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Diethylenetriamine

RTECS #: IE1225000

CAS #: 111-40-0


UPDATE: May 2009 MW: 103.20 MF: C4H13N3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2 - Ethanediamine, N - (2 - aminoethyl) -
  2. 1,4,7 - Triazaheptane
  3. 2,2' - Diaminodiethylamine
  4. 2,2' - Iminobis (ethanamine)
  5. 3 - Azapentane - 1,5 - diamine
  6. Aminoethylethandiamine
  7. Bis (2 - aminoethyl) amine
  1. Bis (beta - aminoethyl) amine
  2. ChS - P 1
  3. Diethylamine, 2,2' - diamino -
  4. Diethylenetriamine (ACGIH:OSHA)
  5. Ethylamine, 2,2' - iminobis -
  6. Ethylenediamine, N - (2 - aminoethyl) -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg open irritation test moderate UCDS** 12/30/1971
skin
rabbit
500 mg moderate IYKEDH 6,170,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 70 mg/m3/4 hour N/R NTIS** OTS0556409
intraperitoneal
mouse
lethal dose (50 percent kill): 71 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Peritonitis
AMIHAB 17,129,1958
intraperitoneal
rat
lethal dose (50 percent kill): 74 mg/kg Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Peritonitis
AMIHAB 17,129,1958
oral
rat
lethal dose (50 percent kill): 1,080 mg/kg Behavioral: Convulsions or effect on seizure threshold AMIHAB 17,129,1958
skin
guinea pig
lethal dose (50 percent kill): 170 ÁL/kg N/R JIHTAB 26,269,1944
skin
rabbit
lethal dose (50 percent kill): 1,090 mg/kg N/R JIHTAB 31,60,1949
unreported route
guinea pig
lethal dose (50 percent kill): 600 mg/kg N/R GISAAA 37(7),103,1972
unreported route
mouse
lethal dose (50 percent kill): 970 mg/kg N/R GISAAA 37(7),103,1972
unreported route
rat
lethal dose (50 percent kill): 970 mg/kg N/R GISAAA 37(7),103,1972
unreported route
rabbit
lethal dose (50 percent kill): 970 mg/kg N/R GISAAA 37(7),103,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rabbit
lowest published toxic dose: 1,820 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases GISAAA 37(7),103,1972


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
JJOMDZ 15,808,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (4 mg/m3) (skin) DTLWS* 3,85,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 10 ppm (42 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 10 ppm (42 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (4.2 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (4.3 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (4 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 1 ppm (4 mg/m3), FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 4 mg/m3, short term exposure limit 4 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 1 ppm (4 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 ppm (4.2 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 ppm (4.2 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (4.5 mg/m3);
short term exposure limit 2 ppm (10 mg/m3), Skin, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (4 mg/m3), Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm (4.3 mg/m3) (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHYLENE TRIAMINE-air 10 hour time-weighted average 1 ppm (Sk) NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 25210;
Number of Industries 66;
Total Number of Facilities 2,804;
Number of Occupations 56;
Total Number of Employees Exposed 38,557
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 25210;
Number of Industries 78;
Total Number of Facilities 2,978;
Number of Occupations 74;
Total Number of Employees Exposed 94,517;
Total Number of Female Employees Exposed 15,589


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in textile finishes, fungicides, corrosion inhibitors, adhesives, asphalt additives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Diethylenetriamine, 2540
OSHA ANALYTICAL METHOD #ID-60


REFERENCES:

CODEN
REFERENCE

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJOMDZ JOM, Journal of Occupational Medicine. (American Occupational Medicine Assoc., 150 N. Wacker Dr., Chicago, IL 60606) V.10- 1968-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in textile finishes, fungicides, corrosion inhibitors, adhesives, asphalt additives

NIOSH PROFILE (AMINES, POLY), SRI, 2/77

RTECS Compound Description:
   Primary Irritant

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