Cyclohexane, methyl-

RTECS #

GV6125000

CAS #

108-87-2
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

98.21

Molecular Formula

C₇H₁₄

Synonyms

Cyclohexylmethane
Hexahydrotoluene
Methylcyclohexane
Methylcyclohexane (ACGIH:OSHA)
Metylocykloheksan (Polish)
Sextone B
Toluene hexahydride
Toluene, hexahydro-

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 µL/24H	mild	NTIS** OTS0556748
skin /rabbit	500 µL/24H	mild	NTIS** OTS0556749

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lethal concentration (16 percent kill): 35000 mg/m³/2H		VCVGH* -,84,1990
inhalation/mouse	lethal concentration (50 percent kill): 36900 mg/m³/2H		VCVGH* -,84,1990
inhalation/mouse	lethal concentration (84 percent kill): 47000 mg/m³/2H		VCVGH* -,84,1990
inhalation/rabbit	Lowest published lethal concentration: 60000 mg/m³/70M	Eye: Conjunctiva irritation Behavioral: General anesthetic Behavioral: Convulsions or effect on seizure threshold	VCVGH* -,84,1990
inhalation/rabbit	lethal concentration (50 percent kill): 15227 ppm/1H	Behavioral: General anesthetic Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands	JIHTAB 25,323,1943
inhalation/rat	Lowest published lethal concentration: 82 gm/m³/1H	Behavioral: General anesthetic Behavioral: Convulsions or effect on seizure threshold Behavioral: Ataxia	NTIS** OTS0556685
oral/mouse	lethal dose (16 percent kill): 1.28 gm/kg		VCVGH* -,85,1990
oral/mouse	lethal dose (50 percent kill): 1.2 gm/kg		VCVGH* -,85,1990
oral/mouse	lethal dose (84 percent kill): 3.4 gm/kg		VCVGH* -,85,1990
oral/rabbit	lowest published lethal dose: 4 gm/kg	Gastrointestinal: Hypermotility, diarrhea	JIHTAB 25,199,1943
oral/rat	lethal dose (50 percent kill): >3200 mg/kg		NTIS** OTS0556685
skin/rabbit	Lethal dose: >86700 mg/kg		JIHTAB 25,199,1943

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rabbit	lowest published toxic concentration: 10054 ppm/6H/2W- intermittent	Eye: Conjunctiva irritation Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JIHTAB 25,323,1943
inhalation/rat	lowest published toxic concentration: 11 gm/m³/6H/5D- intermittent	Behavioral: General anesthetic	NTIS** OTS0556685

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 400 ppm	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 500 ppm (2000 mg/m³)	DTLVS* 3,162,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 400 ppm (1610 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 400 ppm (1600 mg/m³);KZW 1600 ppm (6400 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 400 ppm (1633 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 200 ppm (805 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 400 ppm (1600 mg/m³), short term exposure limit 500 ppm (2000 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 400 ppm (1600 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 200 ppm (810 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 200 ppm (805 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 400 ppm (1600 mg/m³), MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 400 ppm (1600 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 400 ppm (1600 mg/m³);short term exposure limit 500 ppm (2000 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 400 ppm (1610 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 400 ppm (1606 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 500 mg/m³, MAC(short term exposure limit) 2000 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 50 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 400 ppm (1600 mg/m³), KZG-week 800 ppm (3200 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1600 mg/m³, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 500 ppm (2000 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 500 ppm (2000 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 500 ppm (2000 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 500 ppm (2000 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 500 ppm (2000 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 500 ppm (2000 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLCYCLOHEXANE-air	10H time-weighted average 400 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 47030; Number of Industries 12; Total Number of Facilities 1175; Number of Occupations 11; Total Number of Employees Exposed 10076; Total Number of Female Employees Exposed 14
National Occupational Hazard Survey 1974	Hazard Code 47030; Number of Industries 11; Total Number of Facilities 1733; Number of Occupations 9; Total Number of Employees Exposed 6292

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health