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West Nile Virus

Rapid Determination of HLA B*07 Ligands from the West Nile Virus NY99 Genome

Anne S. De Groot,*† Caitlin Saint-Aubin,* Andrew Bosma,* Hakima Sbai,* James Rayner,† and William Martin†
*Brown University, Providence, Rhode Island, USA; and †EpiVax, Inc., Providence, Rhode Island, USA

Figure 2. EpiMatrix HLA B*07 score distributions for a random set of 10,000 peptides (dark blue), a set of 20 West Nile (WN) virus peptides selected for screening (magenta), and a set of known HLA B*07 ligands (light blue) are compared. The natural log of estimated binding potential (EBP) for all three sets (random, known binders, and WN virus selections) fell within the range -5 to 5. Scores for the set of WN virus peptides selected for this study are higher than those of most random peptides and are within the same range as scores of published HLA B*07 binders.

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Figure 2. EpiMatrix HLA B*07 score distributions for a random set of 10,000 peptides (dark blue), a set of 20 West Nile (WN) virus peptides selected for screening (magenta), and a set of known HLA B*07 ligands (light blue) are compared. The natural log of estimated binding potential (EBP) for all three sets (random, known binders, and WN virus selections) fell within the range -5 to 5. Scores for the set of WN virus peptides selected for this study are higher than those of most random peptides and are within the same range as scores of published HLA B*07 binders.
 


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This page last reviewed December 08, 2001

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
Centers for Disease Control and Prevention