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Benzene, chloro -

RTECS #: CZ0175000

CAS #: 108-90-7


UPDATE: May 2009 MW: 112.56 MF: C6H5Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Benzene chloride
  2. Chloorbenzeen (Dutch)
  3. Chlorbenzene
  4. Chlorbenzol
  5. Chlorobenzen (Polish)
  6. Chlorobenzene
  7. Chlorobenzene (ACGIH:OSHA)
  8. Chlorobenzenu (Czech)
  9. Clorobenzene (Italian)
  10. MCB
  1. Monochloorbenzeen (Dutch)
  2. Monochlorbenzene
  3. Monochlorbenzol (German)
  4. Monochlorobenzene
  5. Monochlorobenzene (OSHA)
  6. Monoclorobenzene (Italian)
  7. NCI - C54886
  8. Phenyl chloride
  9. Tetrosin SP


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis intraperitoneal
mouse
1 gm/kg EMMUEG 25,302,1995
cytogenetic analysis inhalation
rat
500 g/L/275 day- intermittent VCVGK* -,20,1994
mutation in microorganisms mouse lymphocyte 70 mg/L (+enzymatic activation step) EMMUEG 12,85,1988
micronucleus test intraperitoneal
mouse
225 mg/kg/24 hour MUTAEX 2,111,1987
gene conversion and mitotic recombination Saccharomyes cerevisiae 1,000 ppm NTIS** PB84-138973
mutation in mammalian somatic cells mouse lymphocyte 100 mg/L EMMUEG 12,85,1988
sister chromatid exchange hamster ovary 300 mg/L SCIEAS 236,933,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 75 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 76,365,1984
inhalation
rat
lowest published toxic concentration: 210 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Hepatobiliary system TXAPA9 76,365,1984
inhalation
rabbit
lowest published toxic concentration: 590 ppm/6 hour (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXAPA9 76,365,1984
inhalation
rabbit
lowest published toxic concentration: 10 ppm/6 hour (6-18 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 76,365,1984


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 61,800 mg/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Blood: Tumors
NTPTR* NTP-TR-261,1985
oral
rat
lowest published toxic dose: 61,800 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTIS** PB86-144714/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 10 gm/m3 N/R GTPZAB 32(10),25,1988
inhalation
mouse
lowest published lethal concentration: 15 gm/m3 N/R GISAAA 20(8),19,1955
inhalation
mouse
lowest published toxic concentration: 700 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
mouse
lethal concentration (50 percent kill): 4,300 ppm/2 hour N/R ENTOX* -,556,2005
inhalation
rat
lethal concentration (50 percent kill): 2,965 ppm N/R NTIS** OTS0521601
intraperitoneal
guinea pig
lowest published lethal dose: 4,100 mg/kg Behavioral: Muscle weakness

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes
RMSRA6 16,449,1896
intraperitoneal
mouse
lethal dose (50 percent kill): 515 mg/kg N/R PHMCAA 10,172,1968
intraperitoneal
rat
lethal dose (50 percent kill): 1,655 mg/kg N/R FAATDF 5,105,1985
intraperitoneal
rat
lowest published toxic dose: 2 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXAPA9 111,69,1991
intraperitoneal
rat
lowest published toxic dose: 1 mg/kg Liver: Changes in liver weight TXAPA9 111,69,1991
oral
chicken
lowest published toxic dose: 800 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
VCVGK* -,19,1984
oral
guinea pig
lethal dose (50 percent kill): 2,250 mg/kg N/R 85GMAT -,34,1982
oral
mammal (species unspecified)
lethal dose (50 percent kill): 2,300 mg/kg N/R GTPZAB 32(10),25,1988
oral
mouse
lethal dose (50 percent kill): 2,300 mg/kg N/R ENTOX* -,556,2005
oral
rat
lethal dose (50 percent kill): 1,110 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Ataxia
SRTCAC 36(1-4),10,1989
oral
rat
lethal dose (50 percent kill): 2,290 mg/kg N/R ENTOX* -,556,2005
oral
rabbit
lethal dose (50 percent kill): 2,250 mg/kg N/R 38MKAJ 2B,3603,1981
skin
guinea pig
lethal dose : >11 gm/kg N/R 85INA8 6,271,1991
skin
rabbit
lethal dose : >2,200 mg/kg N/R NTIS** AD-A180-198
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 2,300 mg/kg N/R GISAAA 51(5),61,1986
unreported route
rat
lowest published lethal dose: 4,000 mg/kg Liver: Other changes VCVGK* -,19,1984
unreported route
rat
lethal dose (50 percent kill): 2,950 mg/kg Liver: Other changes VCVGK* -,19,1984
unreported route
rat
lowest published toxic dose: 0.26 mg/kg Behavioral: Food intake (animal)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
VCVGK* -,19,1984
unreported route
rabbit
lethal dose (50 percent kill): 2,830 mg/kg Liver: Other changes VCVGK* -,19,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1 mg/m3/60 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
GISAAA 30(3),8,1965
inhalation
rat
lowest published toxic concentration: 250 ppm/7 hour/24 week- intermittent Liver: Changes in liver weight

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTIS** OTS0555046
inhalation
rabbit
lowest published toxic concentration: 250 ppm/7 hour/24 week- intermittent Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTIS** OTS0555046
inhalation
rabbit
lowest published toxic concentration: 2.5 mg/m3/3 week- intermittent Liver: Fatty liver degeneration

Blood: Changes in cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,19,1994
inhalation
rabbit
lowest published toxic concentration: 5 mg/m3/213 day- intermittent Endocrine: Adrenal cortex hyperplasia VCVGK* -,20,1994
oral
dog
lowest published toxic dose: 17,712 mg/kg/93 day- intermittent Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 19,393,1971
oral
guinea pig
lowest published toxic dose: 441 mg/kg/63 week- intermittent Gastrointestinal: Gastritis

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
GISAAA 20(7),7,1955
oral
mouse
lowest published toxic dose: 16,250 mg/kg/13 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Other changes in urine composition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTEHD6 15,745,1985
oral
mouse
lowest published toxic dose: 22,750 mg/kg/13 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,20,1994
oral
rat
lowest published toxic dose: 14 gm/kg/14 day- intermittent Behavioral: Somnolence (general depressed activity)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTEHD6 15,745,1985
oral
rat
lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTEHD6 15,745,1985
oral
rat
lowest published toxic dose: 27,300 g/kg/39 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Eosinophilia

Blood: Changes in erythrocyte (RBC) count
GISAAA 33(10),15,1968
oral
rat
lowest published toxic dose: 22,750 mg/kg/13 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,20,1994
oral
rat
lowest published toxic dose: 1,170 mg/kg/31 week- intermittent Gastrointestinal: Other changes

Gastrointestinal: Tumors
VCVGK* -,20,1994
oral
rabbit
lowest published toxic dose: 441 mg/kg/63 week- intermittent Gastrointestinal: Gastritis

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
GISAAA 20(7),7,1955
unreported route
mouse
lowest published toxic dose: 7,000 mg/kg/2 week- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,19,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
TOLED5 138,1,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
ENTOX* -,556,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
HUTOX* -,683,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 75 ppm (350 mg/m3) DTLVS* 3,49,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 75 ppm (350 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 75 ppm (350 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 75 ppm (350 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 75 ppm (350 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 1 ppm, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (46 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (23 mg/m3), short term exposure limit 15 ppm (70 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (46 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 23 mg/m3 (5 ppm);
short term exposure limit 70 mg/m3 (15 ppm), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (230 mg/m3), short term exposure limit 75 ppm (345 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (47 mg/m3), VLE 20 ppm (94 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 47 mg/m3 (10 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 47 mg/m3, short term exposure limit 94 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 10 ppm (46 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 75 ppm (350 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 75 ppm (350 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 46 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (46 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 50 mg/m3, short term exposure limit 150 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 50 mg/m3, short term exposure limit 100 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 5 ppm (23 mg/m3);
short term exposure limit 15 ppm (70 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (46 mg/m3);
KZG- week 20 ppm (92 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 75 ppm (350 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm;
short term exposure limit 3 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18190;
Number of Industries 36;
Total Number of Facilities 1,965;
Number of Occupations 46;
Total Number of Employees Exposed 46,734
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 18190;
Number of Industries 24;
Total Number of Facilities 912;
Number of Occupations 35;
Total Number of Employees Exposed 18,050;
Total Number of Female Employees Exposed 3,881


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180505/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a chemical intermediate, solvent and emulsifier
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-261,1985
NCI Carcinogenesis Studies (gavage);equivocal evidence:rat
NCI Carcinogenesis Studies (gavage);no evidence:mouse


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HUTOX*
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959-
RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a chemical intermediate, solvent and emulsifier

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

Click Here for Additional Information about RTECS

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