1 µg/plate (+enzymatic activation step)	PMRSDJ 1,387,1981
mutation in microorganisms	/Salmonella typhimurium	2500 ng/plate (+enzymatic activation step)	PMRSDJ 1,261,1981
mutation in microorganisms	/Salmonella typhimurium	2 µg/plate (-enzymatic activation step)	BECTA6 17,739,1977
mutation in microorganisms	/Bacillus subtilis	5 gm/L (+enzymatic activation step)	MUREAV 42,19,1977
mutation in microorganisms	lymphocyte/mouse	4720 µg/L (+enzymatic activation step)	EMMUEG 12(Suppl 13),37,1988
other mutation test systems	/Escherichia coli	7 nmol/tube	MUREAV 147,79,1985
phage inhibition capacity	/Escherichia coli	25 mg/L	CNREA8 41,532,1981
sex chromosome loss and nondisjunction	/Saccharomyes cerevisiae	50 mg/L	PMRSDJ 1,468,1981
sister chromatid exchange	intraperitoneal/mouse	100 mg/kg	MUREAV 108,225,1983
sister chromatid exchange	ovary/hamster	5 mg/L	PMRSDJ 1,551,1981
specific locus test	oral/Drosophila melanogaster	700 µmol/L	CNREA8 30,195,1970
specific locus test	intraperitoneal/mouse	100 mg/kg	MUREAV 121,267,1983
Unscheduled DNA Synthesis	liver/rat	10 µmol/L	ENMUDM 3,11,1981
Unscheduled DNA Synthesis	fibroblast/human	800 µg/L	TXCYAC 21,151,1981
Unscheduled DNA Synthesis	liver/hamster	50 µmol/L	MUREAV 136,255,1984

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
implant/mouse	lowest published toxic dose: 100 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	BJCAAI 10,539,1956
intraperitoneal/mouse	lowest published toxic dose: 1500 mg/kg/8W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors	JJIND8 67,1299,1981
intraperitoneal/rat	lowest published toxic dose: 1300 mg/kg/13W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Lymphoma including Hodgkin's disease Tumorigenic: Tumors at site of application	CNREA8 28,535,1968
multiple/Dog	lowest published toxic dose: 3077 mg/kg/78W- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	AJPAA4 13,656,1937
multiple/Dog	toxic dose: 4379 mg/kg/80W- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	JIHTAB 20,46,1938
multiple/Dog	toxic dose: 5169 mg/kg/91W- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	JIHTAB 20,46,1938
oral/Dog	toxic dose: 94500 mg/kg/9Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	BJCAAI 44,892,1981
oral/Dog	lowest published toxic dose: 33600 mg/kg/168W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	VOONC* 37,60,1991
oral/Dog	toxic dose: 108 mg/kg/4Y	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	LANCAO 2,286,1951
oral/Dog	lowest published toxic dose: 18 gm/kg/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	JNCIAM 49,193,1972
oral/hamster	lowest published toxic dose: 217 mg/kg/45W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Kidney, Ureter, and Bladder: Bladder tumors	85DAAC 5,129,1966
oral/hamster	toxic dose: 365 gm/kg/43W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Kidney, Ureter, and Bladder: Bladder tumors	IMSUAI 35,564,1966
oral/monkey	lowest published toxic dose: 17 gm/kg/5Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	JNCIAM 42,825,1969
oral/mouse	toxic dose: 31 gm/kg/2Y	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors	LANCAO 2,286,1951
oral/mouse	lowest published toxic dose: 600 mg/kg/8W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Lung, Thorax, or Respiration: Tumors	TXAPA9 82,19,1986
oral/rabbit	toxic dose: 30 gm/kg/5Y	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	LANCAO 2,286,1951
oral/rabbit	lowest published toxic dose: 40 gm/kg/5Y	Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	LANCAO 2,286,1951
oral/rat	lowest published toxic dose: 17100 mg/kg/57W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	BJCAAI 46,646,1982
oral/rat	toxic dose: 16 gm/kg/52W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors Skin and Appendages: Tumors	CNREA8 37,2943,1977
oral/rat	toxic dose: 13 gm/kg/1Y- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors Reproductive: Tumorigenic effects: Testicular tumors	JNCIAM 41,985,1968
parenteral/mouse	lowest published toxic dose: 18 mg/kg	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Blood: Lymphoma including Hodgkin's disease	BECCAN 40,42,1962
subcutaneous/mouse	lowest published toxic dose: 1600 mg/kg/40W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application	VOONAW 15(2),71,1969
subcutaneous/mouse	toxic dose: 80 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Tumorigenic: Tumors at site of application	ZEKBAI 58,56,1951
subcutaneous/rat	lowest published toxic dose: 6 gm/kg/60W- intermittent	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Blood: Lymphoma including Hodgkin's disease Tumorigenic: Tumors at site of application	VOONAW 20(8),69,1974
unreported route/Dog	lowest published toxic dose: 40 gm/kg/81W	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, and Bladder: Bladder tumors	VOONAW 15(2),71,1969

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	lethal dose (50 percent kill): 200 mg/kg		NTIS** AD277-689
oral/rat	lethal dose (50 percent kill): 727 mg/kg		85JCAE -,466,1986
unreported route/Dog	lowest published lethal dose: 500 mg/kg	Lung, Thorax, or Respiration: Cyanosis Kidney, Ureter, and Bladder: Hematuria Blood: Methemoglobinemia- Carboxhemoglobinemia	XPHBAO 271,176,1941

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Control as low as possible	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Human Sufficient Evidence	IMEMDT 4,97,1974
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 4,97,1974
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 99,396,2010
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 100F,90,2012
International Agency for Research on Cancer (IARC)	Cancer Review:Human Sufficient Evidence	IMEMDT 99,396,2010
International Agency for Research on Cancer (IARC)	Cancer Review:Human Sufficient Evidence	IMEMDT 100F,90,2012
International Agency for Research on Cancer (IARC)	Cancer Review:Group 1	IMSUDL 7,261,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Group 1	IMEMDT 100F,90,2012
International Agency for Research on Cancer (IARC)	Cancer Review:Group 1	IMEMDT 99,396,2010
TOXICOLOGY REVIEW		KHZHAZ 12(2),85,1976
TOXICOLOGY REVIEW		ADCSAJ 13,271,1970
TOXICOLOGY REVIEW		BLFSBY 24,253,1983
TOXICOLOGY REVIEW		MUREAV 567,347,2004
TOXICOLOGY REVIEW		FCTOD7 44,1699,2006
TOXICOLOGY REVIEW		ENTOX* -,104,2005
TOXICOLOGY REVIEW		MUREAV 627,59,2007
TOXICOLOGY REVIEW		MUREAV 626,135,2007
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 654,114,2008
TOXICOLOGY REVIEW		JTPAE7 19,1,2006
TOXICOLOGY REVIEW		HUTOX* -,649,1996
TOXICOLOGY REVIEW		MUREAV 733,39,2012
TOXICOLOGY REVIEW		MUREAV 752,99,2013
TOXICOLOGY REVIEW		MUREAV 762,37,2014
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		FCTOD7 94,93,2016
TOXICOLOGY REVIEW		MUTAEX 33,179,2018
TOXICOLOGY REVIEW		VETOX* ,339,2018

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	Carcinogen, JUL2008
Occupational Exposure Limit-FRANCE	VME 0.001 ppm (0.005 mg/m³), C1 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARY	ceiling concentration 0.005 mg/m³, Carcinogen, SEP2000
Occupational Exposure Limit-JAPAN	1 carc, MAY2012
Occupational Exposure Limit-NEW ZEALAND	carcinogen, JAN2002
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 0 mg/m³, MAC(short term exposure limit) 0 mg/m³, JAN1999
Occupational Exposure Limit-SWEDEN	Group A Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLAND	carc 1, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	see Code of Federal Regulations (CFR) 29,1926.1109	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA)-cancer suspect agent		CFRGBR 29,1910.1009,1987

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO beta-NAPHTHYLAMINE-air	Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1009	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 50065; Number of Industries 1; Total Number of Facilities 10; Number of Occupations 1; Total Number of Employees Exposed 275; Total Number of Female Employees Exposed 265
National Occupational Hazard Survey 1974	Hazard Code 50065; Number of Industries 1; Total Number of Facilities 10; Number of Occupations 5; Total Number of Employees Exposed 420

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; E coli polA without S9
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA GENETOX PROGRAM 1988, Positive: E coli polA with S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; N crassa-forward mutation
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Naphthylamines, 5518
NTP 14th Report on Carcinogens,2016:Known to be a human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #93

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health