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2 - Butanone, 3 - methyl -

RTECS #: EL9100000

CAS #: 563-80-4


UPDATE: May 2009 MW: 86.15 MF: C5H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Acetyl propane
  2. 3 - Methyl - 2 - butanone
  3. 3 - Methylbutanone
  4. Isopropyl methyl ketone
  1. MIPK
  2. Methyl isopropyl ketone
  3. Methyl isopropyl ketone (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour mild FCTXAV 16,819,1978
eye
rabbit
500 mg/24 hour mild 85JCAE -,282,1986
skin
rabbit
500 mg/24 hour moderate FCTXAV 16,819,1978
skin
rabbit
500 mg open irritation test mild FCTXAV 16,637,1978


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
gene conversion and mitotic recombination Saccharomyes cerevisiae 12,300 ppm MUREAV 149,339,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 30,000 mg/m3 Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,422,1994
inhalation
rat
lowest published lethal concentration: 5,700 ppm/4 hour N/R TXAPA9 28,313,1974
intraperitoneal
mouse
lethal dose (50 percent kill): 200 mg/kg N/R 38MKAJ 2C,4737,1982
intraperitoneal
rat
lethal dose (50 percent kill): 800 mg/kg N/R 38MKAJ 2C,4737,1982
oral
mouse
lethal dose (50 percent kill): 2,572 mg/kg N/R TOLED5 30,13,1986
oral
mouse
lethal dose (50 percent kill): 3,000 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,422,1994
oral
rat
lethal dose (50 percent kill): 3,078 mg/kg N/R ACMIK* 1988
oral
rat
lethal dose (50 percent kill): 3,000 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,422,1994
skin
rabbit
lethal dose (50 percent kill): 6,350 mg/kg N/R FCTXAV 16,819,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (705 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (715 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 200 ppm (705 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 200 ppm (700 mg/m3), short term exposure limit 250 ppm (875 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm (705 mg/m3), FEB2006
Occupational Exposure Limit - KOREA time-weighted average 200 ppm (705 mg/m3), 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 705 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 200 ppm (705 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (350 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (720 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 200 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 200 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ISOPROPYL KETONE-air 10 hour time-weighted average 200 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83768;
Number of Industries 3;
Total Number of Facilities 68;
Number of Occupations 7;
Total Number of Employees Exposed 1,055


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a slovent for NITROCELLULOSE lacquers
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ACMIK* Acute toxicity of methyl isopropyl ketone, Toxicological Sciences Laboratory, Health and Environment Laboratories, Eastman Kodak Company, Rochester, NY; HAEL No. 88-0008, May 19, 1988.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a slovent for NITROCELLULOSE lacquers

RTECS Compound Description:
   Mutagen
   Primary Irritant

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