Volume 10, Number 3, March 2004

Monkeypox Transmission and Pathogenesis in Prairie Dogs

Jeannette Guarner,* Bill J. Johnson,† Christopher D. Paddock,* Wun-Ju Shieh,* Cynthia S. Goldsmith,* Mary G. Reynolds,* Inger K. Damon,* Russell L. Regnery,* Sherif R. Zaki,* and the Veterinary Monkeypox Virus Working Group
*Centers for Disease Control and Prevention, Atlanta, Georgia, USA; and †Oklahoma Animal Disease Diagnostic Laboratory, Oklahoma State University, Stillwater, Oklahoma, USA

Figure 2. Ulcer on tongue of a prairie dog infected with monkeypox virus (A: hematoxylin and eosin stain, 12.5X original magnification). Orthopox viral antigens are abundant in the squamous epithelium, with lesser amounts in the ulcer bed (B: immunohistochemical stain using the anti-variola virus antibody, 12.5X original magnification). Tongue epithelial cell adjacent to epidermal basement membrane (small arrows) with Guarnieri-like inclusion (large arrow) (C: transmission electron microscopy, 2,400X original magnification). Higher magnification of the Guarnieri-like inclusion shows intracellular immature (arrowhead) and mature (arrows) orthopox virions. The mature virions consist of a dense core surrounded by several laminated zones and enclosed within an outer membrane (D: transmission electron microscopy, 17,000X original magnification).

EID Home | Top of Page | Ahead-of-Print | Past Issues | Suggested Citation | EID Search | Contact Us | Accessibility | Privacy Policy Notice | CDC Home | CDC Search | Health Topics A-Z

This page last reviewed February 19, 2004

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
Centers for Disease Control and Prevention