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West Nile Virus

Rapid Determination of HLA B*07 Ligands from the West Nile Virus NY99 Genome

Anne S. De Groot,*† Caitlin Saint-Aubin,* Andrew Bosma,* Hakima Sbai,* James Rayner,† and William Martin†
*Brown University, Providence, Rhode Island, USA; and †EpiVax, Inc., Providence, Rhode Island, USA

Figure 1. Distribution of scores for the complete set of 3,424 peptides obtained by parsing the West Nile (WN) virus genome into 10 amino-acid long peptides, each overlapping by 9 amino acids, as scored on the EpiMatrix motif for HLA B*07. Peptides with estimated binding potential (EBP) scores >7 and <50 with the HLA B*07 motif are highly likely to bind to HLA B*07 in T2 B7 assays and to stimulate T cells. WN virus peptides with EBP scores between 20 and 50 were considered for study.

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Figure 1. Distribution of scores for the complete set of 3,424 peptides obtained by parsing the West Nile (WN) virus genome into 10 amino-acid long peptides, each overlapping by 9 amino acids, as scored on the EpiMatrix motif for HLA B*07. Peptides with estimated binding potential (EBP) scores >7 and <50 with the HLA B*07 motif are highly likely to bind to HLA B*07 in T2 B7 assays and to stimulate T cells. WN virus peptides with EBP scores between 20 and 50 were considered for study.
 


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This page last reviewed December 08, 2001

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
Centers for Disease Control and Prevention