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Past Issue

Vol. 8, No. 2
February 2002

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Research

Surveillance for Unexplained Deaths and Critical Illnesses Due to Possibly Infectious Causes, United States, 1995-1998

Appendix 1: Case Definition, Surveillance for Unexplained Deaths and Critical Illnesses Due to Possibly Infectious Causes, United States, 1995-1998

Previously Healthy

Patients are considered previously healthy who had no known preexisting chronic medical condition before the onset of the illness resulting in hospitalization or death, including malignancy; HIV infection; chronic cardiac; pulmonary, renal, hepatic, or rheumatologic disease; or diabetes mellitus. These patients have no history of immunosuppressive therapy, trauma thought to be related to illness, evidence of toxic ingestion or exposure, or nosocomial infection.

Reasons for Exclusion

  • A history of a malignancy other than nonmelanoma skin cancer
  • HIV infection identified during hospitalization, previously or after discharge
  • History of physician-confirmed myocardial infarction, angina with known coronary artery disease, or congestive heart failure
  • Any history of hospital admission for asthma or other pulmonary diseases except for uncomplicated pneumonia
  • History of dialysis or chronically elevated blood urea nitrogen and creatinine
  • Biopsy-proven liver disease of any kind or chronic coagulopathy or chronic Hepatitis B or C virus infection as a result of hepatic insufficiency
  • Physician-confirmed rheumatologic conditions requiring chronic or intermittent medical therapy with oral steroids or other immunosuppressive drugs
  • Any known physician-confirmed diabetes mellitus previously or during hospitalization
  • Development of hallmarks of infection >48 hours after hospital admission
  • Any mention of a history of excessive alcohol use, alcohol abuse, or alcoholism is a reason for exclusion.(e.g., delirium tremens, withdrawal seizures, alcoholic neuropathy, persistent liver function test abnormalities, gastrointestinal bleeding, coagulopathy, or hypoalbuminemia).
  • Any mention of injecting drug use
  • Any history of neurologic disease, including seizures,
  • Obesity, defined as body mass index 30 or "obese" noted in medical chart
  • Physician-confirmed diagnosis of anorexia

Not Reasons for Exclusion

  • Hypertension or a history of hypertension
  • Any history of inhaler use
  • Pyelonephritis or nephrolithiasis or a history of either of these conditions in the absence of a chronically elevated blood urea nitrogen and creatinine
  • History of hepatitis
  • Pregnancy
      

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This page last reviewed December 29, 2001

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
Centers for Disease Control and Prevention