Acrylic acid, ethyl ester
RTECS #
AT0700000
CAS #
Updated
December 2018
Molecular Weight
100.13
Molecular Formula
C5H8O2
Synonyms
2-Propanoic acid, ethyl ester
2-Propenoic acid, ethyl ester
Acrylate d'ethyle (French)
Acrylsaeureaethylester (German)
Aethylacrylat (German)
Akrylanem etylu (Polish)
Carboset 511
Ethoxycarbonylethylene
Ethyl 2-propenoate
Ethyl acrylate
Ethyl acrylate (ACGIH:OSHA)
Ethyl propenoate
Ethylacrylaat (Dutch)
Ethylakrylat (Czech)
Ethylester kyseliny akrylove (Czech)
Etil acrilato (Italian)
Etilacrilatului (Romanian)
NCI-C50384
RCRA waste number U113
2-Propenoic acid, ethyl ester
Acrylate d'ethyle (French)
Acrylsaeureaethylester (German)
Aethylacrylat (German)
Akrylanem etylu (Polish)
Carboset 511
Ethoxycarbonylethylene
Ethyl 2-propenoate
Ethyl acrylate
Ethyl acrylate (ACGIH:OSHA)
Ethyl propenoate
Ethylacrylaat (Dutch)
Ethylakrylat (Czech)
Ethylester kyseliny akrylove (Czech)
Etil acrilato (Italian)
Etilacrilatului (Romanian)
NCI-C50384
RCRA waste number U113
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /guinea pig | 1204 ppm/7H | JIHTAB 31,317,1949 | |
| eye /monkey | 1204 ppm/15H- intermittent | JIHTAB 31,317,1949 | |
| eye /rabbit | 45 mg | mild | UCDS** 12/14/1971 |
| eye /rabbit | 1204 ppm/7H | JIHTAB 31,317,1949 | |
| eye /rat | 1204 ppm/14H- intermittent | JIHTAB 31,317,1949 | |
| skin /rabbit | 500 mg open irritation test | mild | UCDS** 12/14/1971 |
| skin /rabbit | 10 mg/24H | mild | JIHTAB 31,311,1949 |
| skin /woman | 0.1%/48H | CODEDG 57,21,2007 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | lymphocyte/mouse | 20 mg/L | ENMUDM 8(Suppl 6),4,1986 |
| Cytogenetic Analysis | ovary/hamster | 299 mg/L | SCIEAS 236,933,1987 |
| Cytogenetic Analysis | lung/hamster | 9800 µg/L | GMCRDC 27,95,1981 |
| DNA Damage | other cell types/human | 10 µmol/L/24H (+enzymatic activation step) | MUREAV 760,23,2014 |
| DNA Damage | other cell types/human | 100 µmol/L/24H | MUTAEX 31,83,2016 |
| micronucleus test | lymphocyte/mouse | 12 mg/L/30H | MUREAV 789,7,2015 |
| micronucleus test | other cell types/human | 6 mg/L/24H | MUREAV 789,7,2015 |
| micronucleus test | intraperitoneal/mouse | 225 mg/kg | MUREAV 135,189,1984 |
| micronucleus test | ovary/hamster | 20 mg/L/24H (-enzymatic activation step) | MUREAV 742,11,2012 |
| micronucleus test | lymphocyte/human | 38 mg/L/24H (-enzymatic activation step) | MUREAV 742,11,2012 |
| micronucleus test | lung/hamster | 1 mg/L/24H (-enzymatic activation step) | MUREAV 742,11,2012 |
| micronucleus test | other cell types/human | 10 mg/L/24H (-enzymatic activation step) | MUREAV 742,11,2012 |
| micronucleus test | liver/human | 35 mg/L/24H (-enzymatic activation step) | MUREAV 742,11,2012 |
| mutation in mammalian somatic cells | lymphocyte/mouse | 20 mg/L | ENMUDM 8(Suppl 6),4,1986 |
| mutation in microorganisms | lymphocyte/mouse | 20 mg/L (+enzymatic activation step) | ENMUDM 8(Suppl 6),4,1986 |
| mutation in microorganisms | /Salmonella typhimurium | 100 µg/plate (-enzymatic activation step) | ENMUDM 5(Suppl 1),3,1983 |
| sister chromatid exchange | ovary/hamster | 150 mg/L | SCIEAS 236,933,1987 |
| specific locus test | other cell types/human | 100 µmol/L/24H | EMMUEG 54,737,2013 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 200 ppm/6H (6-20D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TOSCF2 48,240,1999 |
| inhalation/rat | 200 ppm (6-20D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other effects on female | TOSCF2 48,240,1999 |
| oral/rat | 8 gm/kg (0-19D pregnant) | Reproductive: Other effects on female | NTIS** OTS0557583 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| oral/mouse | lowest published toxic dose: 103 gm/kg/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | NTPTR* NTP-TR-259,1986 |
| oral/mouse | lowest published toxic dose: 51500 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | NTIS** PB87-204061/AS |
| oral/rat | lowest published toxic dose: 51500 mg/kg/2Y- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | NTPTR* NTP-TR-259,1986 |
| oral/rat | lowest published toxic dose: 51500 mg/kg/103W- intermittent | Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors | NTIS** PB87-204061/AS |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, skin | Inhibitor Concentration (20 percent kill): 40.0 mg/L/21H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,314,2013 |
| In Vitro/Human, skin | Inhibitor Concentration Low: 40.0 mg/L/4H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,314,2013 |
| inhalation/guinea pig | Lowest published lethal concentration: 1204 ppm/7H | Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Cough | JIHTAB 31,317,1949 |
| inhalation/human | lowest published toxic concentration: 50 ppm | Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Other changes | 34ZIAG -,75,1969 |
| inhalation/human | lowest published toxic dose: 5 ppm/4H | Eye: Other eye effects | TOLED5 196S,S3,2010 |
| inhalation/monkey | Lethal concentration: >75 ppm/6H | Olfaction: Deviated nasal septum Olfaction: Ulcerated nasal septum | TOXID9 36(1 Pt2),113,1997 |
| inhalation/mouse | lowest published toxic concentration: 200 ppm/6M | Lung, Thorax, or Respiration: Respiratory depression | TOLED5 9,137,1981 |
| inhalation/mouse | lethal concentration (50 percent kill): 16200 mg/m3 | GTPZAB 23(9),55,1979 | |
| inhalation/rabbit | Lowest published lethal concentration: 1204 ppm/7H | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Gastrointestinal: Hypermotility, diarrhea | JIHTAB 31,317,1949 |
| inhalation/rat | lowest published toxic concentration: 25 ppm/3H | Olfaction: Change in olfactory nerve Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 183,23,2002 |
| inhalation/rat | lowest published toxic concentration: 4.2 gm/m3/6H | Liver: Other changes Endocrine: Hyperglycemia Biochemical: Metabolism (intermediary): Other | TXCYAC 65,209,1990 |
| inhalation/rat | lethal concentration (50 percent kill): 1414 ppm/4H | Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | NTIS** OTS0520180 |
| inhalation/rat | lethal concentration (50 percent kill): 2180 ppm/4H | ENTOX* -,279,2005 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 599 mg/kg | JDREAF 51,526,1972 | |
| intraperitoneal/rat | lethal dose (50 percent kill): 450 mg/kg | AMPMAR 36,58,1975 | |
| oral/cat | Lethal dose: >800 µL/kg | Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Nausea or vomiting | NTIS** OTS0521003 |
| oral/mouse | lethal dose (50 percent kill): 1799 mg/kg | TOLED5 11,125,1982 | |
| oral/rabbit | lethal dose (50 percent kill): 370 mg/kg | Gastrointestinal: Alteration in gastric secretion | NTIS** OTS0521003 |
| oral/rat | lethal dose (50 percent kill): 800 mg/kg | BCTKAG 12,405,1979 | |
| skin/mouse | lethal dose (50 percent kill): 2997 mg/kg | NTIS** OTS0520999 | |
| skin/rabbit | lethal dose (50 percent kill): 500 µL/kg | Lung, Thorax, or Respiration: Acute pulmonary edema Liver: Other changes Skin: After systemic exposure: Dermatitis, other | NTIS** OTS0520180 |
| skin/rat | lethal dose (50 percent kill): 3049 mg/kg | ENTOX* -,279,2005 | |
| skin/rat | lowest published lethal dose: 1800 mg/kg | PJPPAA 32,223,1980 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/mouse | lowest published toxic concentration: 75 ppm/6H/26W- intermittent | Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain | APTOD9 19,A53,1980 |
| inhalation/mouse | lowest published toxic concentration: 75 ppm/6H/2Y- intermittent | Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain | DCTODJ 8,1,1985 |
| inhalation/mouse | lowest published toxic concentration: 75 ppm/6H/1Y- intermittent | Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0544830 |
| inhalation/mouse | lowest published toxic concentration: 300 ppm/6H/30D- intermittent | Olfaction: Deviated nasal septum Olfaction: Ulcerated nasal septum Olfaction: Other olfaction effects | NTIS** OTS0540690 |
| inhalation/rat | lowest published toxic concentration: 75 ppm/6H/2Y- intermittent | Olfaction: Other olfaction effects Nutritional and Gross Metabolic: Weight loss or decreased weight gain | DCTODJ 8,1,1985 |
| inhalation/rat | lowest published toxic concentration: 300 ppm/7H/30D- intermittent | Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JIHTAB 31(6),311,1949 |
| inhalation/rat | lowest published toxic concentration: 75 ppm/6H/26W- intermittent | Olfaction: Other olfaction effects | NTIS** OTS0520180 |
| oral/mouse | lowest published toxic dose: 2800 mg/kg/14D- intermittent | Gastrointestinal: Other changes | NTPTR* NTP-TR-259,1986 |
| oral/rat | lowest published toxic dose: 5600 mg/kg/28D- continuous | Gastrointestinal: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NTIS** OTS0533909 |
| oral/rat | lowest published toxic dose: 6500 mg/kg/13W- intermittent | Gastrointestinal: Other changes | NTIS** OTS0540988 |
| oral/rat | lowest published toxic dose: 183 gm/kg/2Y- continuous | Behavioral: Food intake (animal) Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 6,29,1964 |
| oral/rat | lowest published toxic dose: 11200 mg/kg/14D- intermittent | Gastrointestinal: Ulceration or bleeding from stomach | NTPTR* NTP-TR-259,1986 |
| oral/rat | lowest published toxic dose: 800 mg/kg/4D- intermittent | Gastrointestinal: Ulceration or bleeding from stomach Gastrointestinal: Other changes | TXAPA9 80,323,1985 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 15 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 39,81,1986 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Sufficient Evidence | IMEMDT 71,1447,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 39,81,1986 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 71,1447,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 2B | IMEMDT 71,1447,1999 |
| TOXICOLOGY REVIEW | EVHPAZ 11,141,1975 | |
| TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
| TOXICOLOGY REVIEW | MUREAV 567,227,2004 | |
| TOXICOLOGY REVIEW | EMMUEG 39,69,2002 | |
| TOXICOLOGY REVIEW | ENTOX* -,279,2005 | |
| TOXICOLOGY REVIEW | MUREAV 584,1,2005 | |
| TOXICOLOGY REVIEW | RTOPDW 53,6,2009 | |
| TOXICOLOGY REVIEW | MUREAV 723,101,2011 | |
| TOXICOLOGY REVIEW | MUREAV 653,99,2008 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | MUREAV 769,34,2014 | |
| TOXICOLOGY REVIEW | MUREAV 795,7,2016 | |
| TOXICOLOGY REVIEW | MUREAV 802,1,2016 | |
| TOXICOLOGY REVIEW | RTOPDW 54,247,2009 | |
| TOXICOLOGY REVIEW | RTOPDW 55,43,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 25 ppm (100 mg/m3) (skin) | DTLVS* 3,102,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | ceiling concentration 5 ppm (20 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (20 mg/m3);KZW 10 ppm (40 mg/m3), skin, sen, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (20 mg/m3), short term exposure limit 15 ppm (62 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 5 ppm (20 mg/m3), skin, carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (42 mg/m3), skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 5 ppm (20 mg/m3), Skin, FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 5 ppm (21 mg/m3), skin, sen, 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 10 mg/m3, short term exposure limit 10 mg/m3, Skin, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 5 ppm (20 mg/m3), skin, sen, NOV2011 | |
| Occupational Exposure Limit-JAPAN | 2B carc, MAY2012 | |
| Occupational Exposure Limit-KOREA | time-weighted average 5 ppm (20 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 5 ppm (20 mg/m3);short term exposure limit 25 ppm (100 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 5 ppm (20 mg/m3), sen, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 5 ppm (20 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 ppm (20 mg/m3); short term exposure limit 15 ppm (61 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | time-weighted average 20 mg/m3, short term exposure limit 80 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | time-weighted average 5 mg/m3, short term exposure limit 15 mg/m3, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 5 ppm (20 mg/m3);short term exposure limit 10 ppm (40 mg/m3), Skin, Sen, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 5 ppm (20 mg/m3), KZG-week 10 ppm (40 mg/m3), sen, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 20 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-THE PHILIPPINES | time-weighted average 25 ppm (100 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 25 ppm (100 mg/m3), Skin, JAN1993 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 5 ppm (21 mg/m3);short term exposure limit 15 ppm (62 mg/m3), OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 25 ppm (100 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 25 ppm (100 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 25 ppm (100 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 25 ppm (100 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL ACRYLATE-air | Carcinogen (4.0 ppm LOQ) | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 31490; Number of Industries 26; Total Number of Facilities 2898; Number of Occupations 42; Total Number of Employees Exposed 44604; Total Number of Female Employees Exposed 7205 | |
| National Occupational Hazard Survey 1974 | Hazard Code 31490; Number of Industries 42; Total Number of Facilities 3312; Number of Occupations 51; Total Number of Employees Exposed 40491 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat | |
| NIOSH Analytical Method, 1994: Esters I, 1450 | |
| On EPA IRIS database | |
| OSHA ANALYTICAL METHOD #92 |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health