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Division of Vector-Borne Infectious Diseases Dengue: Clinical Manifestations and Epidemiology

 
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Heterologous Antibodies Form Infectious Complexes

Image: Heterologous Antibodies Form Infectious Complexes
 
In this depiction of the second step in antibody-dependent enhancement, dengue type B represents the new serotype. The anti-A antibodies produced in response to the original infection can form complexes with the new serotype, as we see here. However, the new virus serotype is not neutralized by these heterologous antibodies. The virus retains its capacity to become active and replicate.

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This page last reviewed February 13, 2002

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