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Glycerol

RTECS #: MA8050000

CAS #: 56-81-5


UPDATE: February 2009 MW: 92.11 MF: C3H8O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2,3 - Propanetriol
  2. 1,2,3 - Trihydroxypropane
  3. 90 Technical glycerine
  4. Citifluor AF 2
  5. Clyzerin, wasserfrei (German)
  6. Glycerin
  7. Glycerin mist
  8. Glycerin mist (ACGIH,OSHA)
  9. Glycerin, anhydrous
  10. Glycerin, synthetic
  1. Glycerine
  2. Glyceritol
  3. Glycyl alcohol
  4. Grocolene
  5. MOON
  6. Osmoglyn
  7. Star
  8. Synthetic glycerin
  9. Trihydroxypropane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 85JCAE -,207,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,207,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
rat
1 gm/kg TGANAK 19,436,1985
DNA inhibition human lymphocyte 200 mmol/L PNASA6 79,1171,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratesticular
monkey
lowest published toxic dose: 119 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
CCPTAY 39,447,1989
intratesticular
rat
lowest published toxic dose: 280 mg/kg (2 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
CCPTAY 29,291,1984
intratesticular
rat
lowest published toxic dose: 1,600 mg/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) CCPTAY 29,291,1984
intratesticular
rat
lowest published toxic dose: 862 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) LIFSAK 34,1747,1984
oral
rat
lowest published toxic dose: 100 mg/kg (1 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TGANAK 19,436,1985


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 87.5 gm/kg/25 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Facilitates action of known carcinogens
CALEDQ 229,181,2005


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lowest published lethal dose: 10 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition
NPRNAY 20,47,1978
intramuscular
rat
lowest published toxic dose: 5,000 mg/kg Kidney, Ureter, and Bladder: Renal function tests depressed EKFAE9 55,21,1992
intramuscular
rat
lowest published toxic dose: 8 mL/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 201,143,2004
intramuscular
rat
lowest published toxic dose: 4 mL/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
PHMCAA 67,41,2003
intramuscular
rat
lowest published toxic dose: 4,000 mg/kg Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 46,710,2008
intramuscular
rat
lowest published lethal dose: 10 mL/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
CEXPB9 33,119,2006
intraperitoneal
mouse
lethal dose (50 percent kill): 8,700 mg/kg Behavioral: Altered sleep time (including change in righting reflex) ARZNAD 28,1579,1978
intraperitoneal
rat
lethal dose (50 percent kill): 4,420 mg/kg Behavioral: Toxic psychosis

Cardiac: Other changes

Kidney, Ureter, and Bladder: Other changes
RCOCB8 56,125,1987
intravenous
mouse
lethal dose (50 percent kill): 4,250 mg/kg N/R JAPMA8 39,583,1950
intravenous
rat
lethal dose (50 percent kill): 5,566 mg/kg N/R ARZNAD 26,1581,1976
intravenous
rabbit
lethal dose (50 percent kill): 53 gm/kg N/R NIIRDN 6,215,1982
oral
guinea pig
lethal dose (50 percent kill): 7,750 mg/kg N/R JIHTAB 23,259,1941
oral
human
lowest published toxic dose: 1,428 mg/kg Behavioral: Headache

Gastrointestinal: Nausea or vomiting
34ZIAG -,288,1969
oral
mouse
lethal dose (50 percent kill): 4,090 mg/kg N/R FRZKAP (6),56,1977
oral
rat
lethal dose (50 percent kill): 12,600 mg/kg Behavioral: General anesthetic

Behavioral: Muscle weakness

Liver: Other changes
FEPRA7 4,142,1945
oral
rat
lethal dose (50 percent kill): 12,600 mg/kg N/R ENTOX* -,449,2005
oral
rabbit
lethal dose (50 percent kill): 27 gm/kg N/R DMDJAP 31,276,1959
subcutaneous
mouse
lethal dose (50 percent kill): 91 mg/kg N/R NIIRDN 6,215,1982
subcutaneous
rat
lethal dose (50 percent kill): 100 mg/kg N/R NIIRDN 6,215,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 560 gm/kg/8 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi EXLRDA 12,281,1987
oral
mouse
lowest published toxic dose: 2,800 mg/kg/25 week- continuous Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens
CALEDQ 155,61,2000
oral
rat
lowest published toxic dose: 96 gm/kg/30 day- intermittent Blood: Changes in leukocyte (WBC) count

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 49(10),81,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 (mist) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
INMEAF 9,-,1940
TOXICOLOGY REVIEW
TPHSDY 23,504,2002
TOXICOLOGY REVIEW
TPHSDY 24,355,2003
TOXICOLOGY REVIEW
ENTOX* -,449,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,313,1998
Mine Safety and Health Administration (MSHA) STANDARD NUISANCE PARTICULATES (mist) DTLWS* 3,20,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit - FINLAND time-weighted average 20 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 10 mg/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 10 mg/m3 (mist), 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 mg/m3 (inhalable), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 mg/m3 (mist), JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 50 mg/m3,KZG- week 100 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 10 mg/m3 (mist)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 10 mg/m3 (mist)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 35085;
Number of Industries 358;
Total Number of Facilities 86,657;
Number of Occupations 198;
Total Number of Employees Exposed 1,085,329
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 35085;
Number of Industries 310;
Total Number of Facilities 67,054;
Number of Occupations 215;
Total Number of Employees Exposed 2,135,546;
Total Number of Female Employees Exposed 1,346,631


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DMDJAP Delaware State Medical Journal. (Wilmington, DE) V.1-32(1), 1929-60. For publisher information, see DSMJAA.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EXLRDA Experimental Lung Research. (Hemisphere Publishing, c/o Taylor & Francis 1900 Frost Road, Suite 101, Bristol, PA 19007) V.1- 1980-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher information, see IOHSA5.
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NPRNAY Nephron. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1964-
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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