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Molecular Identification of Streptomycin Monoresistant Mycobacterium tuberculosis Related to Multidrug-Resistant W Strain

Pablo Bifani,*† Barun Mathema,* Martha Campo,* Soraya Moghazeh,* Beth Nivin,‡ Elena Shashkina,* Jeffrey Driscoll,§ Sonal S. Munsiff,‡ Richard Frothingham,¶ and Barry N. Kreiswirth*
*Public Health Research Institute Tuberculosis Center, New York, NY, USA; †New York University School of Medicine, New York, New York, USA; ‡New York City Department of Health, New York, New York, USA; §New York State Department of Health, Albany, New York, USA; ¶Durham Veterans Affairs Medical Center, Durham, North Carolina


Figure 4. Schematic diagram on a plausible evolutionary pathway of the W14 Mycobacterium tuberculosis family, compared with the New York City W-MDR (4). All members of the W14 family lineage have single mutation on codon 43 of the rpsL target gene associated with high levels of streptomycin resistance (STRR). Note that isoniazid-resistant (INHR) W23 and W14 branches have a distinct katG mutation. The W23 katG substitution on codon 315 is found on the same codon as in the W-MDR index strain but involves a different nucleotide; the W14 katG insertion on codon 283 has not been previously reported. ETH = ethionamide resistant; PZA = pyrazinamide resistant; EMB = ethambutol resistant; R = resistant.

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Figure 4. Schematic diagram on a plausible evolutionary pathway of the W14 Mycobacterium tuberculosis group, compared with the New York City W-MDR (4). All members of the W14 group lineage have single mutation on codon 43 of the rpsL target gene associated with high levels of streptomycin resistance (STRR). Note that isoniazid-resistant (INHR) W23 and W14 branches have a distinct katG mutation. The W23 katG substitution on codon 315 is found on the same codon as in the W-MDR index strain but involves a different nucleotide; the W14 katG insertion on codon 283 has not been previously reported. ETH = ethionamide resistant; PZA = pyrazinamide resistant; EMB = ethambutol resistant; R = resistant.
 


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This page last reviewed December 08, 2001

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
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