Hydrazine, phenyl-
RTECS #
MV8925000
CAS #
Updated
September 2013
Molecular Weight
108.16
Molecular Formula
C6H8N2
Synonyms
Fenilidrazina (Italian)
Fenylhydrazine (Dutch)
Hydrazine-benzene
Hydrazinobenzene
Phenylhydrazin (German)
Phenylhydrazine
Phenylhydrazine (ACGIH:OSHA)
Fenylhydrazine (Dutch)
Hydrazine-benzene
Hydrazinobenzene
Phenylhydrazin (German)
Phenylhydrazine
Phenylhydrazine (ACGIH:OSHA)
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA Damage | intraperitoneal/mouse | 350 µmol/kg | CNREA8 41,1469,1981 |
| DNA repair | /Escherichia coli | 500 ng/well | MUREAV 133,161,1984 |
| gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 25 mg/L | MUREAV 308,159,1994 |
| mutation in microorganisms | /Other microorganisms | 150 µg/L (-enzymatic activation step) | MUREAV 173,233,1986 |
| mutation in microorganisms | /Salmonella typhimurium | 4600 nmol/plate (+/-enzymatic activation step) | CNREA8 41,1469,1981 |
| mutation in microorganisms | /Escherichia coli | 39100 ng/plate (-enzymatic activation step) | MUREAV 412,17,1998 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | 30 mg/kg (17-19D pregnant) | Reproductive: Effects on newborn: Behavioral | TJADAB 8,97,1973 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| subcutaneous/rat | lowest published toxic dose: 5200 mg/kg/52W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Skin and Appendages: Tumors | GTPZAB 19(6),28,1975 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lethal concentration (50 percent kill): 2120 mg/m3 | TLSMA6 115,59,1977 | |
| inhalation/rat | lethal concentration (50 percent kill): 2610 mg/m3 | TLSMA6 115,59,1977 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 170 mg/kg | CNREA8 41,1469,1981 | |
| intraperitoneal/rat | lowest published toxic dose: 125 mg/kg | Vascular: BP lowering not characterized in autonomic section Blood: Changes in cell count (unspecified) Blood: Other hemolysis with or without anemia | BPBLEO 30,661,2007 |
| intravenous/Dog | lowest published lethal dose: 120 mg/kg | XPHBAO 271,159,1941 | |
| oral/Dog | lowest published lethal dose: 200 mg/kg | XPHBAO 271,159,1941 | |
| oral/guinea pig | lethal dose (50 percent kill): 80 mg/kg | Behavioral: Excitement Behavioral: Muscle contraction or spasticity | HYSAAV 30(7-9),191,1965 |
| oral/mouse | lethal dose (50 percent kill): 175 mg/kg | Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay) | GISAAA 30(8),21,1965 |
| oral/rabbit | lethal dose (50 percent kill): 80 mg/kg | Behavioral: Excitement Behavioral: Muscle contraction or spasticity | HYSAAV 30(7-9),191,1965 |
| oral/rat | lethal dose (50 percent kill): 188 mg/kg | Behavioral: Excitement Behavioral: Muscle contraction or spasticity | HYSAAV 30(7-9),191,1965 |
| oral/rat | lowest published toxic dose: 125 mg/kg | Vascular: BP elevation not characterized in autonomic section | TOXID9 90,61,2006 |
| oral/rat | lowest published toxic dose: 125 mg/kg | Blood: Other changes | TXAPA9 225,102,2007 |
| skin/rabbit | lowest published lethal dose: 90 mg/kg | Lung, Thorax, or Respiration: Cyanosis Lung, Thorax, or Respiration: Respiratory stimulation Kidney, Ureter, and Bladder: Hematuria | NTIS** OTS0546542 |
| subcutaneous/guinea pig | lowest published toxic dose: 50 mg/kg | Brain and Coverings: Changes in circulation Vascular: Other changes Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | TPKVAL 6,145,1964 |
| subcutaneous/mouse | lowest published lethal dose: 170 mg/kg | Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Cyanosis Lung, Thorax, or Respiration: Other changes | JIHTAB 18,1,1936 |
| unreported route/frog | lowest published lethal dose: 300 mg/kg | XPHBAO 271,159,1941 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | lowest published toxic dose: 150 mg/kg/3D- intermittent | Blood: Pigmented or nucleated red blood cells Blood: Changes in bone marrow not included in above Blood: Changes in erythrocyte (RBC) count | JJATDK 20,25,2000 |
| intraperitoneal/rat | lowest published toxic dose: 100 mg/kg/2D- intermittent | Blood: Normocytic anemia Blood: Changes in other cell count (unspecified) Blood: Changes in leukocyte (WBC) count | JAPTO* 20,25,2000 |
| intraperitoneal/rat | lowest published toxic dose: 150 mg/kg/3D- intermittent | Blood: Changes in bone marrow not included in above | JAPTO* 20,25,2000 |
| intraperitoneal/rat | lowest published toxic dose: 150 mg/kg/3D- intermittent | Lung, Thorax, or Respiration: Other changes Blood: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JTPAE7 21,249,2008 |
| subcutaneous/guinea pig | lowest published toxic dose: 100 mg/kg/4D- intermittent | Blood: Normocytic anemia | TPKVAL 6,145,1964 |
| subcutaneous/guinea pig | lowest published toxic dose: 150 mg/kg/7D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TPKVAL 6,145,1964 |
| subcutaneous/guinea pig | lowest published toxic dose: 2730 mg/kg/0.5Y- intermittent | Blood: Normocytic anemia Blood: Changes in bone marrow not included in above Biochemical: Metabolism (intermediary): Other | TPKVAL 6,145,1964 |
| subcutaneous/rat | lowest published toxic dose: 70 mg/kg/7D- intermittent | Blood: Changes in bone marrow not included in above Blood: Changes in erythrocyte (RBC) count Blood: Changes in platelet count | JTSCDR 20,1,1995 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 ppm (skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | MUREAV 627,78,2007 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 5 ppm (22 mg/m3) (skin) | DTLVS* 3,207,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-ARAB Republic of Egypt | time-weighted average 5 ppm (20 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.1 ppm (0.44 mg/m3), Carcinogen, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (22 mg/m3), skin, sen, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 ppm (0.45 mg/m3), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.1 ppm (0.6 mg/m3), skin, carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | short term exposure limit 5 ppm (22 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.1 ppm (0.6 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (45 mg/m3), skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 5 ppm (20 mg/m3);short term exposure limit 10 ppm (45 mg/m3) (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.1 ppm (0.44 mg/m3), skin, sen, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.6 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.1 ppm (0.44 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | MAC(time-weighted average) 20 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 5 ppm (22 mg/m3), carc 2, skin, sen, JAN2011 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 5 ppm (22 mg/m3), JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 5 ppm (22 mg/m3), Skin, JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 ppm (22 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 ppm (22 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 ppm (22 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 ppm (22 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HYDRAZINES-air | Carcinogen ceiling concentration 0.03 ppm/120M | NIOSH* DHHS #92-100,1992 |
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYLHYDRAZINE-air | Carcinogen ceiling concentration 0.14 ppm/120M (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 57300; Number of Industries 2; Total Number of Facilities 10; Number of Occupations 7; Total Number of Employees Exposed 212; Total Number of Female Employees Exposed 19 | |
| National Occupational Hazard Survey 1974 | Hazard Code 57300; Number of Industries 2; Total Number of Facilities 56; Number of Occupations 5; Total Number of Employees Exposed 1120 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health