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Boric acid, disodium salt

RTECS #: ED4588000

CAS #: 1330-43-4


UPDATE: May 2009 MW: 201.22 MF: B4O72Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Anhydrous borax
  2. Borates, tetra, sodium salt, anhydrous (ACGIH)
  3. Borates, tetra, sodium salts (anhydrous)
  4. Borax glass
  5. Disodium tetraborate
  6. FR 28
  1. Fused borax
  2. Rasorite 65
  3. Sodium biborate
  4. Sodium boron oxide
  5. Sodium tetraborate
  6. Sodium tetraborate (Na2B4O7)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 16,750 g/kg (30 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
EVHPAZ 13,59,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 2,817 mg/kg N/R VCVN1* -,193,1988
oral
mouse
lethal dose (50 percent kill): 1,060 mg/kg N/R VCVN1* -,193,1988
oral
rat
lethal dose (50 percent kill): 1,200 mg/kg N/R VCVN1* -,193,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 26 gm/kg/14 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Xanthine, purine or nucleotides including urate
TOLED5 10,219,1982
oral
rat
lowest published toxic dose: 1,312.5 mg/kg/70 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVN1* -,195,1988
oral
rat
lowest published toxic dose: 283.5 mg/kg/70 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
VCVN1* -,195,1988
oral
rabbit
lowest published toxic dose: 22,680 mg/kg/12 week- intermittent Blood: Luekopenia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count
VCVN1* -,195,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 mg/m3;short term exposure limit 6 mg/m3 (inhalable) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,91,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 mg/m3, short term exposure limit 6 mg/m3, MAR2002
Occupational Exposure Limit - FRANCE VME 1 mg/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 1 mg/m3, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: B0085;
Number of Industries 34;
Total Number of Facilities 1,170;
Number of Occupations 27;
Total Number of Employees Exposed 5,513
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3899;
Number of Industries 1;
Total Number of Facilities 5;
Number of Occupations 1;
Total Number of Employees Exposed 101
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3899;
Number of Industries 87;
Total Number of Facilities 6,225;
Number of Occupations 57;
Total Number of Employees Exposed 78,116;
Total Number of Female Employees Exposed 15,080


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as component in cleaning agents, wood preservatives and fungicides
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
VCVN1* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov I-IV groopp" (Hazardous substances. Inornanic substances containing I-IV group elements), Filov V.A., Chimia, 1988.

Used as component in cleaning agents, wood preservatives and fungicides

RTECS Compound Description:
   Reproductive Effector

ALT CAS #: 1332-28-1
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