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Ethane, 2,2 - difluoro - 1,1,1,2 - tetrachloro -

RTECS #: KI1425000

CAS #: 76-11-9


UPDATE: May 2009 MW: 203.82 MF: C2Cl4F2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,1,1,2 - Tetrachloro - 2,2 - difluoroethane
  2. 1,1,1,2 - Tetrachloro - 2,2 - difluoroethane (ACGIH:OSHA)
  3. 1,1 - Difluoro - 1,2,2,2 - tetrachloroethane
  4. 1,1 - Difluoroperchloroethane
  5. CFC 112a
  1. F 112a
  2. Halocarbon 112a
  3. R 112a
  4. Refrigerant 112a


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published lethal concentration: 40,000 mg/m3/2 hour N/R VCVGH* -,634,1990
inhalation
mouse
lethal concentration (50 percent kill): 123,000 mg/m3/2 hour N/R VCVGH* -,634,1990
inhalation
rat
lowest published lethal concentration: 20,000 ppm/30 minute Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Liver: Other changes
TXAPA9 19,1,1971
inhalation
rat
lowest published toxic concentration: 84,000 mg/m3 Behavioral: General anesthetic VCVGH* -,634,1990
inhalation
rat
lethal concentration (50 percent kill): 125,000 mg/m3/4 hour N/R VCVGH* -,634,1990
inhalation
rat
lowest published lethal concentration: 258,000 mg/m3/40 minute N/R VCVGH* -,634,1990
oral
rat
lethal dose (50 percent kill): >8 gm/kg N/R NATUAS 210,744,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 100 gm/kg/10 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Liver: Changes in liver weight
VCVGH* -,635,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 500 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 500 ppm (4170 mg/m3) DTLVS* 3,249,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm (4170 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 500 ppm (4170 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (4170 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (4170 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 500 ppm (4170 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 500 ppm (4231 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 500 ppm (4170 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 500 ppm (4170 mg/m3), short term exposure limit 625 ppm (5215 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 500 ppm (4170 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 8500 mg/m3 (1000 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 500 ppm (4170 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 500 ppm (4170 mg/m3);
short term exposure limit 626 ppm (5210 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4170 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 500 ppm (4170 mg/m3), JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 500 ppm (4200 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 500 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 500 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1,1,2-TETRACHLORO-2,2-DIFLUOROETHANE-air time-weighted average 500 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a refrigerant, corrosion inhibitor, and blowing agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 1,1,1,2-Tetrachloro-2,2-difluoroethane, 1016
NIOSH Analytical Method, 1996: 1,1,2,2-Tetrachloro-1,2-difluoroethane, 1016


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a refrigerant, corrosion inhibitor, and blowing agent

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