Volume 10, Number 12, December 2004

Novel Avian Influenza H7N3 Strain Outbreak, British Columbia

Martin Hirst,* Caroline R. Astell,* Malachi Griffith,* Shaun M. Coughlin,* Michelle Moksa,* Thomas Zeng,* Duane E. Smailus,* Robert A. Holt,* Steven Jones,* Marco A. Marra,* Martin Petric,† Mel Krajden,† David Lawrence,† Annie Mak,† Ron Chow,† Danuta M. Skowronski,† S. Aleina Tweed,† SweeHan Goh,† Robert C. Brunham,† John Robinson,‡ Victoria Bowes,‡Ken Sojonky,‡ Sean K. Byrne,‡ Yan Li,§ Darwyn Kobasa,§ Tim Booth,§ and Mark Paetzel¶
*British Columbia Cancer Agency (BCCA) Genome Sciences Centre, Vancouver, British Columbia, Canada; †British Columbia Centre for Disease Control and University of British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada; ‡Ministry of Agriculture, Abbotsford, British Columbia, Canada; §Canadian Centre for Human and Animal Health, Winnipeg, Manitoba, Canada; and ¶Simon Fraser University, Burnaby, British Columbia, Canada

Figure 2. A homology model of the human A/Canada/504/04 (Hu504) hemagglutinin precursor (HA0) trimer based on the crystal structure of the human strain CV-1 HA0 (PDB: 1HA0) sequence identity 49.9%. A) Molecule A is shown as a green ribbon diagram; molecules B and C are shown in blue and yellow molecular surfaces, respectively. The 8–amino-acid (aa) sequence 335-342 (NPKQAYQK) is shown in red. B) A close up of this region located between molecules A (in green ribbon) and molecule C (in yellow surface). This 8-aa sequence forms a loop, which bumps into the adjoining molecule before energy minimization (gray). Shown in red is the loop after energy minimization, which results in the cleavage site's being pushed out slightly. Shown in blue is the corresponding region for the template structure (PDB code 1HA0). The side chains for arginine 343 and arginine 346 (–1 residue) are shown in stick form. (Since the preparation of this manuscript, the structure of an H7 HA protein has been reported [12]).

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This page last reviewed November 19, 2004

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