CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Acrylic acid, ethyl ester

RTECS #: AT0700000

CAS #: 140-88-5


UPDATE: May 2009 MW: 100.13 MF: C5H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2 - Propanoic acid, ethyl ester
  2. 2 - Propenoic acid, ethyl ester
  3. Acrylate d'ethyle (French)
  4. Acrylsaeureaethylester (German)
  5. Aethylacrylat (German)
  6. Akrylanem etylu (Polish)
  7. Carboset 511
  8. Ethoxycarbonylethylene
  9. Ethyl 2 - propenoate
  10. Ethyl acrylate
  1. Ethyl acrylate (ACGIH:OSHA)
  2. Ethyl propenoate
  3. Ethylacrylaat (Dutch)
  4. Ethylakrylat (Czech)
  5. Ethylester kyseliny akrylove (Czech)
  6. Etil acrilato (Italian)
  7. Etilacrilatului (Romanian)
  8. NCI - C50384
  9. RCRA waste number U113


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
guinea pig
1,204 ppm/7 hour N/R JIHTAB 31,317,1949
eye
monkey
1,204 ppm/15 hour- intermittent N/R JIHTAB 31,317,1949
eye
rat
1,204 ppm/14 hour- intermittent N/R JIHTAB 31,317,1949
eye
rabbit
45 mg mild UCDS** 12/14/1971
eye
rabbit
1,204 ppm/7 hour mild JIHTAB 31,317,1949
skin
rabbit
500 mg open irritation test mild UCDS** 12/14/1971
skin
rabbit
10 mg/24 hour mild JIHTAB 31,311,1949


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 299 mg/L SCIEAS 236,933,1987
cytogenetic analysis hamster lung 9,800 g/L GMCRDC 27,95,1981
cytogenetic analysis mouse lymphocyte 20 mg/L ENMUDM 8(Suppl 6),4,1986
mutation in microorganisms mouse lymphocyte 20 mg/L (+enzymatic activation step) ENMUDM 8(Suppl 6),4,1986
mutation in microorganisms Salmonella typhimurium 100 g/plate (-enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
micronucleus test intraperitoneal
mouse
225 mg/kg MUREAV 135,189,1984
mutation in mammalian somatic cells mouse lymphocyte 20 mg/L ENMUDM 8(Suppl 6),4,1986
sister chromatid exchange hamster ovary 150 mg/L SCIEAS 236,933,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 200 ppm/6 hour (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOSCF2 48,240,1999
inhalation
rat
lowest published toxic concentration: 200 ppm (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female
TOSCF2 48,240,1999
oral
rat
lowest published toxic dose: 8 gm/kg (0-19 day pregnant) Reproductive: Other effects on female NTIS** OTS0557583


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 103 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTPTR* NTP-TR-259,1986
oral
mouse
lowest published toxic dose: 51,500 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB87-204061/AS
oral
rat
lowest published toxic dose: 51,500 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTPTR* NTP-TR-259,1986
oral
rat
lowest published toxic dose: 51,500 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB87-204061/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 1,204 ppm/7 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cough
JIHTAB 31,317,1949
inhalation
human
lowest published toxic concentration: 50 ppm Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes
34ZIAG -,75,1969
inhalation
monkey
lethal concentration : >75 ppm/6 hour Olfaction: Deviated nasal septum

Olfaction: Ulcerated nasal septum
TOXID9 36(1 Pt2),113,1997
inhalation
mouse
lethal concentration (50 percent kill): 16,200 mg/m3 N/R GTPZAB 23(9),55,1979
inhalation
mouse
lowest published toxic concentration: 200 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
rat
lethal concentration (50 percent kill): 1,414 ppm/4 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0520180
inhalation
rat
lowest published toxic concentration: 4.2 gm/m3/6 hour Liver: Other changes

Endocrine: Hyperglycemia

Biochemical: Metabolism (intermediary): Other
TXCYAC 65,209,1990
inhalation
rat
lowest published toxic concentration: 25 ppm/3 hour Olfaction: Change in olfactory nerve

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 183,23,2002
inhalation
rat
lethal concentration (50 percent kill): 2,180 ppm/4 hour N/R ENTOX* -,279,2005
inhalation
rabbit
lowest published lethal concentration: 1,204 ppm/7 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea
JIHTAB 31,317,1949
intraperitoneal
mouse
lethal dose (50 percent kill): 599 mg/kg N/R JDREAF 51,526,1972
intraperitoneal
rat
lethal dose (50 percent kill): 450 mg/kg N/R AMPMAR 36,58,1975
oral
cat
lethal dose : >800 L/kg Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting
NTIS** OTS0521003
oral
mouse
lethal dose (50 percent kill): 1,799 mg/kg N/R TOLED5 11,125,1982
oral
rat
lethal dose (50 percent kill): 800 mg/kg N/R BCTKAG 12,405,1979
oral
rabbit
lethal dose (50 percent kill): 370 mg/kg Gastrointestinal: Alteration in gastric secretion NTIS** OTS0521003
skin
human
lowest published toxic concentration: 0.1 pph Skin: After topical application: Dermatitis, allergic AJCDE* 13,108,2002
skin
mouse
lethal dose (50 percent kill): 2,997 mg/kg N/R NTIS** OTS0520999
skin
rat
lowest published lethal dose: 1,800 mg/kg N/R PJPPAA 32,223,1980
skin
rat
lethal dose (50 percent kill): 3,049 mg/kg N/R ENTOX* -,279,2005
skin
rabbit
lethal dose (50 percent kill): 500 L/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0520180


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 75 ppm/6 hour/26 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
APTOD9 19,A53,1980
inhalation
mouse
lowest published toxic concentration: 75 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 8,1,1985
inhalation
mouse
lowest published toxic concentration: 75 ppm/6 hour/1 year- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0544830
inhalation
mouse
lowest published toxic concentration: 300 ppm/6 hour/30 day- intermittent Olfaction: Deviated nasal septum

Olfaction: Ulcerated nasal septum

Olfaction: Other olfaction effects
NTIS** OTS0540690
inhalation
rat
lowest published toxic concentration: 75 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 8,1,1985
inhalation
rat
lowest published toxic concentration: 300 ppm/7 hour/30 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 31(6),311,1949
inhalation
rat
lowest published toxic concentration: 75 ppm/6 hour/26 week- intermittent Olfaction: Other olfaction effects NTIS** OTS0520180
oral
mouse
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Gastrointestinal: Other changes NTPTR* NTP-TR-259,1986
oral
rat
lowest published toxic dose: 6,500 mg/kg/13 week- intermittent Gastrointestinal: Other changes NTIS** OTS0540988
oral
rat
lowest published toxic dose: 183 gm/kg/2 year- continuous Behavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 6,29,1964
oral
rat
lowest published toxic dose: 11,200 mg/kg/14 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach NTPTR* NTP-TR-259,1986
oral
rat
lowest published toxic dose: 800 mg/kg/4 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Other changes
TXAPA9 80,323,1985
oral
rat
lowest published toxic dose: 5,600 mg/kg/28 day- continuous Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0533909
skin
human
lowest published toxic concentration: 0.1 pph/48 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,177,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm;short term exposure limit 15 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 39,81,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1447,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,81,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1447,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,1447,1999
TOXICOLOGY REVIEW
EVHPAZ 11,141,1975
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
ENTOX* -,279,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (100 mg/m3) (skin) DTLVS* 3,102,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA ceiling concentration 5 ppm (20 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (20 mg/m3), short term exposure limit 15 ppm (62 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (20 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (40 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 5 ppm (20 mg/m3), Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 21 mg/m3 (5 mL/m3) (skin, sen), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 10 mg/m3, short term exposure limit 10 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 5 ppm (20 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 ppm (20 mg/m3);
short term exposure limit 25 ppm (100 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 20 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 5 ppm (20 mg/m3), sen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 25 ppm (100 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND time-weighted average 20 mg/m3, short term exposure limit 80 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 5 mg/m3, short term exposure limit 15 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 5 ppm (20 mg/m3);
short term exposure limit 10 ppm (40 mg/m3), Skin, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (20 mg/m3),KZG- week 10 ppm (40 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (100 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (21 mg/m3);
short term exposure limit 15 ppm (62 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL ACRYLATE-air Carcinogen (4.0 ppm LOQ) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 31490;
Number of Industries 42;
Total Number of Facilities 3,312;
Number of Occupations 51;
Total Number of Employees Exposed 40,491
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 31490;
Number of Industries 26;
Total Number of Facilities 2,898;
Number of Occupations 42;
Total Number of Employees Exposed 44,604;
Total Number of Female Employees Exposed 7,205


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in emulsion polymers for paints, textiles, adhesives, coatings and binders
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
OSHA ANALYTICAL METHOD #92


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information, see PJPAE3
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in emulsion polymers for paints, textiles, adhesives, coatings and binders

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us