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Clay (kaolin)

RTECS #: GF1670500

CAS #: 1332-58-7


UPDATE: February 2009 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Altowhites
  2. Argilla
  3. Bentone
  4. China clay
  5. Emathlite
  6. Fitrol
  7. Fitrol desiccite 25
  8. Glomax
  9. Hydrite
  1. Kaolin
  2. Kaolin (ACGIH:OSHA)
  3. Kaopaous
  4. Kaophills - 2
  5. Langford
  6. Mcnamee
  7. Parclay
  8. Porcelain clay
  9. Snow tex


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 590 gm/kg (37 day prior to copulation/1-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JONUAI 107,2020,1977
oral
rat
lowest published toxic dose: 370 gm/kg (37 day prior to copulation/1-22 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on newborn: Other neonatal measures or effects
JONUAI 107,2020,1977


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
rat
lowest published toxic dose: 125 mg/kg/2 minute Brain and Coverings: Changes in cerebral spinal fluid

Brain and Coverings: Other degenerative changes

Immunological Including Allergic: Increase in cellular immune response
IJNUB7 92,9,1997
intrapleural
guinea pig
lowest published toxic dose: 150 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) INHEAO 19,85,1981
intratracheal
guinea pig
lowest published toxic dose: 150 mg/kg/2 minute Lung, Thorax, or Respiration: Fibrosis (interstitial) INDHE* 19,85,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
hamster
lowest published toxic concentration: 30 mg/m3/72 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Tumors
8COLD* 1,480,1993
inhalation
hamster
lowest published toxic concentration: 30 mg/m3/72 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Tumors
EPASR* 89-900000360
inhalation
hamster
lowest published toxic concentration: 30 mg/m3/24 week- intermittent Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Fibrosis (interstitial)
EVHPAZ 102,207,1994
inhalation
hamster
lowest published toxic concentration: 30 mg/m3/48 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Tumors
INHTE5 7,503,1995
inhalation
rat
lowest published toxic concentration: 300 mg/m3/12 week- intermittent Lung, Thorax, or Respiration: Other changes 17IPC* -,897,1990
inhalation
rat
lowest published toxic concentration: 30 mg/m3/96 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Tumors
8COLD* 1,480,1993
inhalation
rat
lowest published toxic concentration: 9 mg/m3/96 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial) 8COLD* 1,480,1993
inhalation
rat
lowest published toxic concentration: 30 mg/m3/72 week- intermittent Lung, Thorax, or Respiration: Tumors EPASR* 89-900000360
inhalation
rat
lowest published toxic concentration: 30 mg/m3/48 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial) EPASR* 89-900000360
inhalation
rat
lowest published toxic concentration: 30 mg/m3/96 week- intermittent Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Tumors
EVHPAZ 102,207,1994
oral
rat
lowest published toxic dose: 370 gm/kg/37 day- intermittent Blood: Normocytic anemia

Blood: Other changes

Blood: Changes in erythrocyte (RBC) count
JONUAI 107,2020,1977


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg/m3 (respirable) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
IJTOFN 22,37,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD NUISANCE PARTICULATES DTLWS* 3,21,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg/m3 (resp. dust), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 mg/m3 (respirable), OCT 2002
Occupational Exposure Limit - FRANCE VME 10 mg/m3, FEB2006
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.5 mg/m3 (respirable), 2 mg/m3 (total), APR2007
Occupational Exposure Limit - KOREA time-weighted average 10 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 mg/m3;
short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 mg/m3 (inspirable dust), JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 mg/m3 (respirable dust), JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 3 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 mg/m3 (respirable), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KAOLIN, respirable fraction-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KAOLIN, total dust-air 10 hour time-weighted average 10 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 41775;
Number of Industries 111;
Total Number of Facilities 14,181;
Number of Occupations 88;
Total Number of Employees Exposed 155,396
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1959;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 1;
Total Number of Employees Exposed 17
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6880;
Number of Industries 23;
Total Number of Facilities 1,734;
Number of Occupations 24;
Total Number of Employees Exposed 25,166;
Total Number of Female Employees Exposed 3,162
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9449;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 1,354
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9507;
Number of Industries 1;
Total Number of Facilities 62;
Number of Occupations 1;
Total Number of Employees Exposed 125
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 41775;
Number of Industries 240;
Total Number of Facilities 43,700;
Number of Occupations 156;
Total Number of Employees Exposed 745,593;
Total Number of Female Employees Exposed 114,032


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as thickeners, opacifiers, extenders in polymer systems
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

17IPC* Proceedings of the VIIth International Pneumoconioses Conference, Pittsburgh, Pennsylvania, August 23-26, 1988. NIOSH, U.S. Department of Health and Human Services, DHHS (NIOSH).
8COLD* Proceedings, Eighth International Conference on Occupational Lung Diseases, Prague, Czechoslovakia, September 14-17, 1993
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
IJNUB7 International Journal of Neuroscience. (Gordon & Breach Science Pub. S.A., 50 W. 23rd St., New York, NY 10010) V.1- 1970-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
INDHE* Industrial Health (journal) V.19- 1981-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used as thickeners, opacifiers, extenders in polymer systems

FDA-over the counter drug

RTECS Compound Description:
   Drug
   Reproductive Effector
   Natural Product

Click Here for Additional Information about RTECS

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