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Current
Research
The WHOCC-Plague
is currently involved in a wide variety of collaborative research projects
involving laboratories and plague prevention programs in the United
States and other countries.
These collaborative
projects include:
- An ISTC/BTEP-funded
project with the Kazakh Institute for Research on Plague Control to
perform a comparative investigation of Kazakh and United States plague
foci and perform molecular analyses of representative plague strains
from both countries.
- A Global EID-funded
project on rat-associated plague in Yunnan Province, People's Republic
of China. A major emphasis of this project is to perform molecular
analyses on Yunnan plague strains, including those bearing a cryptic
6 kb plasmid.
- Geographic
Information System (GIS) and remote sensing studies designed to better
characterize and identify areas at greatest risk for human plague
in the American Southwest.
- Mathematical
modeling studies designed to investigate the role of climatic factors
in the changing frequency of human plague cases in the American Southwest.
- Development
of multiplex PCR assays for detecting multiple flea-borne pathogens
(Yersinia pestis, Rickettsia spp., and Bartonella
spp.);
- Pulsed Field
Gel Electrophoresis studies of plague strains isolated during a plague
outbreak in New Mexico.
- Longitudinal
study of plague ecology in a plague-endemic region of New Mexico.
- Analysis of
the effects of quorum sensing on Yersinia pestis pathogenicity.
- Development
of rapid diagnostics for use under field conditions.
Publications resulting
from collaborative research activities of the WHOCC-Plague (1990-2001)
are listed in the Publications section of
this website.
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