Volume 11, Number 3, March 2005

Rapid Identification of Emerging Pathogens: Coronavirus

Rangarajan Sampath,* Steven A. Hofstadler,* Lawrence B. Blyn,* Mark W. Eshoo,* Thomas A. Hall,* Christian Massire,* Harold M. Levene,* James C. Hannis,* Patina M. Harrell,* Benjamin Neuman,† Michael J. Buchmeier,† Yun Jiang,* Raymond Ranken,* Jared J. Drader,* Vivek Samant,* Richard H. Griffey,* John A. McNeil,* Stanley T. Crooke,* and David J. Ecker*
*Ibis Therapeutics, Carlsbad, California, USA; and †The Scripps Research Institute, La Jolla, California, USA

Figure 2. Detection of 3 human coronaviruses (CoV) in a mixture. The deconvoluted (neutral mass) mass spectra obtained for the RNA-dependent RNA polymerase primer for the 3 human CoV, HCoV-229E, HCoV-OC43, and severe acute respiratory syndrome–associated CoV, which were tested individually and in a mixture, are shown. Forward and reverse amplicons are shown with the measured monoisotopic masses for each strand. Colors of the monoisotopic masses for the mixed spectra correspond to the individual viral species.

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This page last reviewed February 8, 2005

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
Centers for Disease Control and Prevention