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Bromine

RTECS #: EF9100000

CAS #: 7726-95-6


UPDATE: May 2009 MW: 159.82 MF: Br2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Brom (German)
  2. Brome (French)
  3. Bromine (ACGIH:OSHA)
  1. Bromo (Italian)
  2. Broom (Dutch)
  3. Dibromine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 1,200 mg/m3 N/R VCVN5* -,389,1989
inhalation
cat
lowest published lethal concentration: 150 mg/m3/7 hour Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea
VCVN5* -,389,1989
inhalation
guinea pig
lowest published lethal concentration: 1,200 mg/m3 N/R VCVN5* -,389,1989
inhalation
guinea pig
lowest published lethal concentration: 150 mg/m3/7 hour Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea
VCVN5* -,389,1989
inhalation
human
lowest published lethal concentration: 1,000 ppm N/R 34ZIAG -,645,1969
inhalation
human
lowest published toxic concentration: 13 mg/m3 Lung, Thorax, or Respiration: Cough VCVN5* -,390,1989
inhalation
human
lowest published toxic concentration: 11 mg/m3 Lung, Thorax, or Respiration: Respiratory depression VCVN5* -,390,1989
inhalation
human
lowest published lethal concentration: 220 mg/m3 N/R VCVN5* -,390,1989
inhalation
mammal (species unspecified)
lowest published toxic concentration: 50 mg/m3 Cardiac: Other changes

Endocrine: Other changes
VCVN5* -,389,1989
inhalation
mammal (species unspecified)
lowest published toxic concentration: 100 mg/m3 Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) VCVN5* -,389,1989
inhalation
mouse
lethal concentration (50 percent kill): 750 ppm/9 minute N/R AIHAAP 39,129,1978
inhalation
mouse
lethal concentration (50 percent kill): 2,900 mg/m3 N/R VCVN5* -,389,1989
inhalation
rat
lethal concentration (50 percent kill): 2,700 mg/m3 Lung, Thorax, or Respiration: Other changes GTPZAB 20(3),36,1976
inhalation
rat
lethal concentration (50 percent kill): 2,700 mg/m3 N/R VCVN5* -,389,1989
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour Olfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Respiratory depression
VCVN5* -,389,1989
inhalation
rat
lowest published toxic concentration: 10 mg/m3/4 hour Behavioral: Alteration of classical conditioning TPKVAL 14,63,1975
inhalation
rat
lowest published toxic concentration: 500 mg/m3/4 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi TPKVAL 14,63,1975
inhalation
rat
lowest published toxic concentration: 100 mg/m3/4 hour Lung, Thorax, or Respiration: Other changes TPKVAL 14,63,1975
inhalation
rat
lowest published toxic concentration: 200 mg/m3/4 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 14,63,1975
inhalation
rabbit
lowest published lethal concentration: 180 ppm/6.5 hour N/R HBTXAC 1,324,1955
inhalation
rabbit
lowest published lethal concentration: 1,200 mg/m3 N/R VCVN5* -,389,1989
inhalation
rabbit
lowest published lethal concentration: 150 mg/m3/7 hour Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea
VCVN5* -,389,1989
oral
guinea pig
lethal dose (50 percent kill): 5,500 mg/kg N/R VCVN5* -,389,1989
oral
human
lowest published lethal dose: 14 mg/kg N/R 34ZIAG -,645,1969
oral
mammal (species unspecified)
lethal dose (50 percent kill): 440 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse
lethal dose (50 percent kill): 3,100 mg/kg N/R VCVN5* -,389,1989
oral
rat
lethal dose (50 percent kill): 1,700 mg/kg N/R VCVN5* -,389,1989
oral
rabbit
lethal dose (50 percent kill): 2,500 mg/kg N/R VCVN5* -,389,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,400 g/m3/17 week- intermittent Lung, Thorax, or Respiration: Respiratory depression

Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight
GTPZAB 20(3),36,1976
inhalation
rat
lowest published toxic concentration: 12.4 mg/m3/24 hour/17 week- continuous Cardiac: Other changes

Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,390,1989
inhalation
rat
lowest published toxic concentration: 1.4 mg/m3/24 hour/17 week- continuous Olfaction: Other olfaction effects VCVN5* -,390,1989
inhalation
rabbit
lowest published toxic concentration: 12.4 mg/m3/24 hour/17 week- continuous Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVN5* -,390,1989
inhalation
rabbit
lowest published toxic concentration: 1.4 mg/m3/24 hour/17 week- continuous Olfaction: Other olfaction effects VCVN5* -,390,1989
oral
rat
lowest published toxic dose: 3,094 mg/kg/13 week- intermittent Endocrine: Hyperglycemia

Skin and Appendages: Other: Hair

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
VCVN5* -,390,1989
unreported route
rat
lowest published toxic dose: 3,375 mg/kg/15 day- intermittent Endocrine: Estrogenic VCVN5* -,390,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm;short term exposure limit 0.2 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
CLCHAU 19,361,1973
TOXICOLOGY REVIEW
ENTOX* -,342,2005
TOXICOLOGY REVIEW
HUTOX* -,661,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,298,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.7 mg/m3) DTLVS* 3,27,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.7 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.7 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.7 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.7 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (0.7 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.66 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.67 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.2 ppm (1.3 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.7 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 0.7 mg/m3 (0.1 ppm), FEB 2006
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.7 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 0.1 ppm (0.7 mg/m3), FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.7 mg/m3, short term exposure limit 0.7 mg/m3, Skin, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 0.1 ppm (0.7 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (0.65 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (0.7 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 ppm (0.7 mg/m3);
short term exposure limit 0.3 ppm (2 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.7 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.66 mg/m3);
short term exposure limit 0.3 ppm (2 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.7 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.7 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.7 mg/m3, MAC(short term exposure limit) 2 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 ppm (0.7 mg/m3);
short term exposure limit 0.3 ppm (2 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.7 mg/m3);
KZG- week 0.1 ppm (0.7 mg/m3),DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.7 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.66 mg/m3);
short term exposure limit 0.3 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm;
short term exposure limit 0.2 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm;
short term exposure limit 0.2 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BROMINE-air 10 hour time-weighted average 0.1 ppm;
short term exposure limit 0.3 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 13100;
Number of Industries 17;
Total Number of Facilities 583;
Number of Occupations 16;
Total Number of Employees Exposed 23,977
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 13100;
Number of Industries 40;
Total Number of Facilities 1,679;
Number of Occupations 55;
Total Number of Employees Exposed 62,214;
Total Number of Female Employees Exposed 10,780


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Bromine and chlorine, 6011
OSHA ANALYTICAL METHOD #ID-108


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
HUTOX*
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

RTECS Compound Description:
   Human Data

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