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HIV Prevention in the United States:

Expanding the Impact

Expanding the Impact
To Date
in HIV
of HIV

In the United States, it is estimated that prevention efforts have already averted more than 350,000 HIV infections.1 Since the height of the epidemic in the mid-1980s, the annual number of new HIV infections in the United States has been reduced by more than two-thirds, and recent scientific breakthroughs have equipped us with an unprecedented number of effective tools to prevent infection.2-6

CDC believes that maximizing the impact of these tools within the framework of a new approach called High-Impact Prevention offers more hope than ever before for reversing the U.S. HIV epidemic. Through High-Impact Prevention, CDC is working to advance the goals of the first National HIV/AIDS Strategy (NHAS) and to help ensure that HIV prevention efforts have the greatest possible impact.

Future of HIV Prevention (print version)

Key References:

1Farnham PG, Holtgrave DR, Sansom SL et al. Medical costs averted by HIV prevention efforts in the United States, 1991-2006. J Aquir Immune Defic Syndr 2010;54:565-67.
2CDC. Estimated HIV incidence among adults and adolescents in the United States, 2007–2010. HIV Surveillance Supplemental Report 2012;17(No. 4). Available at: Published December 2012.
3Grant RM, Lama JR, Anderson PL, et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. iPrEx Study Group. N Engl J Med 2010;363(27):2587-99.
4Cohen MS, Chen YQ, McCauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. The HPTN 052 Study Team. N Engl J Med 2011. DOI:10.1056/nejmoa1105243.
5Thigpen MC, Kebaabetswe PM, Smith DK, et al. Daily oral antiretroviral use for the prevention of HIV infection in heterosexually active young adults in Botswana: results from the TDF2 study. 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention. July 17-20, 2011. Rome. Abstract WELBC01.
6Baeten J. Antiretroviral pre-exposure prophylaxis for HIV-1 prevention among heterosexual African men and women: the Partners PrEP study. 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention. July 17-20, 2011. Rome. Abstract MOAX0106.
7The White House Office of National AIDS Policy. National HIV/AIDS Strategy for the United States. July 2010. Available at: (Accessed June 25, 2012)
8CDC. Results of the expanded HIV testing initiative – 25 jurisdictions, United States, 2007-2010. MMWR 2011;60(24):805-10.
9Hutchinson AB, Farnham PG, Duffy N, et al. Return on public health investment: CDC’s Expanded HIV Testing Initiative. J Acquir Immune Defic Syndr 2012;59(3):281-86.
10Lasry A, Sansom S, Hicks K, et al. Allocating HIV prevention funds in the United States: recommendations from an optimization model. PLoSOne 2012;7(6):e37505. DOI: 10.1371/journal.pone.0037545.
11Hall HI, Green TA, Wolitski RJ et al. Estimated future HIV prevalence, incidence, and potential infections averted in the United States: a multiple scenario analysis. J Acquir Immune Defic Syndr 2010;55(2):271-76.

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