Table of Contents

Locator Record

Title: Transferrin Receptor (TFR_D )
Contact Number: 1-866-441-NCHS
Years of Content: 2005 - 2006
First Published: April, 2008
Revised: NA
Access Constraints: None
Use Constraints: None
Geographic Coverage: National
Subject:Transferrin Receptor
Record Source: NHANES 2005 - 2006
Survey Methodology: NHANES 2005 - 2006 is a stratified multistage probability sample of the civilian non-institutionalized population of the U.S.
Medium: NHANES Web site; SAS transport files

Component Description

The objectives of this component are:

  1. to provide data for monitoring secular trends in measures of nutritional status in the U.S. population;
  2. to evaluate the effect of people's habits and behaviors such as physical activity and the use of alcohol, tobacco, and dietary supplements on people's nutritional status; and
  3. to evaluate the effect of changes in nutrition and public health policies including welfare reform legislation, food fortification policy, and child nutrition programs on the nutritional status of the U.S. population.

These data will be used to estimate deficiencies and toxicities of specific nutrients in the population and subgroups, to provide population reference data, and to estimate the contribution of diet, supplements, and other factors to serum levels of nutrients. Data will be used for research to further define nutrient requirements as well as optimal levels for disease prevention and health promotion.

Eligible Sample

Participants aged 1-5 years both genders and females 12 to 49 years who do not meet any of the exclusion criteria are eligible.

Description of Laboratory Methodology

Transferrin Receptor

The method for measurement of soluble transferrin receptor (sTfR) is immuno-turbidimetry using Roche kits on the Hitachi 912 clinical analyzer. Latex bound anti-sTfR antibodies react with the antigen in the sample to form an antigen/antibody complex. Following agglutination, this is measured turbidimetrically.

Data Processing and Editing

Serum specimens were processed, stored, and shipped to the Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention for analysis.

Detailed specimen collection and processing instructions are discussed in the NHANES Laboratory/Medical Technologists Procedures Manual (LPM). Vials are stored under appropriate frozen (–20°C) conditions until they are shipped to National Center for Environmental Health for testing.

Detailed instructions on specimen collection and processing can be found at NHANES web page.

Laboratory Quality Assurance and Monitoring

The NHANES quality control and quality assurance protocols (QA/QC) meet the 1988 Clinical Laboratory Improvement Act mandates. Detailed quality control and quality assurance instructions are discussed in the NHANES Laboratory/Medical Technologists Procedures Manual (LPM). Read the LABDOC file for detailed QA/QC protocols.

A detailed description of the quality assurance and quality control procedures can be found at NHANES web site.

Analytic Notes

General Analytical Note:

The analysis of NHANES 2005–2006 laboratory data must be conducted with the key survey design and basic demographic variables. The NHANES 2005–2006 Household Questionnaire Data Files contain demographic data, health indicators, and other related information collected during household interviews. The Household Questionnaire Data Files also contain all survey design variables and sample weights required to analyze these data. The Phlebotomy Examination file includes auxiliary information on duration of fasting, the time of day of the venipuncture, and the conditions precluding venipuncture. The Household Questionnaire and Phlebotomy Exam files may be linked to the laboratory data file using the unique survey participant identifier SEQN.

Please refer to the Analytic Guidelines for further details on the use of sample weights and other analytic issues.

References

Codebook and Frequencies

SEQN - Respondent sequence number

Variable Name:
SEQN
SAS Label:
Respondent sequence number
English Text:
Respondent sequence number.
Target:
Both males and females 1 YEARS - 5 YEARS
Target:
Females only 12 YEARS - 49 YEARS

LBXTFR - Transferrin Receptor (mg/L)

Variable Name:
LBXTFR
SAS Label:
Transferrin Receptor (mg/L)
English Text:
Transferrin Receptor (mg/L)
Target:
Both males and females 1 YEARS - 5 YEARS
Target:
Females only 12 YEARS - 49 YEARS
Code or Value Value Description Count Cumulative Skip to Item
1.1 to 28.6 Range of Values 3025 3025
. Missing 885 3910