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Butyl alcohol

RTECS #: EO1400000

CAS #: 71-36-3


UPDATE: May 2009 MW: 74.14 MF: C4H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 - Butanol
  2. 1 - Butyl alcohol
  3. 1 - Hydroxybutane
  4. Alcool butylique (French)
  5. Butan - 1 - ol
  6. Butanol
  7. Butanolen (Dutch)
  8. Butanolo (Italian)
  9. Butyl hydroxide
  10. Butylowy alkohol (Polish)
  11. Butyric or normal primary butyl alcohol
  1. CCS 203
  2. Hemostyp
  3. Methylolpropane
  4. Propylcarbinol
  5. Propylmethanol
  6. RCRA waste number U031
  7. n - Butanol
  8. n - Butanol (ACGIH)
  9. n - Butan - 1 - ol
  10. n - Butyl alcohol
  11. n - Butyl alcohol (OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
50 ppm N/R JIHTAB 25,282,1943
eye
rabbit
2 mg severe AJOPAA 29,1363,1946
eye
rabbit
2 mg/24 hour severe 85JCAE -,193,1986
skin
rabbit
20 mg/24 hour moderate 85JCAE -,193,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
sex chromosome loss and nondisjunction Aspergillus nidulans 7,000 ppm MUREAV 215,187,1989
sex chromosome loss and nondisjunction hamster lung 100 mmol/L MUREAV 182,135,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 6,000 ppm/7 hour (1-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 12,469,1989
inhalation
rat
lowest published toxic concentration: 8,000 ppm/7 hour (1-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FAATDF 12,469,1989
oral
rat
lowest published toxic dose: 35,295 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
ONGZAC 22(1),71,1991
oral
rat
lowest published toxic dose: 35,295 mg/kg (1-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Biochemical and metabolic
ONGZAC 22(1),71,1991
oral
rat
lowest published toxic dose: 23,100 mg/kg (8 week prior to copulation/0-20 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
IOMHEZ 7,365,1994
oral
rat
lowest published toxic dose: 113 gm/kg (1-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TOXID9 44,58,2005


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
lowest published toxic dose: 72.5 mg/m3 Eye: Conjunctiva irritation VCVGK* -,103,1984
inhalation
human
lowest published toxic concentration: 25 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
JIHTAB 25,282,1943
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 28,400 mg/m3 N/R GISAAA 51(5),61,1986
inhalation
mouse
lowest published toxic concentration: 500 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
rat
lethal concentration (50 percent kill): 8,000 ppm/4 hour N/R NPIRI* 1,10,1974
inhalation
rat
lowest published toxic concentration: 1,500 mg/m3 Lung, Thorax, or Respiration: Other changes VCVGK* -,101,1984
inhalation
rat
lowest published toxic concentration: 4,600 mg/m3/4 hour Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VCVGK* -,101,1984
inhalation
rat
lowest published toxic concentration: 7,400 mg/m3/4 hour Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VCVGK* -,101,1984
inhalation
rat
lethal concentration (50 percent kill): 24,000 mg/m3/4 hour N/R VCVGK* -,101,1984
intraperitoneal
mouse
lethal dose (50 percent kill): 254 mg/kg Liver: Other changes RCOCB8 26,75,1979
intraperitoneal
rat
lethal dose (50 percent kill): 200 mg/kg N/R VCVGK* -,101,1984
intraperitoneal
rat
lowest published toxic dose: 400 mg/kg Behavioral: Ataxia VCVGK* -,101,1984
intravenous
cat
lowest published lethal dose: 243 mg/kg N/R JPETAB 16,1,1920
intravenous
mouse
lethal dose (50 percent kill): 377 mg/kg N/R AIPTAK 135,330,1962
intravenous
rat
lethal dose (50 percent kill): 310 mg/kg N/R EVHPAZ 61,321,1985
oral
wild bird
lethal dose (50 percent kill): 2,500 mg/kg N/R AECTCV 12,355,1983
oral
dog
lowest published lethal dose: 1,760 mg/kg Gastrointestinal: Other changes

Blood: Hemorrhage
COREAF 81,192,1875
oral
hamster
lethal dose (50 percent kill): 1,200 mg/kg N/R VCVGK* -,102,1984
oral
human
lowest published lethal dose: 428 mg/kg N/R VCVGK* -,103,1984
oral
mouse
lethal dose (50 percent kill): 100 mg/kg N/R VCVGK* -,101,1984
oral
rat
lethal dose (50 percent kill): 790 mg/kg Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
SAMJAF 43,795,1969
oral
rat
lethal dose (50 percent kill): 790 mg/kg N/R TOVEFN (4),39,2003
oral
rabbit
lethal dose (50 percent kill): 3,484 mg/kg Eye: Corneal damage

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Dyspnea
IMSUAI 41,31,1972
oral
rabbit
lethal dose (50 percent kill): 3,400 mg/kg N/R VCVGK* -,102,1984
subcutaneous
dog
lowest published lethal dose: 2 gm/kg Gastrointestinal: Other changes

Blood: Hemorrhage
COREAF 81,192,1875
subcutaneous
mouse
lethal dose (50 percent kill): 3,200 mg/kg N/R TXAPA9 18,185,1971
skin
rabbit
lethal dose (50 percent kill): 3,400 mg/kg N/R NPIRI* 1,10,1974
unreported route
rabbit
lowest published lethal dose: 3,500 mg/kg N/R THMOAM 6,327,1892


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 5 mg/m3/4 hour/5 week- intermittent Liver: Changes in liver weight VCVGK* -,103,1994
inhalation
mouse
lowest published toxic concentration: 6,600 g/m3/24 hour/17 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Other changes
GISAAA 41(11),12,1976
inhalation
rat
lowest published toxic concentration: 6,600 g/m3/24 hour/17 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Vascular: Regional or general arteriolar or venous dilation

Liver: Liver function tests impaired
GISAAA 41(11),12,1976
inhalation
rat
lowest published toxic concentration: 2,000 ppm/6 hour/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
ATSUDG 8,418,1985
inhalation
rat
lowest published toxic concentration: 212 mg/m3/5 hour/26 week- intermittent Immunological Including Allergic: Increase in cellular immune response VCVGK* -,103,1994
inhalation
rat
lowest published toxic concentration: 6.6 mg/m3/5 hour/122 day- intermittent Brain and Coverings: Other degenerative changes VCVGK* -,103,1994
inhalation
rat
lowest published toxic concentration: 20 mg/m3/24 hour/90 day- continuous Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes
VCVGK* -,103,1994
inhalation
rat
lowest published toxic concentration: 1.36 mg/m3/30 day- continuous Brain and Coverings: Other degenerative changes TOLED5 135,S122,2002
inhalation
rat
lowest published toxic concentration: 14.6 mg/m3/30 day- continuous Liver: Multiple effects

Endocrine: Changes in adrenal weight
TOLED5 135,S122,2002
oral
rat
lowest published toxic dose: 46,500 mg/kg/13 week- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0531032
oral
rat
lowest published toxic dose: 7 mL/kg/7 day- intermittent Liver: Other changes

Biochemical: Effect on specific coenzyme: B vitamins including folate
JDGRAX 10(1-2),25,1978
oral
rat
lowest published toxic dose: 1 mg/kg/5 day- intermittent Endocrine: Changes in adrenal weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TOLED5 135,S122,2002
oral
rat
lowest published toxic dose: 4 mg/kg/20 day- intermittent Endocrine: Changes in adrenal weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TOLED5 135,S122,2002
oral
rat
lowest published toxic dose: 6 mg/kg/30 day- intermittent Endocrine: Changes in adrenal weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TOLED5 135,S122,2002
oral
rat
lowest published toxic dose: 113,080 mg/kg/20 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 44,58,2005
subcutaneous
rat
lowest published toxic dose: 157 mg/kg/4 day- intermittent Behavioral: Ataxia NETEEC 10,81,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 20 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
JACTDZ 6(3),403,1987
TOXICOLOGY REVIEW
TOLED5 140-141,239,2003
TOXICOLOGY REVIEW
MUREAV 628,67,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (300 mg/m3) DTLVS* 3,31,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA ceiling concentration 50 ppm (152 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (154 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 50 ppm (150 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (150 mg/m3), short term exposure limit 75 ppm (225 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 50 ppm (150 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 310 mg/m3 (100 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 45 mg/m3, short term exposure limit 90 mg/m3, Skin, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 50 ppm (150 mg/m3), Skin, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit- continuous 50 ppm (150 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA ceiling concentration 50 ppm (150 mg/m3), 2006
Occupational Exposure Limit - MEXICO peak 50 ppm (150 mg/m3) (skin), 2004
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 50 ppm (150 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (75 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - POLAND time-weighted average 50 mg/m3, short term exposure limit 140 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 15 ppm (45 mg/m3), ceiling concentration 30 ppm (90 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (150 mg/m3);
KZG- week 50 ppm (150 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 50 ppm (154 mg/m3) (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 20 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 20 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-BUTYL ALCOHOL-air ceiling concentration 50 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 13850;
Number of Industries 306;
Total Number of Facilities 60,975;
Number of Occupations 160;
Total Number of Employees Exposed 678,026
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 13850;
Number of Industries 304;
Total Number of Facilities 57,416;
Number of Occupations 179;
Total Number of Employees Exposed 1,059,965;
Total Number of Female Employees Exposed 269,422


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols II, 1401
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
IOMHEZ International Journal of Occupational Medicine and Environmental Health. (Nofer Institute of Occupational Medicine, 8 SW. Teresy Street, P.O. Box 199, 90-950 Lodz, Poland) V.7- 1994-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
ONGZAC Ontogenez (Moscow). For English translation, see SJDBA9. (V/O Mezhdunarodnaya Kniga, 113095, Moscow, USSR) V.1- 1970-
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
THMOAM Therapeutische Monatshefte. (Berlin, Germany) V.1-33, 1887-1919. For publisher information, see KLWOAZ.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 42031-19-6
ALT CAS #: 107569-51-7
ALT CAS #: 220713-25-7
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