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Ethanol, 2 - ethoxy -

RTECS #: KK8050000

CAS #: 110-80-5


UPDATE: May 2009 MW: 90.14 MF: C4H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Ethoxyethanol
  2. 2 - Ethoxyethanol (ACGIH:OSHA)
  3. Athylenglykol - monoathylather (German)
  4. Cellosolve
  5. Cellosolve (OSHA)
  6. Cellosolve solvent
  7. Celosolv (Czech)
  8. Dowanol 8
  9. Dowanol EE
  10. EGEE
  11. Ektasolve EE
  12. Ether monoethylique de l'ethylene - glycol (French)
  1. Ethyl cellosolve
  2. Ethylene glycol ethyl ether
  3. Ethylene glycol monoethyl ether
  4. Etoksyetylowy alkohol (Polish)
  5. Glycol monoethyl ether (OSHA)
  6. Jeffersol EE
  7. NCI - C54853
  8. Oxitol
  9. Poly - Solv EE
  10. RCRA waste number U227
  11. RCRA waste number U359


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
guinea pig
10 g mild JPPMAB 11,150,1959
eye
human
6,000 ppm mild PHRPA6 45,1459,1930
eye
rabbit
50 mg moderate UCDS** 5/20/1966
eye
rabbit
500 mg/24 hour mild 85JCAE -,624,1986
skin
rabbit
500 mg open irritation test mild UCDS** 5/20/1966


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 6,830 mg/L EMMUEG 10(Suppl 10),1,1987
sister chromatid exchange hamster ovary 3,170 mg/L EMMUEG 10(Suppl 10),1,1987
sperm morphology oral
rat
23,400 mg/kg/5 week- intermittent TXAPA9 84,576,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 10 ppm/6 hour (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EVHPAZ 57,33,1984
inhalation
rat
lowest published toxic concentration: 200 ppm/7 hour (1-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
SWEHDO 7(Suppl 4),66,1981
inhalation
rat
lowest published toxic concentration: 600 ppm/7 hour (7-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
NRTXDN 2,231,1981
inhalation
rat
lowest published toxic concentration: 100 ppm/7 hour (14-20 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Behavioral
TJADAB 21,58A,1980
inhalation
rat
lowest published toxic concentration: 2,270 mg/m3 (7 hour/1-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVGK* -,163,1994
inhalation
rabbit
lowest published toxic concentration: 400 ppm/6 hour (65 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct EVHPAZ 57,157,1984
inhalation
rabbit
lowest published toxic concentration: 160 ppm/7 hour (1-18 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
SWEHDO 7(Suppl 4),66,1981
inhalation
rabbit
lowest published toxic concentration: 175 ppm/6 hour (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system NTIS** OTS0571396
inhalation
rabbit
lowest published toxic concentration: 160 ppm/7 hour (1-18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system SWEHDO 7(Suppl 4),66,1981
inhalation
rabbit
lowest published toxic concentration: 617 ppm/7 hour (1-18 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Other measures of fertility
NTIS** PB83-208074
inhalation
rabbit
lowest published toxic concentration: 400 ppm/6 hour (6-18 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
NTIS** OTS0546094
oral
mouse
lowest published toxic dose: 25 gm/kg (25 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct SAIGBL 21,29,1979
oral
mouse
lowest published toxic dose: 252 gm/kg (18 week prior to copulation) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
EVHPAZ 57,85,1984
oral
mouse
lowest published toxic dose: 5,600 mg/kg (8-14 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TCMUD8 7,55,1987
oral
mouse
lowest published toxic dose: 12,600 mg/kg (8-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities
TJADAB 33,96C,1986
oral
mouse
lowest published toxic dose: 28,840 mg/kg (7-14 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 220.5 gm/kg (21 week male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) NTIS** #PB85118651
oral
mouse
lowest published toxic dose: 220.5 gm/kg (21 week prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB85118651
oral
mouse
lowest published toxic dose: 382.2 gm/kg (21 week prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) NTIS** #PB85118651
oral
mouse
lowest published toxic dose: 52.5 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB85118651
oral
rat
lowest published toxic dose: 500 mg/kg (5 day male) Reproductive: Effects on fertility: Other measures of fertility FAATDF 5,182,1985
oral
rat
lowest published toxic dose: 7,820 mg/kg (1-21 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion
ARZNAD 21,880,1971
oral
rat
lowest published toxic dose: 600 mg/kg (10-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
TOXID9 4,87,1984
oral
rat
lowest published toxic dose: 1,800 mg/kg (7-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TOXID9 4,87,1984
oral
rat
lowest published toxic dose: 4,500 mg/kg (6 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) FAATDF 7,348,1986
oral
rat
lowest published toxic dose: 17,500 mg/kg (35 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
REPTED 14,55,2000
subcutaneous
rat
lowest published toxic dose: 1,955 mg/kg (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system ARZNAD 21,880,1971
skin
rat
lowest published toxic dose: 50 gm/kg (7-16 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
DCTODJ 5,277,1982
skin
rat
lowest published toxic dose: 50 gm/kg (7-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
DCTODJ 5,277,1982
skin
rat
lowest published toxic dose: 50 gm/kg (7-16 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Urogenital system
EVHPAZ 57,69,1984
skin
rat
lowest published toxic dose: 12.5 mL/kg (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) VCVGK* -,163,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 3,000 ppm/24 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
PHRPA6 45,1459,1930
inhalation
mouse
lethal concentration (50 percent kill): 1,820 ppm/7 hour Behavioral: Analgesia

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria
JIHTAB 25,157,1943
inhalation
mouse
lowest published lethal concentration: 6,500 mg/m3/7 hour Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Ulceration or bleeding from stomach
VCVGK* -,162,1984
inhalation
rat
lethal concentration (50 percent kill): 2,000 ppm/7 hour N/R NPIRI* 1,54,1974
inhalation
rat
lethal concentration (50 percent kill): >4,000 ppm/4 hour N/R IJTOFN 21,9,2002
intraperitoneal
mouse
lethal dose (50 percent kill): 1,707 mg/kg Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
FEPRA7 6,342,1947
intraperitoneal
mouse
lethal dose (50 percent kill): 1,710 mg/kg Kidney, Ureter, and Bladder: Other changes IJTOFN 21,9,2002
intraperitoneal
rat
lethal dose (50 percent kill): 2,800 mg/kg N/R ARZNAD 21,880,1971
intravenous
mouse
lethal dose (50 percent kill): 3,900 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 21,880,1971
intravenous
rat
lethal dose (50 percent kill): 2,400 mg/kg N/R NPIRI* 1,54,1974
intravenous
rabbit
lethal dose (50 percent kill): 900 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 21,880,1971
oral
guinea pig
lethal dose (50 percent kill): 1,400 mg/kg Behavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral
guinea pig
lethal dose (50 percent kill): 950 mg/kg Behavioral: General anesthetic IJTOFN 21,9,2002
oral
guinea pig
lethal dose (50 percent kill): 1.4 gm/kg N/R ENTOX* -,289,2005
oral
human
lowest published lethal dose: 143 mg/kg N/R VCVGK* -,163,1984
oral
mouse
lethal dose (50 percent kill): 2,451 mg/kg N/R KODAK* MSDS-10,170A,1982
oral
mouse
lethal dose (50 percent kill): 4,000 mg/kg Behavioral: Tetany

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,162,1984
oral
mouse
lethal dose (50 percent kill): 2,451 mg/kg Behavioral: Tremor

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
IJTOFN 21,9,2002
oral
rat
lethal dose (50 percent kill): 2,125 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Lung, Thorax, or Respiration: Respiratory depression
GTPZAB 32(3),48,1988
oral
rat
lethal dose (50 percent kill): 2,125 mg/kg Behavioral: Tetany

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,162,1984
oral
rat
lethal dose (50 percent kill): 3,527 mg/kg Behavioral: Tremor

Behavioral: Coma

Kidney, Ureter, and Bladder: Hematuria
IJTOFN 21,9,2002
oral
rat
lethal dose (50 percent kill): 8,103 mg/kg Behavioral: Tremor

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
IJTOFN 21,9,2002
oral
rat
lethal dose (50 percent kill): 2,460 mg/kg Behavioral: General anesthetic IJTOFN 21,9,2002
oral
rat
lowest published toxic dose: 1,000 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TOXID9 44,111,2005
oral
rat
lethal dose (50 percent kill): 3 gm/kg N/R ENTOX* -,289,2005
oral
rabbit
lethal dose (50 percent kill): 1,275 mg/kg N/R GISAAA 53(10),78,1988
oral
rabbit
lethal dose (50 percent kill): 1,275 mg/kg Behavioral: Tetany

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,162,1984
oral
woman
lowest published toxic dose: 0.8 mL/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,163,1984
subcutaneous
mouse
lowest published lethal dose: 5 gm/kg N/R JPETAB 42,355,1931
subcutaneous
rat
lethal dose (50 percent kill): 3,400 mg/kg N/R ARZNAD 21,880,1971
subcutaneous
rabbit
lethal dose (50 percent kill): 2 gm/kg N/R ARZNAD 21,880,1971
skin
rat
lethal dose (50 percent kill): 3,900 mg/kg N/R TOXID9 4,180,1984
skin
rabbit
lethal dose (50 percent kill): 3.6 mg/kg N/R VCVGK* -,162,1984
unreported route
guinea pig
lethal dose (50 percent kill): 3,070 mg/kg N/R GISAAA 47(5),84,1982
unreported route
mouse
lethal dose (50 percent kill): 5,799 mg/kg N/R GISAAA 47(5),84,1982
unreported route
rat
lethal dose (50 percent kill): 7,750 mg/kg N/R GISAAA 47(5),84,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 840 ppm/7 hour/12 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Microcytosis with or without anemia

Blood: Other changes
JIHTAB 25,409,1943
inhalation
man
lowest published toxic concentration: 6.6 ppm/255 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) BJIMAG 46,399,1989
inhalation
rat
lowest published toxic concentration: 4,000 ppm/4 hour/2 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain AIHAAP 25,369,1964
inhalation
rat
lowest published toxic concentration: 1,370 mg/m3/7 hour/5 week- intermittent Blood: Changes in spleen JIHTAB 25,374,1943
inhalation
rat
lowest published toxic concentration: 1,400 mg/m3/7 hour/25 day- intermittent Blood: Changes in other cell count (unspecified) VCVGK* -,163,1994
inhalation
rat
lowest published toxic concentration: 1,470 mg/m3/6 hour/13 week- intermittent Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count

Eye: Lacrimation
VCVGK* -,163,1994
inhalation
rabbit
lowest published toxic concentration: 400 ppm/6 hour/13 week- intermittent Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
EVHPAZ 57,157,1984
inhalation
rabbit
lowest published toxic concentration: 400 ppm/6 hour/13 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
NTIS** OTS0546061
inhalation
rabbit
lowest published toxic concentration: 1,470 mg/m3/6 hour/13 week- intermittent Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count

Eye: Lacrimation
VCVGK* -,163,1994
inhalation
rabbit
lowest published toxic concentration: 1,470 mg/m3/6 hour/13 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Blood: Normocytic anemia

Eye: Lacrimation
VCVGK* -,163,1994
oral
mouse
lowest published toxic dose: 25 gm/kg/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,147,1984
oral
mouse
lowest published toxic dose: 660 gm/kg/13 week- continuous Endocrine: Effect on menstrual cycle

Endocrine: Other changes

Blood: Changes in spleen
NTPTR* NIH-93-3349
oral
mouse
lowest published toxic dose: 28,840 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,141,1984
oral
mouse
lowest published toxic dose: 220.5 gm/kg/21 week- continuous Liver: Changes in liver weight NTIS** #PB85118651
oral
mouse
lowest published toxic dose: 382.2 gm/kg/21 week- continuous Brain and Coverings: Changes in brain weight

Reproductive: Maternal effects: Menstrual cycle changes or disorders
NTIS** #PB85118651
oral
mouse
lowest published toxic dose: 220.5 gm/kg/21 week- continuous Brain and Coverings: Changes in brain weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
NTIS** #PB85118651
oral
mouse
lowest published toxic dose: 382.2 gm/kg/21 week- continuous Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Paternal effects: Testes, epididymis, sperm duct
NTIS** #PB85118651
oral
rat
lowest published toxic dose: 3,600 mg/kg/4 week- intermittent Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TOLED5 109,11,1999
oral
rat
lowest published toxic dose: 26,452 mg/kg/6 week- intermittent Behavioral: Food intake (animal)

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0570960
oral
rat
lowest published toxic dose: 25 gm/kg/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field EVHPAZ 57,147,1984
oral
rat
lowest published toxic dose: 18,655 mg/kg/13 week- continuous Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
NTPTR* NIH-93-3349
oral
rat
lowest published toxic dose: 17,500 mg/kg/5 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
REPTED 14,55,2000
oral
rat
lowest published toxic dose: 8,750 mg/kg/5 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPTED 14,55,2000
oral
rat
lowest published toxic dose: 24,500 mg/kg/7 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
REPTED 14,55,2000
oral
rat
lowest published toxic dose: 12,250 mg/kg/7 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
REPTED 14,55,2000
oral
rat
lowest published toxic dose: 7 mg/kg/2 week- continuous Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) VCVGK* -,163,1994
oral
rat
lowest published toxic dose: 2,750 mg/kg/11 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) VCVGK* -,163,1994
oral
rat
lowest published toxic dose: 342.5 mg/kg/137 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,163,1994
oral
rat
lowest published toxic dose: 342.5 mg/kg/137 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVGK* -,163,1994
oral
rat
lowest published toxic dose: 4,680 mg/kg/5 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JJTHEC 13,763,1984
oral
rat
lowest published toxic dose: 9,360 mg/kg/5 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct JJTHEC 13,763,1984
oral
rat
lowest published toxic dose: 14,040 mg/kg/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JJTHEC 13,763,1984
oral
rat
lowest published toxic dose: 1,000 mg/kg/2 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) EXMPA6 40,169,1984
oral
rat
lowest published toxic dose: 18,000 mg/kg/10 day- intermittent Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Blood: Changes in platelet count
HETOEA 24,95,2005
oral
rat
lowest published toxic dose: 18,000 mg/kg/10 day- intermittent Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Changes in testicular weight
HETOEA 24,95,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
IJTOFN 21,9,2002
TOXICOLOGY REVIEW
CRTXB2 30,307,2000
TOXICOLOGY REVIEW
CRTXB2 33,137,2003
TOXICOLOGY REVIEW
ENTOX* -,274,2005
TOXICOLOGY REVIEW
ENTOX* -,289,2005
TOXICOLOGY REVIEW
ENTOX* -,451,2005
TOXICOLOGY REVIEW
HUTOX* -,623,1996
TOXICOLOGY REVIEW
MUREAV 681,3,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (370 mg/m3) (skin) DTLWS* 3,18,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 200 ppm (740 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 200 ppm (740 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 200 ppm (740 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 200 ppm (740 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (18 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (18 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (18.5 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (185 mg/m3), short term exposure limit 100 ppm (370 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (19 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 19 mg/m3 (5 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 19 mg/m3, short term exposure limit 76 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 5 ppm (18 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 5 ppm (19 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 50 ppm (185 mg/m3);
short term exposure limit 100 ppm (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 19 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (18 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 200 ppm (740 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 20 mg/m3, MAC(short term exposure limit) 80 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 5 ppm (19 mg/m3);
short term exposure limit 10 ppm (40 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (19 mg/m3),KZG- week 40 ppm (152 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 200 ppm (740 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (37 mg/m3) (skin), 2005
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENEGLYCOL MONOETHYL ETHER-air 10 hour time-weighted average 0.5 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 31350;
Number of Industries 253;
Total Number of Facilities 43,849;
Number of Occupations 154;
Total Number of Employees Exposed 406,097
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 31350;
Number of Industries 153;
Total Number of Facilities 16,505;
Number of Occupations 106;
Total Number of Employees Exposed 264,436;
Total Number of Female Employees Exposed 72,493


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in synthesis of ETHOXYETHYL ACETATE and as solvent for NITROCELLULOSE and printing ink
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9072
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN, #39
NIOSH Analytical Method, 1994: Alcohols IV, 1403
NTP Toxicity studies, RPT# TOX-26, October 2000
OSHA ANALYTICAL METHOD #53
OSHA ANALYTICAL METHOD #79


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EXMPA6 Experimental and Molecular Pathology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HUTOX*
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJTHEC Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in synthesis of ETHOXYETHYL ACETATE and as solvent for NITROCELLULOSE and printing ink

NIOSH PROFILE (GLYCOL ETHERS), SRI, 2/77

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (GLYCOL ETHERS), SRC, 3/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Primary Irritant

ALT CAS #: 96231-36-6
Click Here for Additional Information about RTECS

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