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Ether, bis (chloromethyl)

RTECS #: KN1575000

CAS #: 542-88-1


UPDATE: May 2009 MW: 114.96 MF: C2H4Cl2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,1' - Dichlorodimethyl ether
  2. BCME
  3. Bis (chloromethyl) ether (ACGIH:OSHA)
  4. Bis - CME
  5. Bis - chloromethyl - ether
  6. Chloro (chloromethoxy) methane
  7. Chloro (chloromethoxy) methane fume
  8. Chloromethyl ether
  1. Dichlordimethylaether (German)
  2. Dimethyl - 1,1' - dichloroether
  3. Methane, oxybis (chloro -
  4. Oxybis (chloromethane)
  5. RCRA waste number P016
  6. sym - Dichloro - dimethyl ether
  7. sym - Dichloromethyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition skin
mouse
360 mol/kg CNREA8 33,769,1973
unscheduled DNA synthesis human fibroblast 160 g/L TXCYAC 21,151,1981
unscheduled DNA synthesis skin
mouse
360 mol/kg CNREA8 33,769,1973
mutation in microorganisms Salmonella typhimurium 20 g/plate (-enzymatic activation step) BJCAAI 37,873,1978
morphological transform hamster kidney 80 g/L BJCAAI 37,873,1978
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 100 ppb/6 hour/26 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TXAPA9 58,269,1981
inhalation
mouse
toxic concentration (other than lowest) : 1 ppm/82 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Increased incidence of tumors in susceptible strains
AEHLAU 22,663,1971
inhalation
rat
lowest published toxic concentration: 100 ppb/6 hour/4 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors
AEHLAU 30,73,1975
inhalation
rat
toxic concentration (other than lowest) : 100 ppb/6 hour/6 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
PAACA3 21,106,1980
inhalation
rat
toxic concentration (other than lowest) : 100 ppb/6 hour/26 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors
TXAPA9 58,269,1981
inhalation
rat
toxic concentration (other than lowest) : 75 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors
JJIND8 68,597,1982
intraperitoneal
mouse
lowest published toxic dose: 50 mg/kg/61 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
CNREA8 35,2553,1975
subcutaneous
mouse
lowest published toxic dose: 384 mg/kg/42 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
CNREA8 40,352,1980
subcutaneous
mouse
toxic dose : 640 mg/kg/53 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
CNREA8 35,2553,1975
subcutaneous
mouse
toxic dose : 12,500 g/kg Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Other: Hair
TXAPA9 15,92,1969
subcutaneous
rat
lowest published toxic dose: 375 mg/kg/43 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 43,481,1969
skin
mouse
lowest published toxic dose: 5,520 mg/kg/23 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
AEHLAU 16,472,1968
skin
mouse
toxic dose : 11 gm/kg/44 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
JNCIAM 43,481,1969


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
hamster
lethal concentration (50 percent kill): 7 ppm/7 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage
AEHLAU 30,61,1975
inhalation
hamster
lethal concentration (50 percent kill): 33 mg/m3/7 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,280,1994
inhalation
human
lowest published toxic concentration: 14 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,280,1994
inhalation
human
lowest published lethal concentration: 470 mg/m3/1 minute Lung, Thorax, or Respiration: Other changes VCVGK* -,280,1994
inhalation
man
lowest published toxic concentration: 3 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
TJSGA8 51,596,1973
inhalation
man
lowest published lethal concentration: 100 ppm/3 minute Lung, Thorax, or Respiration: Other changes TJSGA8 51,596,1973
inhalation
mouse
lethal concentration (50 percent kill): 25 mg/m3/6 hour N/R AEHLAU 22,663,1971
inhalation
mouse
lethal concentration (50 percent kill): 35 mg/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,279,1994
inhalation
rat
lethal concentration (50 percent kill): 7 ppm/7 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage
AEHLAU 30,61,1975
inhalation
rat
lethal concentration (50 percent kill): 218 mg/m3/30 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,279,1994
inhalation
rat
lethal concentration (50 percent kill): 14 mg/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,279,1994
inhalation
rat
lethal concentration (50 percent kill): 33 mg/m3/7 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,280,1994
oral
rat
lethal dose (50 percent kill): 210 L/kg N/R AIHAAP 30,470,1969
skin
mammal (species unspecified)
lowest published toxic dose: 2 pph Skin and Appendages: Tumors VCVGK* -,280,1994
skin
rabbit
lethal dose (50 percent kill): 280 L/kg N/R AIHAAP 30,470,1969
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Corrosive VCVGK* -,280,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
hamster
lowest published toxic concentration: 0.5 mg/m3/6 hour/210 day- intermittent Lung, Thorax, or Respiration: Tumors VCVGK* -,280,1994
inhalation
mouse
lowest published toxic concentration: 6 mg/m3/130 day- intermittent Lung, Thorax, or Respiration: Tumors VCVGK* -,280,1994
inhalation
mouse
lowest published toxic concentration: 5 mg/m3/28 week- intermittent Lung, Thorax, or Respiration: Tumors VCVGK* -,280,1994
inhalation
rat
lowest published toxic concentration: 4.7 mg/m3/30 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,280,1994
inhalation
rat
lowest published toxic concentration: 0.5 mg/m3/6 hour/210 day- intermittent Lung, Thorax, or Respiration: Tumors VCVGK* -,280,1994
inhalation
rat
lowest published toxic concentration: 0.5 mg/m3/659 day- intermittent Olfaction: Tumors

Lung, Thorax, or Respiration: Other changes
VCVGK* -,280,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.001 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 4,231,1974
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 4,231,1974
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,131,1987
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
ENTOX* -,565,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.1108 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) cancer suspect agent CFRGBR 29,1910.1008,1987
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.001 ppm (0.005 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.001 ppm (0.0048 mg/m3), Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.001 ppm (0.005 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.001 ppm (0.004 mg/m3), short term exposure limit 0.003 ppm, Carcinogen,JAN1999
Occupational Exposure Limit - FRANCE VME 0.001 ppm (0.005 mg/m3), continuous1 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY ceiling concentration 0.0047 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.001 ppm (0.005 mg/m3), Carcinogen, JAN1993
Occupational Exposure Limit - KOREA time-weighted average 0.001 ppm (0.005 mg/m3), carcinogen, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.001 ppm (0.0047 mg/m3), carcinogen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.001 ppm (0.005 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN Group A Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.001 ppm (0.005 mg/m3), Carcinogen, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.001 ppm (0.005 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BIS(CHLOROMETHYL) ETHER-air Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1008 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6315;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 14;
Total Number of Female Employees Exposed 5


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/168691/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in synthesis of other organic chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
OSHA ANALYTICAL METHOD #10


REFERENCES:

CODEN
REFERENCE

AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
TJSGA8 Tijdschrift Voor Sociale Geneeskunde. (B.V. Uitgeversmaatschappij. Reflex, Mathenesserlaan 310, Rotterdam 3003, Netherlands) V.1- 1923-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in synthesis of other organic chemicals

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

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