4-Heptanone, 2,6-dimethyl-

RTECS #

MJ5775000

CAS #

108-83-8
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

142.27

Molecular Formula

C₉H₁₈O

Synonyms

2,6-Dimethyl-4-heptanone
2,6-Dimethyl-4-heptanone (OSHA)
2,6-Dimethyl-heptan-4-on (Dutch,German)
2,6-Dimethylheptan-4-one
2,6-Dimetil-eptan-4-one (Italian)
Diisobutilchetone (Italian)
Diisobutyl ketone
Diisobutyl ketone (ACGIH:OSHA)
Di-isobutylcetone (French)
Diisobutylketon (Dutch, German)
Isobutyl ketone
Isovalerone
s-Diisopropylacetone
sym-Diisopropylacetone
Valerone

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	25 ppm/15M	mild	JIHTAB 28,262,1946
eye /rabbit	500 mg	mild	AJOPAA 29,1363,1946
skin /rabbit	10 mg/24H open irritation test	mild	JIHTAB 31,60,1949
skin /rabbit	500 mg open irritation test	mild	UCDS** 12/15/1971

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 50 ppm	Eye: Other eye effects Behavioral: Headache Gastrointestinal: Nausea or vomiting	NPIRI* 1,23,1974
inhalation/mouse	lowest published toxic concentration: 1813 mg/m³/4H	Behavioral: Alteration of classical conditioning	VCVGK* -,432,1994
inhalation/rat	Lowest published lethal concentration: 11620 mg/m³/8H		VCVGK* -,432,1994
inhalation/rat	Lowest published lethal concentration: 2000 ppm/4H		JIHTAB 31,343,1949
oral/mouse	lethal dose (50 percent kill): 1416 mg/kg		SCCUR* -,4,1961
oral/rat	lethal dose (50 percent kill): 5750 mg/kg		NPIRI* 1,23,1974
skin/rabbit	lethal dose (50 percent kill): 16120 mg/kg		JIHTAB 31,60,1949

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic concentration: 250 ppm/7H/6W- intermittent	Liver: Changes in liver weight	AMIHBC 8,377,1953
inhalation/guinea pig	lowest published toxic concentration: 9590 mg/m³/7H/30D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,432,1994
inhalation/guinea pig	lowest published toxic concentration: 1450 mg/m³/7H/30D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	VCVGK* -,432,1994
inhalation/rat	lowest published toxic concentration: 1450 mg/m³/7H/30D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	VCVGK* -,432,1994
inhalation/rat	lowest published toxic concentration: 9590 mg/m³/7H/30D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,432,1994
inhalation/rat	lowest published toxic concentration: 98 ppm/6H/9D- intermittent	Behavioral: Fluid intake Kidney, Ureter, and Bladder: Urine volume increased Kidney, Ureter, and Bladder: Other changes in urine composition	TIHEEC 3,443,1987
inhalation/rat	lowest published toxic concentration: 250 ppm/7H/6W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight	AMIHBC 8,377,1953
oral/rat	lowest published toxic dose: 30 gm/kg/3W- intermittent	Behavioral: Somnolence (general depressed activity) Liver: Changes in liver weight	NTIS** OTS0571116
oral/rat	lowest published toxic dose: 130 gm/kg/13W- intermittent	Liver: Changes in liver weight Endocrine: Hypoglycemia Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0571116
oral/rat	lowest published toxic dose: 130000 mg/kg/90D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Endocrine: Changes in adrenal weight	HPV275 -,-,2003

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 25 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		NTAPM* -,753,1995
TOXICOLOGY REVIEW		RTOPDW 60,120,2011

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,322,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 25 ppm (150 mg/m³)	DTLWS* 3,16,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 25 ppm (145 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 50 ppm (290 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 25 ppm (147 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 25 ppm (150 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 25 ppm (150 mg/m³), short term exposure limit 40 ppm (240 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 25 ppm (250 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 25 ppm (150 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 25 ppm (150 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 25 ppm (145 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 25 ppm (145 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 25 ppm (145 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 150 mg/m³, MAC(short term exposure limit) 300 mg/m³, JAN1999
Occupational Exposure Limit-SWITZERLAND	MAK-week 25 ppm (150 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 150 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 50 ppm (290 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 50 ppm (290 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 25 ppm (148 mg/m³), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 50 ppm (290 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 50 ppm (290 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 50 ppm (290 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 50 ppm (290 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIISOBUTYL KETONE-air	10H time-weighted average 25 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 25820; Number of Industries 66; Total Number of Facilities 6204; Number of Occupations 59; Total Number of Employees Exposed 72926; Total Number of Female Employees Exposed 14857
National Occupational Hazard Survey 1974	Hazard Code 25820; Number of Industries 56; Total Number of Facilities 7290; Number of Occupations 49; Total Number of Employees Exposed 55554

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones I, 1300

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health