Adiponitrile
RTECS #
AV2625000
CAS #
Updated
September 2013
Molecular Weight
108.16
Molecular Formula
C6H8N2
Synonyms
1,4-Dicyanobutane
Adipic acid dinitrile
Adipic acid nitrile
Adipinsaeuredinitril (German)
Adiponitril (ACGIH)
Hexanedinitrile
Hexanedioic acid, dinitrile
Nitrile adipico (Italian)
Tetramethylene cyanide
Adipic acid dinitrile
Adipic acid nitrile
Adipinsaeuredinitril (German)
Adiponitril (ACGIH)
Hexanedinitrile
Hexanedioic acid, dinitrile
Nitrile adipico (Italian)
Tetramethylene cyanide
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /rabbit | 0.1 mL | mild | HPV215 -,-,2001 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 100 mg/m3 (22D prior to copulation) | Reproductive: Other effects on female | HPV215 -,-,2001 |
| oral/rat | 1120 mg/kg (6-19D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | FAATDF 7,33,1986 |
| oral/rat | 1400 mg/kg (6-19D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | DCTODJ 27,123,2004 |
| oral/rat | 1120 mg/kg (6-19D pregnant) | Reproductive: Other effects on female | HPV215 -,-,2001 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lethal concentration (50 percent kill): 1710 mg/m3/4H | Ear: Change in acuity Lung, Thorax, or Respiration: Other changes | TOXID9 1,76,1981 |
| inhalation/rat | lethal concentration (50 percent kill): 1.71 gm/m3/4H | DCTODJ 27,123,2004 | |
| inhalation/rat | Lowest published lethal concentration: 0.83 gm/m3/4H | Eye: Conjunctiva irritation Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression | DCTODJ 27,123,2004 |
| inhalation/rat | Lowest published lethal concentration: 0.83 gm/m3/4H | Gastrointestinal: Changes in structure or function of salivary glands | DCTODJ 27,123,2004 |
| inhalation/rat | lethal concentration (50 percent kill): 1710 mg/m3/4H | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Changes in structure or function of salivary glands | HPV215 -,-,2001 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 40 mg/kg | NTIS** AD691-490 | |
| oral/cat | lethal dose (50 percent kill): 25 mg/kg | ZAARAM 19,225,1969 | |
| oral/mouse | lethal dose (50 percent kill): 172 mg/kg | ENTOX* -,49,2005 | |
| oral/rabbit | lethal dose (50 percent kill): 22 mg/kg | ENTOX* -,49,2005 | |
| oral/rat | lethal dose (50 percent kill): 100 mg/kg | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Nausea or vomiting Nutritional and Gross Metabolic: Weight loss or decreased weight gain | DCTODJ 27,123,2004 |
| oral/rat | lethal dose (50 percent kill): 155 mg/kg | ENTOX* -,49,2005 | |
| oral/rat | lethal dose (50 percent kill): 138 mg/kg | Behavioral: Somnolence (general depressed activity) Gastrointestinal: Hypermotility, diarrhea Nutritional and Gross Metabolic: Weight loss or decreased weight gain | HPV215 -,-,2001 |
| skin/rabbit | lethal dose (50 percent kill): 2134 mg/kg | Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression Gastrointestinal: Hypermotility, diarrhea | HPV215 -,-,2001 |
| skin/rabbit | lowest published lethal dose: 1 mg/kg | ZAARAM 19,225,1969 | |
| skin/rabbit | lethal dose (50 percent kill): 2134 mg/kg/24H | DCTODJ 27,123,2004 | |
| skin/rabbit | lowest published lethal dose: 1260 mg/kg/24H | Behavioral: Sleep Behavioral: Somnolence (general depressed activity) Behavioral: Food intake (animal) | DCTODJ 27,123,2004 |
| skin/rabbit | lowest published lethal dose: 1260 mg/kg/24H | Gastrointestinal: Nausea or vomiting | DCTODJ 27,123,2004 |
| subcutaneous/guinea pig | lethal dose (50 percent kill): 50 mg/kg | ENTOX* -,49,2005 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 500 mg/m3/4W- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Other changes | DCTODJ 27,123,2004 |
| inhalation/rat | lowest published toxic concentration: 500 mg/m3/4W- intermittent | Blood: Changes in spleen | DCTODJ 27,123,2004 |
| inhalation/rat | lowest published toxic concentration: 100 mg/m3/22D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | DCTODJ 27,123,2004 |
| inhalation/rat | lowest published toxic concentration: 493 mg/m3/6H/4W- intermittent | Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JTEHD6 30,199,1990 |
| inhalation/rat | lowest published toxic concentration: 99 mg/m3/6H/13W- intermittent | Blood: Pigmented or nucleated red blood cells Blood: Changes in other cell count (unspecified) Blood: Changes in erythrocyte (RBC) count | JTEHD6 30,199,1990 |
| inhalation/rat | lowest published toxic concentration: 3028 µg/m3/5H/26W- intermittent | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GTPZAB 25(9),64,1981 |
| inhalation/rat | lowest published toxic concentration: 30 mg/m3/2W- intermittent | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | DCTODJ 27,123,2004 |
| inhalation/rat | lowest published toxic concentration: 100 mg/m3/2W- intermittent | Blood: Other changes | DCTODJ 27,123,2004 |
| inhalation/rat | lowest published toxic concentration: 300 mg/m3/2W- intermittent | Blood: Changes in erythrocyte (RBC) count | DCTODJ 27,123,2004 |
| inhalation/rat | lowest published toxic concentration: 99 mg/m3/13W- intermittent | Blood: Other changes Blood: Changes in erythrocyte (RBC) count | HPV215 -,-,2001 |
| oral/Dog | lowest published toxic dose: 350 mg/kg/244D- continuous | Gastrointestinal: Nausea or vomiting | DCTODJ 27,123,2004 |
| oral/rat | lowest published toxic dose: 1120 mg/kg/14D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | DCTODJ 27,123,2004 |
| oral/rat | lowest published toxic dose: 2920 mg/kg/2Y- intermittent | Endocrine: Adrenal cortex hypoplasia Endocrine: Changes in adrenal weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV215 -,-,2001 |
| oral/rat | lowest published toxic dose: 1120 mg/kg/14D- intermittent | Cardiac: Pericarditis Lung, Thorax, or Respiration: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | HPV215 -,-,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 2 ppm (skin) | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | DCTODJ 27,123,2004 | |
| TOXICOLOGY REVIEW | ENTOX* -,49,2005 | |
| TOXICOLOGY REVIEW | FCTOD7 47,1287,2009 |
Standards and Regulations
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ADIPONITRILE-air | 10H time-weighted average 4 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code X4253; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 2; Total Number of Employees Exposed 478; Total Number of Female Employees Exposed 41 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health