Volume 10, Number 2, February 2004

Interferon-ß1a and SARS Coronavirus Replication

Lisa E. Hensley,* Elizabeth A. Fritz,* Peter B. Jahrling,* Christopher L. Karp,† John W. Huggins,* and Thomas W. Geisbert*
*U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA; and Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA

Figure 2. IFN-ß 1a inhibition of SARS-CoV cytopathicity in Vero E6 cells. Vero E6 cells were infected with the Tor2 isolate of SARS-CoV and incubated for 72 h in the absence (left panel) or presence (right panel) of 500,000 IU of recombinant human IFN-ß 1a. Cell rounding and detachment were prominent in the absence of IFN-ß 1a. Minimal cell rounding or death was noted in the intact monolayer at 72 h postinoculation in the presence of IFN-ß 1a (note: IFN-ß 1a administered 1 h postinoculation).

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This page last reviewed January 22, 2004

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
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