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Volume 12, Number 2, February 2006

Antimicrobial Drug Resistance, Regulation, and Research

Joshua P. Metlay,*† John H. Powers,‡ Michael N. Dudley,§ Keryn Christiansen,¶ and Roger G. Finch#** on behalf of the Second Colloquium of the International Forum on Antibiotic Resistance
*VA Medical Center, Philadelphia, Pennsylvania, USA; †University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA; ‡US Food and Drug Administration, Rockville, Maryland, USA; §Diversa Corporation, San Diego, California, USA; ¶Royal Perth Hospital, Perth, Western Australia, Australia; #Nottingham City Hospital, Nottingham, United Kingdom; and **University of Nottingham, Nottingham, United Kingdom

 
 
Figure 4.
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Figure 4. Relationship between the dominant pharmacokinetic/pharmacodynamic (PK/PD) index, efficacy, and resistance emergence in vitro (both quantified by the number of bacterial colony-forming units). The PK/PD index is related to efficacy in a sigmoid curve and the resistance emergence by an inverted U-shaped curve (21).

 

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This page last reviewed January 20, 2006

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