Volume 11, Number 7, July 2005

Influenza A H5N1 Replication Sites in Humans

Mongkol Uiprasertkul,* Pilaipan Puthavathana,* Kantima Sangsiriwut,* Phisanu Pooruk,* Kanittar Srisook,* Malik Peiris,† John M. Nicholls,† Kulkanya Chokephaibulkit,* Nirun Vanprapar,* and Prasert Auewarakul*
*Mahidol University, Bangkok, Thailand; and †University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China

Figure 3. Immunohistochemical analysis showing influenza A antigen-specific staining in nuclei of cells lining the alveoli (A). To identify the cell type, slides from consecutive sections were stained with anti–influenza A antibody (B) and double-stained with anti–influenza A and antisurfactant antibodies (C). The sections were mapped, and the same area in each section was examined. Viral antigen–positive cells were stained both intranuclearly with anti-influenza antibody and intracytoplasmically with antisurfactant antibody, indicating that the viral antigen–positive cells were type II pneumocytes. Viral antigen–positive cell are marked by circles (magnification ×400).

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This page last reviewed June 8, 2005

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
Centers for Disease Control and Prevention