Anisole, 2,4-diamino-

RTECS #

BZ8580500

CAS #

615-05-4
See: NMAM or OSHA Methods

Updated

July 2013

Molecular Weight

138.19

Molecular Formula

C₇H₁₀N₂O

Synonyms

1,3-Benzenediamine, 4-methoxy- (9CI)
2,4-Diamineanisole
2,4-Diamino-1-methoxybenzene
2,4-Diaminoanisole
2,4-Diaminoanisole base
4-Methoxy-1,3-benzenediamine
4-Methoxy-m-phenylenediamine
C.I. 76050
C.I. Oxidation Base 12
Furro L
m-Diaminoanisole 1,3-diamino-4-methoxybenzene
m-Phenylenediamine, 4-methoxy- (8CI)
Pelagol DA
Pelagol Grey L
Pelagol L
p-Methoxy-m-phenylenediamine

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	12500 µg/24H	mild	FCTXAV 15,607,1977

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA adduct	liver/rat	500 µmol/L	CBINA8 31,35,1980
DNA Damage	fibroblast/human	50 µmol/L	MUREAV 127,107,1984
DNA Damage	intraperitoneal/rat	660 µmol/kg	CRNGDP 2,1317,1981
mutation in mammalian somatic cells	lymphocyte/mouse	18750 gm/L	JEPTDQ 1(1),87,1977
mutation in microorganisms	/Salmonella typhimurium	1 nmol/plate/20M	EMMUEG 38,268,2001
mutation in microorganisms	/Salmonella typhimurium	50 µg/plate (-enzymatic activation step)	CRNGDP 7,899,1986
sister chromatid exchange	intraperitoneal/mouse	12 mg/kg	MUREAV 108,225,1983

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
subcutaneous/mammal (species unspecified)	65100 µg/kg (10D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	JIDOAA 35,387,1986

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	lethal dose (50 percent kill): 116 mg/kg	Kidney, Ureter, and Bladder: Urine volume increased Kidney, Ureter, and Bladder: Other changes in urine composition	BCPCA6 30,2715,1981
oral/rat	lethal dose (50 percent kill): 460 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Skin and Appendages: Other: Hair	FCTXAV 15,607,1977

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 3780 mg/kg/6W- continuous	Endocrine: Evidence of thyroid hypofunction Endocrine: Other changes	BMERE* 12,77,1991

Reviews

Organization	Standard	Reference
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 79,-,2000
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 79,-,2000
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 79,-,2000
TOXICOLOGY REVIEW		MUREAV 567,347,2004
TOXICOLOGY REVIEW		IMEMDT 79,621,
TOXICOLOGY REVIEW		TXAPA9 243,239,2010

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-JAPAN	2B carc, MAY2012
Occupational Exposure Limit-SWEDEN	Group B Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLAND	carc 2, JAN2011

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,4-DIAMINOANISOLE-air	Carcinogen lowest feasible conc.	NIOSH* DHHS #92-100,1992

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 19, 1978

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health