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Biphenyl, mixed with biphenyl oxide (3:7)

RTECS #: DV1500000

CAS #: 8004-13-5


UPDATE: August 2006 MW: 324.44 MF: C12H10OC12H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,1' - Biphenyl, mixt. with 1,1' - oxybis (benzene)
  2. Biphenyl - diphenyl ether mixture
  3. Dinil
  4. Dinyl
  5. Diphenyl mixed with diphenyl oxide
  1. Diphyl
  2. Dowtherm
  3. Dowtherm A
  4. Phenyl ether - biphenyl mixture (OSHA)
  5. Phenyl ether - diphenyl mixture


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 28ZPAK -,271,1972
skin
rabbit
500 mg/24 hour mild 28ZPAK -,271,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 3 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
28ZRAQ -,204,1960
inhalation
human
lowest published toxic concentration: 26.8 mg/m3 Eye: Conjunctiva irritation

Behavioral: Headache

Lung, Thorax, or Respiration: Cough
VCVGK* -,308,1984
oral
guinea pig
lethal dose (50 percent kill): 3 gm/kg N/R 85GMAT -,61,1982
oral
mouse
lethal dose (50 percent kill): 3,200 mg/kg N/R VCVGK* -,308,1984
oral
rat
lethal dose (50 percent kill): 2,460 mg/kg N/R 28ZPAK -,271,1972
oral
rabbit
lethal dose (50 percent kill): 4,200 mg/kg N/R VCVGK* -,308,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 200 g/m3/24 hour/70 day- continuous Behavioral: Muscle contraction or spasticity

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
GISAAA 26(5),3,1961
inhalation
rat
lowest published toxic concentration: 20 mg/m3/4 hour/122 day- intermittent Lung, Thorax, or Respiration: Emphysema

Blood: Change in clotting factors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,308,1994
inhalation
rat
lowest published toxic concentration: 10 mg/m3/70 day- continuous Behavioral: Muscle weakness

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
VCVGK* -,308,1994
oral
rat
lowest published toxic dose: 130 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ATORAI -,1,1948


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ATORAI -,-,1948


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (7 mg/m3) (vapor) DTLVS* 3,206,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 ppm (7 mg/m3), vapor CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 ppm (7 mg/m3), vapor CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 ppm (7 mg/m3), vapor CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 ppm (7 mg/m3), vapor CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - MEXICO time-weighted average 1 ppm (7 mg/m3) (vapor), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 7 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (7 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL ETHER-BIPHENYL MIXTURE, vapor-air 10 hour time-weighted average 1 ppm NIOSH* DHHS#92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phenyl ether-diphenyl mixture, 2013


REFERENCES:

CODEN
REFERENCE

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
28ZRAQ "Toxicology and Biochemistry of Aromatic Hydrocarbons," Gerarde, H., New York, Elsevier, 1960
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
ATORAI A.P.I. Toxicological Review. (American Petroleum Institute, 2101 L St., NW, Washington, DC 20037)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Human Data
   Primary Irritant

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