Volume 10, Number 3, March 2004

Monkeypox Transmission and Pathogenesis in Prairie Dogs

Jeannette Guarner,* Bill J. Johnson,† Christopher D. Paddock,* Wun-Ju Shieh,* Cynthia S. Goldsmith,* Mary G. Reynolds,* Inger K. Damon,* Russell L. Regnery,* Sherif R. Zaki,* and the Veterinary Monkeypox Virus Working Group
*Centers for Disease Control and Prevention, Atlanta, Georgia, USA; and †Oklahoma Animal Disease Diagnostic Laboratory, Oklahoma State University, Stillwater, Oklahoma, USA

Figure 3. Lung of prairie dog infected with monkeypox virus, showing abundant intraalveolar mixed inflammatory infiltrate and necrosis (A: hematoxylin and eosin stain, 50X original magnification). Orthopox viral antigens are abundant in the cytoplasm of the bronchiolar epithelium (D: immunohistochemical assay anti–variola virus antibody, 100X original magnification). Macrophages, fibroblasts, and alveolar epithelial cells, as well as necrotic debris demonstrate orthopox viral antigens in pneumonic areas of the lung (C: immunohistochemical stain anti–variola virus antibody, 100X original magnification). Accumulation of intracellular mature virions (arrow) in bronchial epithelial cell (arrowhead pointing to cilia) (B: transmission electron microscopy, 2,400X original magnification).

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This page last reviewed January 30, 2004

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
Centers for Disease Control and Prevention