Volume 9, Number 4, April 2003

Human Neurobrucellosis with Intracerebral Granuloma Caused by a Marine Mammal Brucella spp.

Annette H. Sohn,* Will S. Probert,† Carol A. Glaser,*† Nalin Gupta,* Andrew W. Bollen,* Jane D. Wong,† Elizabeth M. Grace,* and William C. McDonald*
*University of California, San Francisco, San Francisco, California, USA; and †California Department of Health Services, Richmond, California, USA

Figure 1. Hematoxylin and eosin–stained sections from patient 1 (panels A, B) and patient 2 (panels C, D). Note the predominantly lymphohistocytic infiltrate forming large granulomas (A, original magnification 100x); well-formed giant cells (B, arrow, original magnification 200x); lymphohistiocytic infiltrates distorting brain parenchyma and forming vague granulomas (C, original magnification 40x); and the dense astrogliosis at the interface between granulomatous inflammation and surrounding brain parenchyma (D, asterisk, original magnification 100x).

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This page last reviewed March 18, 2003

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
Centers for Disease Control and Prevention