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Methane, trichloronitro -

RTECS #: PB6300000

CAS #: 76-06-2


UPDATE: May 2009 MW: 164.37 MF: CCl3NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acquinite
  2. Chloorpikrine (Dutch)
  3. Chloroform, nitro -
  4. Chloropicrin
  5. Chloropicrin (ACGIH:OSHA)
  6. Chloropicrine (French)
  7. Chlorpikrin (German)
  8. Cloropicrina (Italian)
  9. Dojyopicrin
  10. Dolochlor
  11. G 25
  12. KLOP
  13. Larvacide
  14. Microlysin
  1. NCI - C00533
  2. Nitrochloroform
  3. Nitrotrichloromethane (OSHA)
  4. PS
  5. Pic - Clor
  6. Picfume
  7. Picride
  8. Profume A
  9. Tri - clor
  10. Trichloornitromethaan (Dutch)
  11. Trichlornitromethan (German)
  12. Trichloronitromethane
  13. Tricloro - nitro - metano (Italian)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Escherichia coli 50 g/plate (+enzymatic activation step) SAIGBL 29,34,1987
mutation in microorganisms Salmonella typhimurium 50 g/plate (-enzymatic activation step) MUREAV 116,185,1983
other mutation test systems Escherichia coli 300 g/L MUREAV 348,147,1995
sister chromatid exchange human lymphocyte 8 mg/L TCMUD8 10,21,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 26 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NCITR* NCI-TR-65,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 800 mg/m3/20 minute Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
ZGEMAZ 106,296,1939
inhalation
dog
lowest published lethal concentration: 0.5 gm/m3/30 minute Cardiac: Cardiomyopathy including infarction

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory obstruction
TPKVAL 3,103,1961
inhalation
guinea pig
lowest published lethal concentration: 800 mg/m3/20 minute Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
ZGEMAZ 106,296,1939
inhalation
guinea pig
lowest published lethal concentration: 0.5 gm/m3/30 minute Brain and Coverings: Changes in circulation

Behavioral: Ataxia

Behavioral: Tetany
TPKVAL 3,103,1961
inhalation
human
lowest published toxic concentration: 2 mg/m3 Eye: Lacrimation

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
ZGEMAZ 106,296,1939
inhalation
human
lowest published lethal concentration: 2,000 mg/m3/10 minute N/R 34ZIAG -,169,1969
inhalation
mouse
lethal concentration (50 percent kill): 66 mg/m3/4 hour Eye: Increased intraocular pressure

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation
SAIGBL 15,406,1973
inhalation
mouse
lowest published toxic concentration: 0.99 ppm/30 minute Blood: Hemorrhage TOXID9 60,426,2001
inhalation
mouse
lowest published lethal concentration: 0.15 gm/m3/15 minute Skin: After systemic exposure: Dermatitis, other TPKVAL 3,103,1961
inhalation
rat
lethal concentration (50 percent kill): 14,400 ppb/4 hour Lung, Thorax, or Respiration: Other changes NNGADV 16,63,1991
inhalation
rat
lethal concentration : 18 ppm/4 hour Olfaction: Other olfaction effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 60,426,2001
inhalation
rat
lethal concentration : 23.5 ppm/4 hour Olfaction: Change in sensation of smell

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
TOXID9 60,426,2001
inhalation
rat
lethal concentration (50 percent kill): 18.9 ppm/4 hour Olfaction: Change in sensation of smell

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
TOXID9 60,426,2001
inhalation
rat
lowest published toxic concentration: 10.5 ppm/4 hour Gastrointestinal: Nausea or vomiting TOXID9 60,426,2001
inhalation
rat
lowest published toxic concentration: 10.5 ppm/4 hour Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 60,426,2001
inhalation
rabbit
lethal concentration (50 percent kill): 800 mg/m3/20 minute N/R FMCHA2 -,C72,1991
intraperitoneal
mouse
lethal dose (50 percent kill): 25 mg/kg N/R ENTOX* -,571,2005
intravenous
guinea pig
lethal dose (50 percent kill): 4,200 g/kg Lung, Thorax, or Respiration: Acute pulmonary edema AIPTAK 114,146,1958
oral
rat
lethal dose (50 percent kill): 250 mg/kg N/R DOWCC* -,-,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 400 mg/kg/10 day- intermittent Endocrine: Changes in thymus weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 17,125,1994
oral
rat
lowest published toxic dose: 2,880 mg/kg/90 day- intermittent Gastrointestinal: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 17,125,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
ENTOX* -,571,2005
TOXICOLOGY REVIEW
MUREAV 636,242,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,98,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.7 mg/m3) DTLVS* 3,54,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.7 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.7 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.7 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.7 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.67 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.68 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.7 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.7 mg/m3), short term exposure limit 0.3 ppm (2.1 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.7 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 0.68 mg/m3 (0.1 mL/m3), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (0.67 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (0.7 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 ppm (0.7 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.7 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.67 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.7 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.7 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.7 mg/m3),KZG- week 0.1 ppm (0.7 mg/m3),DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.7 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.68 mg/m3);
short term exposure limit 0.3 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROPICRIN-air 10 hour time-weighted average 0.1 ppm NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0419;
Number of Industries 3;
Total Number of Facilities 484;
Number of Occupations 8;
Total Number of Employees Exposed 4,843;
Total Number of Female Employees Exposed 939


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for insect and rodent control in grain elevators and bins and as a soil fumigant
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (gavage);no evidence:mouse NCITR* NCI-TR-65,1978
NCI Carcinogenesis Bioassay (gavage);inadequate studies:rat NCITR* NCI-TR-65,1978


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
ZGEMAZ Zeitschrift fuer die Gesamte Experimentelle Medizin. (Berlin, Fed. Rep. Ger.) V.1-139, 1913-65. For publisher information, see REXMAS.

Used for insect and rodent control in grain elevators and bins and as a soil fumigant

NIOSH PROFILE (FUMIGANTS), SRC, 10/77

NIOSH PROFILE (GRAIN HANDLERS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

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