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Volume 11, Number 2, February 2005 Human Disease from Influenza A (H5N1), Thailand, 2004Tawee Chotpitayasunondh,* Kumnuan Ungchusak,† Wanna Hanshaoworakul,†
Supamit Chunsuthiwat,† Pathom Sawanpanyalert,† Rungruen Kijphati,† Sorasak
Lochindarat,* Panida Srisan,* Pongsan Suwan,† Yutthasak Osotthanakorn,†
Tanakorn Anantasetagoon,† Supornchai Kanjanawasri,† Sureeporn Tanupattarachai,†
Jiranun Weerakul,† Ruangsri Chaiwirattana,† Monthira Maneerattanaporn,†
Rapol Poolsavatkitikool,† Kulkunya Chokephaibulkit,‡ Anucha Apisarnthanarak,§
and Scott F. Dowell¶ |
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Figure 5. Pathologic findings from a patient (number 6) with confirmed influenza A (H5N1) infection. All slides are stained with hematoxylin and eosin, shown at 40x objective. Panel A shows hyaline membrane formation lining the alveolar spaces of the lung and vascular congestion with a few infiltrating lymphocytes in the interstitial areas. Reactive fibroblasts are also present. Panel B is an area of lung with proliferating reactive fibroblasts within the interstitial areas. Few lymphocytes are seen, and no viral intranuclear inclusions are visible. Panel C shows fibrinous exudates filling the alveolar spaces, with organizing formation and few hyaline membranes. The surrounding alveolar spaces contain hemorrhage. Panel D is from a section of spleen, showing numerous atypical lymphoid cells scattered around the white pulp. No viral intranuclear inclusions are seen. |
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