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Hydrazine, phenyl -

RTECS #: MV8925000

CAS #: 100-63-0


UPDATE: May 2009 MW: 108.16 MF: C6H8N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Fenilidrazina (Italian)
  2. Fenylhydrazine (Dutch)
  3. Hydrazine - benzene
  4. Hydrazinobenzene
  1. Phenylhydrazin (German)
  2. Phenylhydrazine
  3. Phenylhydrazine (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage intraperitoneal
mouse
350 µmol/kg CNREA8 41,1469,1981
DNA repair Escherichia coli 500 ng/well MUREAV 133,161,1984
mutation in microorganisms Escherichia coli 39,100 ng/plate (-enzymatic activation step) MUREAV 412,17,1998
mutation in microorganisms other microorganisms 150 µg/L (-enzymatic activation step) MUREAV 173,233,1986
mutation in microorganisms Salmonella typhimurium 4,600 nmol/plate (+/-enzymatic activation step) CNREA8 41,1469,1981
gene conversion and mitotic recombination Saccharomyes cerevisiae 25 mg/L MUREAV 308,159,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg (17-19 day pregnant) Reproductive: Effects on newborn: Behavioral TJADAB 8,97,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
rat
lowest published toxic dose: 5,200 mg/kg/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors
GTPZAB 19(6),28,1975


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 2,120 mg/m3 N/R TLSMA6 115,59,1977
inhalation
rat
lethal concentration (50 percent kill): 2,610 mg/m3 N/R TLSMA6 115,59,1977
intraperitoneal
mouse
lethal dose (50 percent kill): 170 mg/kg N/R CNREA8 41,1469,1981
intraperitoneal
rat
lowest published toxic dose: 125 mg/kg Vascular: BP lowering not characterized in autonomic section

Blood: Changes in cell count (unspecified)

Blood: Other hemolysis with or without anemia
BPBLEO 30,661,2007
intravenous
dog
lowest published lethal dose: 120 mg/kg N/R XPHBAO 271,159,1941
oral
dog
lowest published lethal dose: 200 mg/kg N/R XPHBAO 271,159,1941
oral
guinea pig
lethal dose (50 percent kill): 80 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
HYSAAV 30(7-9),191,1965
oral
mouse
lethal dose (50 percent kill): 175 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
GISAAA 30(8),21,1965
oral
rat
lethal dose (50 percent kill): 188 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
HYSAAV 30(7-9),191,1965
oral
rat
lowest published toxic dose: 125 mg/kg Vascular: BP elevation not characterized in autonomic section TOXID9 90,61,2006
oral
rat
lowest published toxic dose: 125 mg/kg Blood: Other changes TXAPA9 225,102,2007
oral
rabbit
lethal dose (50 percent kill): 80 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
HYSAAV 30(7-9),191,1965
subcutaneous
guinea pig
lowest published toxic dose: 50 mg/kg Brain and Coverings: Changes in circulation

Vascular: Other changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 6,145,1964
subcutaneous
mouse
lowest published lethal dose: 170 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes
JIHTAB 18,1,1936
skin
rabbit
lowest published lethal dose: 90 mg/kg Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Hematuria
NTIS** OTS0546542
unreported route
frog
lowest published lethal dose: 300 mg/kg N/R XPHBAO 271,159,1941


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 150 mg/kg/3 day- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count
JJATDK 20,25,2000
intraperitoneal
rat
lowest published toxic dose: 100 mg/kg/2 day- intermittent Blood: Normocytic anemia

Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count
JAPTO* 20,25,2000
intraperitoneal
rat
lowest published toxic dose: 150 mg/kg/3 day- intermittent Blood: Changes in bone marrow not included in above JAPTO* 20,25,2000
subcutaneous
guinea pig
lowest published toxic dose: 100 mg/kg/4 day- intermittent Blood: Normocytic anemia TPKVAL 6,145,1964
subcutaneous
guinea pig
lowest published toxic dose: 150 mg/kg/7 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TPKVAL 6,145,1964
subcutaneous
guinea pig
lowest published toxic dose: 2,730 mg/kg/0.5 year- intermittent Blood: Normocytic anemia

Blood: Changes in bone marrow not included in above

Biochemical: Metabolism (intermediary): Other
TPKVAL 6,145,1964
subcutaneous
rat
lowest published toxic dose: 70 mg/kg/7 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count
JTSCDR 20,1,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 627,78,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (22 mg/m3) (skin) DTLVS* 3,207,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (22 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 5 ppm (20 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.44 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.45 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.6 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 5 ppm (22 mg/m3), Skin, JAN1999
Occupational Exposure Limit - KOREA time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (45 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 ppm (20 mg/m3);
short term exposure limit 10 ppm (45 mg/m3) (skin), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.44 mg/m3), skin, sen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.6 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (22 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 20 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (22 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (22 mg/m3), Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDRAZINES-air Carcinogen ceiling concentration 0.03 ppm/120 minute NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYLHYDRAZINE-air Carcinogen ceiling concentration 0.14 ppm/120 minute (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 57300;
Number of Industries 2;
Total Number of Facilities 56;
Number of Occupations 5;
Total Number of Employees Exposed 1,120
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 57300;
Number of Industries 2;
Total Number of Facilities 10;
Number of Occupations 7;
Total Number of Employees Exposed 212;
Total Number of Female Employees Exposed 19


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a reagent in chemical analysis and organic synthesis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phenyl hydrazine, 3518


REFERENCES:

CODEN
REFERENCE

BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used as a reagent in chemical analysis and organic synthesis

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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