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Free-Living & Intestinal Amebas Laboratory (“Ameba Lab”)

Photo: Specimen analysis for free-living amebas

Specimen analysis for free-living amebas

Photo: Balamuthia mandrillaris trophozoite and cyst

Balamuthia mandrillaris trophozoite and cyst

Photo: Naegleria fowleri in a brain section

Naegleria fowleri in a brain section

Mission: Developing and applying diagnostic methods and drug therapies for opportunistic and pathogenic free-living and intestinal amebas to prevent future infections.

(A) For free-living amebas our laboratory:

  • Diagnoses amebic infections, including pathogenic free-living Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia using real-time PCR and immunofluorescence techniques
  • Detects and identifies free-living amebas in environmental samples
  • Develops and assesses drug therapies for free-living amebic infections
  • Investigates genome sequences of free-living amebas
  • Develops serologic methods for diagnosis of free-living amebic infections
  • Develops simple ELISA-based method for diagnosis of free-living amebas
  • Investigates stage-specific proteome of free-living amebas

(B) For intestinal amebas our laboratory:

  • Diagnoses amebic infections, including Entamoeba histolytica and Entamoeba dispar using real-time PCR
  • Detects E. histolytica specific antibodies in serum samples using  ELISA method
  • Detects genotypes of infecting ameba using tRNA gene-linked typing method
  • Develops novel genotyping and SNP-based methods for differentiation of clinical strains of E. histolytica
  • Tests and assesses new drug therapies for intestinal amebic infections
  • Investigates genomic differences that may account for differential outcome of infections using next generation sequencing techniques

Free-Living & Intestinal Amebas Laboratory Highlights

 
 
Contact Us:
  • Centers for Disease Control and Prevention
    1600 Clifton Rd
    Atlanta, GA 30333
  • 800-CDC-INFO
    (800-232-4636)
    TTY: (888) 232-6348
  • Contact CDC–INFO
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Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC-INFO