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Benzene, o - dichloro -

RTECS #: CZ4500000

CAS #: 95-50-1


UPDATE: May 2009 MW: 147.00 MF: C6H4Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,2 - Dichlorobenzene
  2. Benzene, 1,2 - dichloro -
  3. Chloroben
  4. Dilatin DB
  5. Dizene
  6. Dowtherm E
  7. NCI - C54944
  8. Orthodichlorobenzene
  1. Orthodichlorobenzol
  2. Special termite fluid
  3. Termitkil
  4. o - Dichlor benzol
  5. o - Dichlorbenzene
  6. o - Dichlorobenzene
  7. o - Dichlorobenzene (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/30S rinse mild AMIHAB 17,180,1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms mouse lymphocyte 6,500 g/L (+enzymatic activation step) SCIEAS 236,933,1987
micronucleus test intraperitoneal
mouse
187 mg/kg/24 hour MUTAEX 2,111,1987
gene conversion and mitotic recombination Saccharomyes cerevisiae 1 mmol/L MUREAV 413,205,1998
sister chromatid exchange hamster ovary 59 mg/L SCIEAS 236,933,1987
specific locus test inhalation
mouse
68 mol/L MUREAV 608,29,2006
sperm morphology intraperitoneal
rat
250 mg/kg JACTDZ 4(2),224,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 200 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FAATDF 5,190,1985
inhalation
rat
lowest published toxic concentration: 500 ppm/6 hour (6-15 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** OTS0535228
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JACTDZ 4(1),224,1985


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 30,900 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Adrenal cortex tumors
NTIS** PB86-144888/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 800 ppm/24 hour Liver: Hepatitis (hepatocellular necrosis), diffuse JPBAA7 44,281,1937
inhalation
rat
lowest published lethal concentration: 821 ppm/7 hour Behavioral: General anesthetic

Liver: Hepatitis (hepatocellular necrosis), zonal

Eye: Lacrimation
AMIHAB 17,180,1958
inhalation
rat
lethal concentration (50 percent kill): 8,150 mg/m3/4 hour Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: General anesthetic

Behavioral: Muscle contraction or spasticity
VCVGK* -,24,1984
intraperitoneal
mouse
lethal dose (50 percent kill): 1,228 mg/kg N/R MUTAEX 2,111,1987
intraperitoneal
rat
lethal dose (50 percent kill): 840 mg/kg N/R MEPAAX 20,519,1969
intraperitoneal
rat
lowest published toxic dose: 735 mg/kg N/R VCVGK* -,24,1984
intraperitoneal
rat
lowest published toxic dose: 1 mg/kg Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 111,69,1991
intraperitoneal
rat
lowest published toxic dose: 735 mg/kg Gastrointestinal: Changes in structure or function of exocrine pancreas

Gastrointestinal: Other changes
VCVGK* -,24,1984
intravenous
mouse
lowest published lethal dose: 400 mg/kg N/R JPBAA7 44,281,1937
intravenous
rabbit
lowest published lethal dose: 250 mg/kg N/R JPBAA7 44,281,1937
oral
guinea pig
lowest published lethal dose: 2 gm/kg N/R 14CYAT 2,1336,1963
oral
mouse
lethal dose (50 percent kill): 4,386 mg/kg N/R YKYUA6 32,471,1981
oral
rat
lethal dose (50 percent kill): 500 mg/kg N/R WRPCA2 9,119,1970
oral
rabbit
lethal dose (50 percent kill): 500 mg/kg N/R 85ARAE 3,32,1976/1977
subcutaneous
rat
lethal dose (50 percent kill): 5 gm/kg N/R TSCAT* OTS 205976
skin
rabbit
lethal dose (50 percent kill): >10 gm/kg N/R NTIS** OTS0521597


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 290 mg/m3/7 hour/26 week- intermittent Liver: Other changes VCVGK* -,24,1994
inhalation
rat
lowest published toxic concentration: 200 mg/m3/4 hour/17 week- intermittent Brain and Coverings: Other degenerative changes

Blood: Changes in cell count (unspecified)
VCVGK* -,24,1994
oral
mouse
lowest published toxic dose: 7 gm/kg/14 day- intermittent Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-255,1985
oral
mouse
lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight
NTPTR* NTP-TR-255,1985
oral
rat
lowest published toxic dose: 27,300 g/kg/39 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Angranulocytosis

Blood: Changes in erythrocyte (RBC) count
GISAAA 33(10),15,1968
oral
rat
lowest published toxic dose: 3 gm/kg/10 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in leukocyte (WBC) count
DCTODJ 14,83,1991
oral
rat
lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count
NTPTR* NTP-TR-255,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm;short term exposure limit 50 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 7,231,1974
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 7,231,1974
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 29,213,1982
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 29,213,1982
International Agency for Research on Cancer (IARC) Cancer Review Animal No Cancer Evidence IMEMDT 73,223,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,223,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 73,223,1999
TOXICOLOGY REVIEW
ENTOX* -,5,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,249,1998
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 50 ppm (300 mg/m3) DTLVS* 3,76,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 50 ppm (300 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 50 ppm (300 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 50 ppm (300 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 50 ppm (300 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (150 mg/m3), short term exposure limit 50 ppm (301 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 20 ppm (122 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 50 ppm (306 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 20 ppm (122 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 122 mg/m3 (20 ppm);
short term exposure limit 306 mg/m3 (skin), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (300 mg/m3), short term exposure limit 75 ppm (450 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 20 ppm (122 mg/m3), VLE 50 ppm (306 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 61 mg/m3 (10 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 122 mg/m3, short term exposure limit 306 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 25 ppm (150 mg/m3), APR2007
Occupational Exposure Limit - KOREA ceiling concentration 50 ppm (300 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 50 ppm (300 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 122 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 50 ppm (301 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (150 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 20 mg/m3, MAC(CEILING) 300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 50 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (150 mg/m3), ceiling concentration 50 ppm (300 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (61 mg/m3),KZG- week 20 ppm (122 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 50 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (153 mg/m3);
short term exposure limit 50 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO o-DICHLOROBENZENE-air ceiling concentration 50 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24003;
Number of Industries 83;
Total Number of Facilities 8,838;
Number of Occupations 69;
Total Number of Employees Exposed 72,149
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24003;
Number of Industries 59;
Total Number of Facilities 10,577;
Number of Occupations 59;
Total Number of Employees Exposed 92,246;
Total Number of Female Employees Exposed 12,686


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as an insecticide and pesticide, and an intermediate for agricultural chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE

14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JPBAA7 Journal of Pathology and Bacteriology. (London, UK) V.1-96, 1892-1968. For publisher information, see JPTLAS.
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as an insecticide and pesticide, and an intermediate for agricultural chemicals

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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