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1 - Butanol, 3 - methyl -

RTECS #: EL5425000

CAS #: 123-51-3


UPDATE: May 2009 MW: 88.17 MF: C5H12O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - 4 - butanol
  2. 3 - Methyl butanol
  3. 3 - Methyl - 1 - butanol
  4. 3 - Methylbutan - 1 - ol
  5. 3 - Metil - butanolo (Italian)
  6. Alcool amilico (Italian)
  7. Alcool isoamylique (French)
  8. Amylowy alkohol (Polish)
  9. Fermentation amyl alcohol
  1. Iso - amylalkohol (German)
  2. Isoamyl alcohol
  3. Isoamyl alcohol (ACGIH)
  4. Isoamyl alcohol, primary (OSHA)
  5. Isoamyl alkohol (Czech)
  6. Isoamylol
  7. Isobutylcarbinol
  8. Isopentanol
  9. Isopentyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
150 ppm N/R JIHTAB 25,282,1943
eye
rabbit
20 mg/24 hour moderate 85JCAE -,196,1986
skin
rabbit
20 mg/24 hour moderate 85JCAE -,196,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 27 gm/kg/75 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia
ARGEAR 45,19,1975
subcutaneous
rat
lowest published toxic dose: 3,800 mg/kg/85 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia
ARGEAR 45,19,1975


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 150 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
JIHTAB 25,282,1943
intraperitoneal
mouse
lowest published lethal dose: 233 mg/kg N/R FCTXAV 16,785,1978
intraperitoneal
rat
lowest published lethal dose: 813 mg/kg N/R AEPPAE 132,214,1928
intravenous
cat
lowest published lethal dose: 210 mg/kg N/R FCTXAV 16,785,1978
intravenous
mouse
lethal dose (50 percent kill): 234 mg/kg N/R AIPTAK 135,330,1962
intravenous
rabbit
lowest published lethal dose: 1,570 mg/kg Behavioral: Antipsychotic FCTXAV 16,785,1978
oral
rat
lethal dose (50 percent kill): 1,300 mg/kg Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
SAMJAF 43,795,1969
oral
rat
lethal dose (50 percent kill): 4,300 mg/kg N/R VCVGK* -,108,1984
oral
rabbit
lethal dose (50 percent kill): 3,438 mg/kg Eye: Corneal damage

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Dyspnea
IMSUAI 41,31,1972
subcutaneous
mouse
lowest published lethal dose: 7,480 mg/kg N/R FCTXAV 16,785,1978
skin
rabbit
lethal dose (50 percent kill): 3,970 ÁL/kg N/R AIHAAP 30,470,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm;short term exposure limit 125 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 539,77,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (360 mg/m3) DTLVS* 3,139,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (360 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (360 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (360 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (360 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (361 mg/m3), short term exposure limit 125 ppm (452 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm(366 mg/m3), short term exposure limit 125 ppm(459 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 100 mg/m3 (360 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 100 ppm (360 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 370 mg/m3 (100 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 360 mg/m3, short term exposure limit 1440 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 100 ppm (360 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 100 ppm (360 mg/m3), short term exposure limit 125 ppm (450 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 100 ppm (360 mg/m3);
short term exposure limit 125 ppm (450 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 360 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 100 ppm (361 mg/m3);
short term exposure limit 125 ppm (452 mg/m3), JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (360 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (360 mg/m3);
KZG- week 200 ppm (720 mg/m3),DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (360 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (366 mg/m3);
short term exposure limit 125 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 100 ppm;
short term exposure limit 125 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 100 ppm;
short term exposure limit 125 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOAMYL ALCOHOL, primary-air time-weighted average 100 ppm;
short term exposure limit 125 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 40380;
Number of Industries 16;
Total Number of Facilities 2,530;
Number of Occupations 18;
Total Number of Employees Exposed 24,606
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 40380;
Number of Industries 43;
Total Number of Facilities 3,803;
Number of Occupations 49;
Total Number of Employees Exposed 65,499;
Total Number of Female Employees Exposed 22,006


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SAMJAF South African Medical Journal. (Medical Assoc. of South Africa, Secy., P.O. Box 643, Cape Town, S. Africa) V.6- 1932-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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