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Ethane, 1,2 - dichloro -

RTECS #: KI0525000

CAS #: 107-06-2


UPDATE: May 2009 MW: 98.96 MF: C2H4Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2 - Bichloroethane
  2. 1,2 - DCE
  3. 1,2 - Dichloorethaan (Dutch)
  4. 1,2 - Dichlor - aethan (German)
  5. 1,2 - Dichlorethane
  6. 1,2 - Dichloroethane
  7. 1,2 - Dichloroethane (OSHA)
  8. 1,2 - Dicloroetano (Italian)
  9. 1,2 - Ethylene dichloride
  10. Aethylenchlorid (German)
  11. Bichlorure d'ethylene (French)
  12. Borer sol
  13. Brocide
  14. Chlorure d'ethylene (French)
  15. Cloruro di ethene (Italian)
  16. Destruxol borer - sol
  17. Di - chlor - mulsion
  1. Dichloremulsion
  2. Dichloro - 1,2 - ethane (French)
  3. Dutch liquid
  4. Dutch oil
  5. EDC
  6. ENT 1,656
  7. Ethane dichloride
  8. Ethyleendichloride (Dutch)
  9. Ethylene chloride
  10. Ethylene dichloride
  11. Ethylene dichloride (ACGIH:OSHA)
  12. Glycol dichloride
  13. NCI - C00511
  14. RCRA waste number U077
  15. alpha,beta - Dichloroethane
  16. sym - Dichloroethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
63 mg severe UCDS** 3/23/1970
eye
rabbit
500 mg/24 hour mild 85JCAE -,93,1986
skin
rabbit
625 mg open irritation test mild UCDS** 3/23/1970
skin
rabbit
500 mg/24 hour mild 85JCAE -,93,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay mouse
Salmonella typhimurium
80 mg/kg CBINA8 24,265,1979
cytogenetic analysis hamster lung 1 gm/L ESKHA5 (103),64,1985
dominant lethal test Drosophila melanogaster other cell types 5,000 ppm/3 day EMSAB* -,169,2003
DNA damage intraperitoneal
mouse
2 mmol/kg CRNGDP 4,1491,1983
DNA damage oral
mouse
100 mg/kg CNREA8 44,4267,1984
DNA damage oral
rat
150 mg/kg TXAPA9 62,190,1982
DNA damage inhalation
rat
150 ppm/6 hour TXAPA9 62,190,1982
DNA damage Salmonella typhimurium 7,060 Ámol/L TXAPA9 62,190,1982
DNA inhibition human lymphocyte 5 mL/L CALEDQ 13,213,1981
DNA inhibition intraperitoneal
mouse
29 mg/kg MUREAV 163,193,1986
DNA repair Escherichia coli 10 mg/plate CNREA8 34,2576,1974
unscheduled DNA synthesis rat liver 130 Ámol/L MUREAV 221,263,1989
mutation in microorganisms hamster ovary 2 mmol/L (+enzymatic activation step) MUREAV 90,183,1981
mutation in microorganisms Salmonella typhimurium 10 Ámol/plate (+enzymatic activation step) CNREA8 34,2576,1974
mutation in microorganisms Salmonella typhimurium 10 Ág/plate (-enzymatic activation step) TECSDY 15,101,1987
mutation in mammalian somatic cells hamster ovary 40 mmol/L MUREAV 90,183,1981
mutation in mammalian somatic cells human lymphocyte 100 mg/L MUREAV 142,133,1985
morphological transform hamster embryo 200 ÁL/plate EVSRBT 25,75,1982
morphological transform mouse fibroblast 0.1 pph/21 day (-enzymatic activation step) EMMUEG 35,300,2000
other mutation test systems Escherichia coli 316 mmol/L EMMUEG 19,98,1992
sex chromosome loss and nondisjunction Aspergillus nidulans 2,000 ppm MUREAV 201,401,1988
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
120 mmol/L MUREAV 285,209,1993
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster
2 ppm/96 hour- continuous EVSRBT 32,65,1985
specific locus test oral
Drosophila melanogaster
1,000 ppm MUREAV 57,163,1978
specific locus test inhalation
Drosophila melanogaster
250 mg/m3 MUREAV 252,17,1991
specific locus test intraperitoneal
mouse
300 mg/kg MUREAV 117,201,1983
sperm morphology intraperitoneal
mouse
5 mg/kg TOXID9 44,455,2005
sperm morphology intraperitoneal
mouse
50 mg/kg/5 day- intermittent EMSAB* -,169,2003


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 300 ppm/7 hour (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) BANRDU 5,149,1980
inhalation
rat
lowest published toxic concentration: 208 mg/m3/6 hour (2 week prior to copulation/1-21 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) CHYCDW 23,199,1989
inhalation
rat
lowest published toxic concentration: 57 mg/m3 (24 week prior to copulation) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
VCVGH* -,364,1990
intraperitoneal
mouse
lowest published toxic dose: 50 mg/kg (5 day pregnant) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) EMSAB* -,169,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 5 ppm/7 hour/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
BANRDU 5,3,1980
inhalation
rat
lowest published toxic concentration: 5 ppm/7 hour/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Skin and Appendages: Tumors
BANRDU 5,3,1980
oral
mouse
lowest published toxic dose: 3,536 mg/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
BANRDU 5,35,1980
oral
mouse
toxic dose : 76 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Uterine tumors
NCITR* NCI-TR-55,1978
oral
mouse
toxic dose : 38 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Uterine tumors
NCITR* NCI-TR-55,1978
oral
rat
lowest published toxic dose: 5,286 mg/kg/69 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
BANRDU 5,35,1980
oral
rat
toxic dose : 38 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Gastrointestinal: Tumors
NCITR* NCI-TR-55,1978
oral
rat
toxic dose : 18 gm/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Gastrointestinal: Tumors
NCITR* NCI-TR-55,1978
skin
mouse
lowest published toxic dose: 1,120 gm/kg/74 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
JJIND8 63,1433,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lethal concentration : >3,000 ppm/7 hour N/R JPETAB 84,53,1945
inhalation
dog
lowest published lethal concentration: 20,000 mg/m3/4 hour N/R VCVGH* -,359,1990
inhalation
guinea pig
lowest published lethal concentration: 1,500 ppm/7 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JPETAB 84,53,1945
inhalation
guinea pig
lowest published lethal concentration: 8,000 mg/m3/8 hour N/R VCVGH* -,359,1990
inhalation
human
lowest published toxic concentration: 6 mg/m3/15 minute Cardiac: Pulse rate decreased with fall in BP VCVGH* -,262,1990
inhalation
human
lowest published toxic concentration: 100 mg/m3/6 hour Gastrointestinal: Nausea or vomiting VCVGH* -,262,1990
inhalation
human
lowest published toxic concentration: 300 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Headache

Gastrointestinal: Nausea or vomiting
VCVGH* -,262,1990
inhalation
human
lowest published toxic concentration: 250,000 mg/m3/30 minute Behavioral: Somnolence (general depressed activity)

Behavioral: Headache

Gastrointestinal: Nausea or vomiting
VCVGH* -,262,1990
inhalation
mammal (species unspecified)
lethal concentration : >3,000 ppm/7 hour N/R JPETAB 84,53,1945
inhalation
man
lowest published toxic concentration: 4,000 ppm/1 hour Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Coma

Gastrointestinal: Nausea or vomiting
PCOC** -,500,1966
inhalation
monkey
lethal concentration (50 percent kill): 3,000 ppm/7 hour N/R 85JCAE -,93,1986
inhalation
monkey
lowest published toxic concentration: 18,000 mg/m3/20 minute Eye: Lacrimation

Behavioral: Ataxia
VCVGH* -,260,1990
inhalation
mouse
lowest published lethal concentration: 5 gm/m3/2 hour N/R AEPPAE 141,19,1929
inhalation
mouse
lowest published toxic concentration: 17,500 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,307,1990
inhalation
mouse
lethal concentration (50 percent kill): 1,060 mg/m3/6 hour N/R VCVGH* -,359,1990
inhalation
pig
lowest published lethal concentration: 3,000 ppm/7 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
JPETAB 84,53,1945
inhalation
rat
lethal concentration (50 percent kill): 1,000 ppm/7 hour Behavioral: Coma

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Body temperature decrease
AMIHBC 4,482,1951
inhalation
rat
lowest published lethal concentration: 81,000 mg/m3/20 minute Behavioral: Coma VCVGH* -,359,1990
inhalation
rat
lethal concentration (50 percent kill): 5,100 mg/m3/6 hour N/R VCVGH* -,359,1990
inhalation
rat
lowest published toxic concentration: 2,000 ppm/4 hour Liver: Multiple effects

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in adrenal weight
TOXID9 -,225,2008
inhalation
rat
lowest published toxic concentration: 200 ppm/4 hour Olfaction: Other olfaction effects TOXID9 -,225,2008
inhalation
rat
lowest published toxic concentration: 100 ppm/8 hour Olfaction: Other olfaction effects TOXID9 -,225,2008
inhalation
rat
lowest published toxic concentration: 200 ppm/6 hour Liver: Other changes TOXID9 -,200,2008
inhalation
rabbit
lowest published lethal concentration: 3,000 ppm/7 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
JPETAB 84,53,1945
inhalation
rabbit
lowest published toxic concentration: 250 mg/m3/40 minute Behavioral: Alteration of classical conditioning VCVGH* -,260,1990
inhalation
rabbit
lowest published toxic concentration: 8,000 mg/m3/8 hour Eye: Corneal damage VCVGH* -,366,1990
intraperitoneal
guinea pig
lowest published lethal dose: 600 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases AIHAAP 35,21,1974
intraperitoneal
mouse
lethal dose (50 percent kill): 470 mg/kg N/R ARZNAD 11,902,1961
intraperitoneal
rat
lethal dose (50 percent kill): 807 mg/kg N/R GTPZAB 26(4),26,1982
intratracheal
rat
lowest published lethal dose: 120 mg/kg N/R NTIS** OTS0520615
intravenous
dog
lowest published lethal dose: 175 mg/kg N/R QJPPAL 7,205,1934
oral
dog
lethal dose (50 percent kill): 5,700 mg/kg Eye: Lacrimation

Behavioral: General anesthetic

Behavioral: Ataxia
FAONAU 48A,91,1970
oral
dog
lethal dose (50 percent kill): 2,500 mg/kg N/R VCVGH* -,360,1990
oral
guinea pig
lethal dose (50 percent kill): 0.5 mL/kg N/R VCVGH* -,360,1990
oral
human
lowest published lethal dose: 286 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Nausea or vomiting

Liver: Fatty liver degeneration
CLCEAL 86,203,1947
oral
human
lowest published toxic dose: 428 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Nausea or vomiting
SOMEAU 22(10),132,1958
oral
man
lowest published toxic dose: 892 mg/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Liver: Jaundice, other or unclassified
WILEAR 28,983,1975
oral
man
lowest published lethal dose: 714 mg/kg Behavioral: Somnolence (general depressed activity)

Cardiac: Change in rate

Lung, Thorax, or Respiration: Cyanosis
KLWOAZ 48,822,1970
oral
mouse
lethal dose (50 percent kill): 413 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Other changes
EVHPAZ 43,41,1982
oral
mouse
lethal dose (50 percent kill): 413 mg/kg N/R VCVGH* -,359,1990
oral
rat
lethal dose (50 percent kill): 500 mg/kg N/R VCVGH* -,359,1990
oral
rat
lowest published toxic dose: 628 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 178,229,2002
oral
rat
lowest published toxic dose: 43 mg/kg Liver: Other changes TOXID9 -,200,2008
oral
rabbit
lethal dose (50 percent kill): 860 mg/kg N/R GUCHAZ 6,264,1973
oral
rabbit
lethal dose (50 percent kill): 0.7 mL/kg N/R VCVGH* -,360,1990
subcutaneous
mouse
lowest published lethal dose: 380 mg/kg N/R JPETAB 84,53,1945
subcutaneous
rat
lethal dose (50 percent kill): 1 gm/kg Eye: Lacrimation

Behavioral: General anesthetic

Behavioral: Ataxia
FAONAU 48A,91,1970
subcutaneous
rabbit
lowest published lethal dose: 1,200 mg/kg N/R QJPPAL 7,205,1934
skin
rabbit
lethal dose (50 percent kill): 2,800 mg/kg Eye: Lacrimation

Behavioral: General anesthetic

Behavioral: Ataxia
FAONAU 48A,91,1970
unreported route
human
lowest published lethal dose: 5 mg/kg N/R VCVGH* -,262,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 1,000 ppm/7 hour/11 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 28(4),113,1946
inhalation
dog
lowest published toxic concentration: 1,500 ppm/7 hour/5 day- intermittent Eye: Corneal damage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AROPAW 32,391,1944
inhalation
guinea pig
lowest published toxic concentration: 200 ppm/7 hour/25 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 28(4),113,1946
inhalation
guinea pig
lowest published toxic concentration: 1,500 ppm/7 hour/5 day- intermittent Cardiac: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 84,53,1945
inhalation
monkey
lowest published toxic concentration: 1,000 ppm/7 hour/9 week- intermittent Behavioral: Coma

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 28(4),113,1946
inhalation
mouse
lowest published toxic concentration: 200 ppm/7 hour/9 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 28(4),113,1946
inhalation
rat
lowest published toxic concentration: 200 ppm/7 hour/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 28(4),113,1946
inhalation
rat
lowest published toxic concentration: 1,500 ppm/7 hour/5 day- intermittent Lung, Thorax, or Respiration: Respiratory depression

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JPETAB 84,53,1945
inhalation
rat
lowest published toxic dose: 200 ppm/6 hour/3 day- intermittent Liver: Other changes TOXID9 -,200,2008
inhalation
rabbit
lowest published toxic concentration: 400 ppm/7 hour/19 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JIHTAB 28(4),113,1946
oral
mouse
lowest published toxic dose: 43,680 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-91-3123
oral
mouse
lowest published toxic dose: 685 mg/kg/14 day- intermittent Blood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Decrease in humoral immune response
EVHPAZ 43,41,1982
oral
rat
lowest published toxic dose: 21,840 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-91-3123
oral
rat
lowest published toxic dose: 1 gm/kg/10 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
DCTODJ 17,463,1994
oral
rat
lowest published toxic dose: 129 mg/kg/3 day- intermittent Liver: Other changes TOXID9 -,200,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 20,429,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,501,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 20,429,1979
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,501,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,501,1999
TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
AIHAAP 40(3),A46,1979
TOXICOLOGY REVIEW
VHTODE 22,31,1980
TOXICOLOGY REVIEW
DCTODJ 5,319,1982
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,151,2004
TOXICOLOGY REVIEW
MUREAV 628,67,2007
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
HUTOX* -,561,1996
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,179,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (200 mg/m3) DTLVS* 3,79,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm;
ceiling concentration 100 ppm;
peak concentration 200 ppm/5 minute/3 hour
CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (200 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 5 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (40 mg/m3), JUL2008
Occupational Exposure Limit - AUSTRIA TRK 20 mg/m3 (5 mL/m3), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (41 mg/m3), Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (4 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 10 ppm (40 mg/m3), short term exposure limit 20 ppm (80 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (40 mg/m3), continuous2 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY ceiling concentration 10 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 10 ppm (40 mg/m3), 2B carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (40 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (40 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 7 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (21 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (200 mg/m3), JAN1993
Occupational Exposure Limit - POLAND time-weighted average 50 mg/m3, short term exposure limit 60 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (4 mg/m3);
short term exposure limit 5 ppm (20 mg/m3), Skin, Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (20 mg/m3), Carcinogen, Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (200 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (21 mg/m3) (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE DICHLORIDE-air Carcinogen;
10 hour time-weighted average 1 ppm;
short term exposure limit 2 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24130;
Number of Industries 92;
Total Number of Facilities 7,148;
Number of Occupations 60;
Total Number of Employees Exposed 77,671
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24130;
Number of Industries 38;
Total Number of Facilities 2,226;
Number of Occupations 61;
Total Number of Employees Exposed 83,246;
Total Number of Female Employees Exposed 33,361


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/2001/109103/AS)
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Cell transform.-SA7/SHE
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-nondisjunction; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of VINYL CHLORIDE, and as a lead-scavenging agent in petrol
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 25, 1978, AND BULLETIN 27, 1978
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Bioassay (gavage);clear evidence:mouse,rat NCITR* NCI-TR-55,1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Toxicity studies, RPT# TOX-04, October 2000
OSHA ANALYTICAL METHOD #03


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CODEN
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Used in the production of VINYL CHLORIDE, and as a lead-scavenging agent in petrol

Top 50 chemical production: 15.94 billions lbs in 1992, 13.72 billions in 1991

NIOSH PROFILE (FUMIGANTS), SRC, 10/77

NIOSH PROFILE (GRAIN HANDLERS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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