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Acetyl chloride, chloro -

RTECS #: AO6475000

CAS #: 79-04-9


UPDATE: May 2009 MW: 112.94 MF: C2H2Cl2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Chloracetyl chloride
  2. Chlorid kyseliny chloroctove (Czech)
  3. Chloroacetic acid chloride
  4. Chloroacetic chloride
  1. Chloroacetyl chloride
  2. Chloroacetyl chloride (ACGIH)
  3. Chlorure de chloracetyle (French)
  4. Monochloroacetyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 1,300 ppm/2 hour N/R 85INA8 5,123(89),1986
inhalation
rat
lethal concentration (50 percent kill): 660 ppm/1 hour N/R NTIS** OTS0555574
intravenous
mouse
lethal dose (50 percent kill): 32 mg/kg N/R CSLNX* NX#04538
oral
mouse
lethal dose (50 percent kill): 220 mg/kg N/R GISAAA 54(2),90,1989
oral
rat
lethal dose (50 percent kill): 208 mg/kg N/R 85INA8 5,123(89),1986
skin
rat
lethal dose (50 percent kill): 662 mg/kg Skin: After topical application: Corrosive GISAAA 54(2),90,1989
skin
rabbit
lowest published lethal dose: 316 mg/kg N/R 85INA8 5,123(89),1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
hamster
lowest published toxic concentration: 5 ppm/6 hour/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0536493
inhalation
mouse
lowest published toxic concentration: 5 ppm/6 hour/4 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0536493
inhalation
rat
lowest published toxic concentration: 1 ppm/6 hour/4 week- intermittent Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0536493


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm;short term exposure limit 0.15 ppm (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 ppm (0.23 mg/m3), short term exposure limit 0.15 ppm (0.69 mg/m3),JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.23 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.15 ppm (0.7 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.05 ppm (0.2 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 0.05 ppm (0.2 mg/m3), FEB2006
Occupational Exposure Limit - KOREA time-weighted average 0.05 ppm (0.2 mg/m3), 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 ppm (0.23 mg/m3);
short term exposure limit 0.15 ppm (0.69 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.05 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.24 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 ppm;
short term exposure limit 0.15 ppm (skin)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 ppm;
short term exposure limit 0.15 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROACETYL CHLORIDE-air 10 hour time-weighted average 0.05 ppm NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1131;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 1;
Total Number of Employees Exposed 66
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1131;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 5;
Total Number of Employees Exposed 4,354;
Total Number of Female Employees Exposed 729


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

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