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West Nile Virus

West Nile Virus Infection in the Golden Hamster (Mesocricetus auratus): A Model for West Nile Encephalitis

Shu-Yuan Xiao, Hilda Guzman, Hui Zhang, Amelia P.A. Travassos da Rosa, and Robert B. Tesh
University of Texas Medical Branch, Galveston, Texas, USA

Figure 3. Histologic changes in brains of West Nile virus-infected hamsters. a. Cerebral cortex, with many degenerating neurons, day 6 postinfection. b. Hippocampus, showing large neurons undergoing degeneration, day 6. c. Cerebellar cortex, with frequent Purkinje call degeneration (shrunken cells, arrowheads) and loss, day 8. d. A microglial nodule near blood vessel in basal ganglia, day 9. e. Mild perivascular inflammation (upper left field), neurons with nuclear condensation (arrowhead) and cytoplasmic eosinophilia, in brain stem, day 9. f. Spongiform change in the brain stem, day 10. Magnification 100x.

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Figure 3. Histologic changes in brains of West Nile virus-infected hamsters. A. Cerebral cortex, with many degenerating neurons, day 6 postinfection. B. Hippocampus, showing large neurons undergoing degeneration, day 6. C. Cerebellar cortex, with frequent Purkinje call degeneration (shrunken cells, arrowheads) and loss, day 8. D. A microglial nodule near blood vessel in basal ganglia, day 9. E. Mild perivascular inflammation (upper left field), neurons with nuclear condensation (arrowhead) and cytoplasmic eosinophilia, in brain stem, day 9. F. Spongiform change in the brain stem, day 10. Magnification 100x.
 


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This page last reviewed December 08, 2001

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
Centers for Disease Control and Prevention