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Figure 2. Photomicrographs of pathologic changes in tissues of
prairie dogs infected with monkeypox virus. A) Abdominal adipose tissue
from an intraperitoneally infected animal showing focal vasculitis (arrowheads),
necrosis, and proliferation of fibroblasts. B) Mild hepatitis, characterized
by focal inflammatory cell infiltration in the lobules and hepatocytes
containing cytoplasmic inclusion bodies (arrowheads). C) Severe necrosis
of the thymus from an animal infected intranasally. The necrotic areas
contain many swollen macrophages with cytoplasm full of intensively eosinophilic
material (viral proteins). D) Lung from the same animal, showing inflammation
with swollen cells (arrowheads), alveolar edema, and necrosis of the pleura.
The latter is infiltrated by many inclusion-filled macrophages and proliferating
fibroblasts (the thick layer between the 2 arrows). Magnification: A,
10× objective; B, 40× objective; C, 10× objective; D,
20× objective. Hematoxylin and eosin stain.
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