Volume 10, Number 11, November 2004

Topographic Changes in SARS Coronavirus–infected Cells at Late Stages of Infection

M.L. Ng,* J.W.M. Lee,* M.L.N. Leong,* A.-E. Ling,† H.-C. Tan‡ and E.E. Ooi‡
*National University of Singapore, Singapore; †Singapore General Hospital, Singapore; and ‡National Environment Agency, Singapore

Figure 4. Atomic force microscopy of Vero cells infected with severe acute respiratory syndrome–associated coronavirus at 15 h after infection. A) At much higher resolution imaging of the edge of a cell, a virus particle (thick arrow) in the process of extruding from the cell plasma membrane (PM) after fusion of the transport vesicle with the cell membrane. PM shows some loss of integrity (thin arrows) during this exit process. B) A three-dimensional reconstruction of the extruding virus particle from panel B. Arrow indicates the thickened cell edge. C) Arrow indicates the knoblike structures on the virus particles.

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This page last reviewed October 14, 2004

Emerging Infectious Diseases Journal
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